The association between malaria parasitaemia, erythrocyte polymorphisms, malnutrition and anaemia in children less than 10 years in Senegal: a case control study
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The association between malaria parasitaemia, erythrocyte polymorphisms, malnutrition and anaemia in children less than 10 years in Senegal : a case control study. / Tine, Roger C K; Ndiaye, Magatte; Hansson, Helle Holm; Ndour, Cheikh T; Faye, Babacar; Alifrangis, Michael; Sylla, K; Ndiaye, Jean L; Magnussen, Pascal; Bygbjerg, Ib C; Gaye, Oumar.
In: BMC Research Notes, Vol. 5, No. 1, 2012, p. 565.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The association between malaria parasitaemia, erythrocyte polymorphisms, malnutrition and anaemia in children less than 10 years in Senegal
T2 - a case control study
AU - Tine, Roger C K
AU - Ndiaye, Magatte
AU - Hansson, Helle Holm
AU - Ndour, Cheikh T
AU - Faye, Babacar
AU - Alifrangis, Michael
AU - Sylla, K
AU - Ndiaye, Jean L
AU - Magnussen, Pascal
AU - Bygbjerg, Ib C
AU - Gaye, Oumar
PY - 2012
Y1 - 2012
N2 - BACKGROUND:Malaria and anaemia (Haemoglobin= 11 g/dl. For each participant, a physical examination was done and anthropometric data collected prior to a biological assessment which included: malaria parasitaemia infection, intestinal worm carriage, G6PD deficiency, sickle cell disorders, and alpha-talassaemia.RESULTS:Three hundred and fifty two children 5 years (aOR=0.03, 95%CI0.01-0.08]). Stratified by age group, anaemia was significantly associated with stunting in children less than 5 years (aOR=3.1 95%CI1.4 -- 6.8]), with, sickle cell disorders (aOR=3.5 95%CI 1.4 -- 9.0]), alpha-thalassemia (or=2.4 95%CI1.1--5.3]) and stunting (aOR=3.6 95%CI 1.6--8.2]) for children above 5 years. No association was found between G6PD deficiency, intestinal worm carriage and children's gender.CONCLUSION:Malaria parasitaemia, stunting and haemoglobin genetic disorders represented the major causes of anaemia among study participants. Anaemia control in this area could be achieved by developing integrated interventions targeting both malaria and malnutrition.
AB - BACKGROUND:Malaria and anaemia (Haemoglobin= 11 g/dl. For each participant, a physical examination was done and anthropometric data collected prior to a biological assessment which included: malaria parasitaemia infection, intestinal worm carriage, G6PD deficiency, sickle cell disorders, and alpha-talassaemia.RESULTS:Three hundred and fifty two children 5 years (aOR=0.03, 95%CI0.01-0.08]). Stratified by age group, anaemia was significantly associated with stunting in children less than 5 years (aOR=3.1 95%CI1.4 -- 6.8]), with, sickle cell disorders (aOR=3.5 95%CI 1.4 -- 9.0]), alpha-thalassemia (or=2.4 95%CI1.1--5.3]) and stunting (aOR=3.6 95%CI 1.6--8.2]) for children above 5 years. No association was found between G6PD deficiency, intestinal worm carriage and children's gender.CONCLUSION:Malaria parasitaemia, stunting and haemoglobin genetic disorders represented the major causes of anaemia among study participants. Anaemia control in this area could be achieved by developing integrated interventions targeting both malaria and malnutrition.
KW - Anemia
KW - Anemia, Sickle Cell
KW - Animals
KW - Case-Control Studies
KW - Child
KW - Child, Preschool
KW - Entamoeba
KW - Erythrocytes
KW - Female
KW - Giardia lamblia
KW - Glucosephosphate Dehydrogenase
KW - Hemoglobins
KW - Humans
KW - Infant
KW - Malaria
KW - Male
KW - Malnutrition
KW - Parasitemia
KW - Polymorphism, Genetic
KW - Risk Factors
KW - Schistosoma haematobium
KW - Schistosoma mansoni
KW - Senegal
KW - Strongyloides stercoralis
KW - alpha-Thalassemia
U2 - 10.1186/1756-0500-5-565
DO - 10.1186/1756-0500-5-565
M3 - Journal article
C2 - 23057857
VL - 5
SP - 565
JO - BMC Research Notes
JF - BMC Research Notes
SN - 1756-0500
IS - 1
ER -
ID: 41828682