The Role of PPAR-γ in Allergic Disease
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The Role of PPAR-γ in Allergic Disease. / Stark, Julian M; Coquet, Jonathan M; Tibbitt, Christopher A.
In: Current Allergy and Asthma Reports, Vol. 21, No. 11, 25.10.2021, p. 45.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The Role of PPAR-γ in Allergic Disease
AU - Stark, Julian M
AU - Coquet, Jonathan M
AU - Tibbitt, Christopher A
N1 - © 2021. The Author(s).
PY - 2021/10/25
Y1 - 2021/10/25
N2 - PURPOSE OF REVIEW: The incidence of allergic diseases such as asthma, rhinitis and atopic dermatitis has risen at an alarming rate over the last century. Thus, there is a clear need to understand the critical factors that drive such pathologic immune responses. Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a nuclear receptor that has emerged as an important regulator of multiple cell types involved in the inflammatory response to allergens; from airway epithelial cells to T Helper (TH) cells.RECENT FINDINGS: Initial studies suggested that agonists of PPAR-γ could be employed to temper allergic inflammation, suppressing pro-inflammatory gene expression programs in epithelial cells. Several lines of work now suggest that PPAR-γ plays an essential in promoting 'type 2' immune responses that are typically associated with allergic disease. PPAR-γ has been found to promote the functions of TH2 cells, type 2 innate lymphoid cells, M2 macrophages and dendritic cells, regulating lipid metabolism and directly inducing effector gene expression. Moreover, preclinical models of allergy in gene-targeted mice have increasingly implicated PPAR-γ in driving allergic inflammation. Herein, we highlight the contrasting roles of PPAR-γ in allergic inflammation and hypothesize that the availability of environmental ligands for PPAR-γ may be at the heart of the rise in allergic diseases worldwide.
AB - PURPOSE OF REVIEW: The incidence of allergic diseases such as asthma, rhinitis and atopic dermatitis has risen at an alarming rate over the last century. Thus, there is a clear need to understand the critical factors that drive such pathologic immune responses. Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a nuclear receptor that has emerged as an important regulator of multiple cell types involved in the inflammatory response to allergens; from airway epithelial cells to T Helper (TH) cells.RECENT FINDINGS: Initial studies suggested that agonists of PPAR-γ could be employed to temper allergic inflammation, suppressing pro-inflammatory gene expression programs in epithelial cells. Several lines of work now suggest that PPAR-γ plays an essential in promoting 'type 2' immune responses that are typically associated with allergic disease. PPAR-γ has been found to promote the functions of TH2 cells, type 2 innate lymphoid cells, M2 macrophages and dendritic cells, regulating lipid metabolism and directly inducing effector gene expression. Moreover, preclinical models of allergy in gene-targeted mice have increasingly implicated PPAR-γ in driving allergic inflammation. Herein, we highlight the contrasting roles of PPAR-γ in allergic inflammation and hypothesize that the availability of environmental ligands for PPAR-γ may be at the heart of the rise in allergic diseases worldwide.
KW - Animals
KW - Asthma
KW - Humans
KW - Hypersensitivity
KW - Immunity, Innate
KW - Lymphocytes
KW - Mice
KW - PPAR gamma/genetics
U2 - 10.1007/s11882-021-01022-x
DO - 10.1007/s11882-021-01022-x
M3 - Review
C2 - 34697644
VL - 21
SP - 45
JO - Current Allergy & Asthma Reports
JF - Current Allergy & Asthma Reports
SN - 1529-7322
IS - 11
ER -
ID: 356968370