The Role of PPAR-γ in Allergic Disease

Research output: Contribution to journalReviewResearchpeer-review

PURPOSE OF REVIEW: The incidence of allergic diseases such as asthma, rhinitis and atopic dermatitis has risen at an alarming rate over the last century. Thus, there is a clear need to understand the critical factors that drive such pathologic immune responses. Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a nuclear receptor that has emerged as an important regulator of multiple cell types involved in the inflammatory response to allergens; from airway epithelial cells to T Helper (TH) cells.

RECENT FINDINGS: Initial studies suggested that agonists of PPAR-γ could be employed to temper allergic inflammation, suppressing pro-inflammatory gene expression programs in epithelial cells. Several lines of work now suggest that PPAR-γ plays an essential in promoting 'type 2' immune responses that are typically associated with allergic disease. PPAR-γ has been found to promote the functions of TH2 cells, type 2 innate lymphoid cells, M2 macrophages and dendritic cells, regulating lipid metabolism and directly inducing effector gene expression. Moreover, preclinical models of allergy in gene-targeted mice have increasingly implicated PPAR-γ in driving allergic inflammation. Herein, we highlight the contrasting roles of PPAR-γ in allergic inflammation and hypothesize that the availability of environmental ligands for PPAR-γ may be at the heart of the rise in allergic diseases worldwide.

Original languageEnglish
JournalCurrent Allergy and Asthma Reports
Issue number11
Pages (from-to)45
Publication statusPublished - 25 Oct 2021
Externally publishedYes

Bibliographical note

© 2021. The Author(s).

    Research areas

  • Animals, Asthma, Humans, Hypersensitivity, Immunity, Innate, Lymphocytes, Mice, PPAR gamma/genetics

ID: 356968370