Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Department of Immunology and Microbiology

Research output: Contribution to journal › Journal article › Research › peer-review

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Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization. / Cele, Sandile; Jackson, Laurelle; Khoury, David S.; Khan, Khadija; Moyo-Gwete, Thandeka; Tegally, Houriiyah; San, James Emmanuel; Cromer, Deborah; Scheepers, Cathrine; Amoako, Daniel G.; Karim, Farina; Bernstein, Mallory; Lustig, Gila; Archary, Derseree; Smith, Muneerah; Ganga, Yashica; Jule, Zesuliwe; Reedoy, Kajal; Hwa, Shi Hsia; Giandhari, Jennifer; Blackburn, Jonathan M.; Gosnell, Bernadett I.; Abdool Karim, Salim S.; Hanekom, Willem; Davies, Mary Ann; Hsiao, Marvin; Martin, Darren; Mlisana, Koleka; Wibmer, Constantinos Kurt; Williamson, Carolyn; York, Denis; Harrichandparsad, Rohen; Herbst, Kobus; Jeena, Prakash; Khoza, Thandeka; Kløverpris, Henrik; Leslie, Alasdair; Madansein, Rajhmun; Magula, Nombulelo; Manickchund, Nithendra; Marakalala, Mohlopheni; Mazibuko, Matilda; Moshabela, Mosa; Mthabela, Ntombifuthi; Naidoo, Kogie; Ndhlovu, Zaza; Ndung’u, Thumbi; Ngcobo, Nokuthula; Nyamande, Kennedy; Patel, Vinod; NGS-SA; COMMIT-KZN Team.

In: Nature, Vol. 602, No. 7898, 2022, p. 654-656.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Cele, S, Jackson, L, Khoury, DS, Khan, K, Moyo-Gwete, T, Tegally, H, San, JE, Cromer, D, Scheepers, C, Amoako, DG, Karim, F, Bernstein, M, Lustig, G, Archary, D, Smith, M, Ganga, Y, Jule, Z, Reedoy, K, Hwa, SH, Giandhari, J, Blackburn, JM, Gosnell, BI, Abdool Karim, SS, Hanekom, W, Davies, MA, Hsiao, M, Martin, D, Mlisana, K, Wibmer, CK, Williamson, C, York, D, Harrichandparsad, R, Herbst, K, Jeena, P, Khoza, T, Kløverpris, H, Leslie, A, Madansein, R, Magula, N, Manickchund, N, Marakalala, M, Mazibuko, M, Moshabela, M, Mthabela, N, Naidoo, K, Ndhlovu, Z, Ndung’u, T, Ngcobo, N, Nyamande, K, Patel, V, NGS-SA & COMMIT-KZN Team 2022, 'Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization', Nature, vol. 602, no. 7898, pp. 654-656. https://doi.org/10.1038/s41586-021-04387-1

APA

Cele, S., Jackson, L., Khoury, D. S., Khan, K., Moyo-Gwete, T., Tegally, H., San, J. E., Cromer, D., Scheepers, C., Amoako, D. G., Karim, F., Bernstein, M., Lustig, G., Archary, D., Smith, M., Ganga, Y., Jule, Z., Reedoy, K., Hwa, S. H., ... COMMIT-KZN Team (2022). Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization. Nature, 602(7898), 654-656. https://doi.org/10.1038/s41586-021-04387-1

Vancouver

Cele S, Jackson L, Khoury DS, Khan K, Moyo-Gwete T, Tegally H et al. Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization. Nature. 2022;602(7898):654-656. https://doi.org/10.1038/s41586-021-04387-1

Author

Cele, Sandile ; Jackson, Laurelle ; Khoury, David S. ; Khan, Khadija ; Moyo-Gwete, Thandeka ; Tegally, Houriiyah ; San, James Emmanuel ; Cromer, Deborah ; Scheepers, Cathrine ; Amoako, Daniel G. ; Karim, Farina ; Bernstein, Mallory ; Lustig, Gila ; Archary, Derseree ; Smith, Muneerah ; Ganga, Yashica ; Jule, Zesuliwe ; Reedoy, Kajal ; Hwa, Shi Hsia ; Giandhari, Jennifer ; Blackburn, Jonathan M. ; Gosnell, Bernadett I. ; Abdool Karim, Salim S. ; Hanekom, Willem ; Davies, Mary Ann ; Hsiao, Marvin ; Martin, Darren ; Mlisana, Koleka ; Wibmer, Constantinos Kurt ; Williamson, Carolyn ; York, Denis ; Harrichandparsad, Rohen ; Herbst, Kobus ; Jeena, Prakash ; Khoza, Thandeka ; Kløverpris, Henrik ; Leslie, Alasdair ; Madansein, Rajhmun ; Magula, Nombulelo ; Manickchund, Nithendra ; Marakalala, Mohlopheni ; Mazibuko, Matilda ; Moshabela, Mosa ; Mthabela, Ntombifuthi ; Naidoo, Kogie ; Ndhlovu, Zaza ; Ndung’u, Thumbi ; Ngcobo, Nokuthula ; Nyamande, Kennedy ; Patel, Vinod ; NGS-SA ; COMMIT-KZN Team. / Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization. In: Nature. 2022 ; Vol. 602, No. 7898. pp. 654-656.

Bibtex

@article{50c35195a854485283f756d981893333,

title = "Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization",

abstract = "The emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B.1.1.529), first identified in Botswana and South Africa, may compromise vaccine effectiveness and lead to re-infections1. Here we investigated Omicron escape from neutralization by antibodies from South African individuals vaccinated with Pfizer BNT162b2. We used blood samples taken soon after vaccination from individuals who were vaccinated and previously infected with SARS-CoV-2 or vaccinated with no evidence of previous infection. We isolated and sequence-confirmed live Omicron virus from an infected person and observed that Omicron requires the angiotensin-converting enzyme 2 (ACE2) receptor to infect cells. We compared plasma neutralization of Omicron relative to an ancestral SARS-CoV-2 strain and found that neutralization of ancestral virus was much higher in infected and vaccinated individuals compared with the vaccinated-only participants. However, both groups showed a 22-fold reduction in vaccine-elicited neutralization by the Omicron variant. Participants who were vaccinated and had previously been infected exhibited residual neutralization of Omicron similar to the level of neutralization of the ancestral virus observed in the vaccination-only group. These data support the notion that reasonable protection against Omicron may be maintained using vaccination approaches.",

author = "Sandile Cele and Laurelle Jackson and Khoury, {David S.} and Khadija Khan and Thandeka Moyo-Gwete and Houriiyah Tegally and San, {James Emmanuel} and Deborah Cromer and Cathrine Scheepers and Amoako, {Daniel G.} and Farina Karim and Mallory Bernstein and Gila Lustig and Derseree Archary and Muneerah Smith and Yashica Ganga and Zesuliwe Jule and Kajal Reedoy and Hwa, {Shi Hsia} and Jennifer Giandhari and Blackburn, {Jonathan M.} and Gosnell, {Bernadett I.} and {Abdool Karim}, {Salim S.} and Willem Hanekom and Davies, {Mary Ann} and Marvin Hsiao and Darren Martin and Koleka Mlisana and Wibmer, {Constantinos Kurt} and Carolyn Williamson and Denis York and Rohen Harrichandparsad and Kobus Herbst and Prakash Jeena and Thandeka Khoza and Henrik Kl{\o}verpris and Alasdair Leslie and Rajhmun Madansein and Nombulelo Magula and Nithendra Manickchund and Mohlopheni Marakalala and Matilda Mazibuko and Mosa Moshabela and Ntombifuthi Mthabela and Kogie Naidoo and Zaza Ndhlovu and Thumbi Ndung{\textquoteright}u and Nokuthula Ngcobo and Kennedy Nyamande and Vinod Patel and NGS-SA and {COMMIT-KZN Team}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2022",

doi = "10.1038/s41586-021-04387-1",

language = "English",

volume = "602",

pages = "654--656",

journal = "Nature",

issn = "0028-0836",

publisher = "nature publishing group",

number = "7898",

}

RIS

TY - JOUR

T1 - Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

AU - Cele, Sandile

AU - Jackson, Laurelle

AU - Khoury, David S.

AU - Khan, Khadija

AU - Moyo-Gwete, Thandeka

AU - Tegally, Houriiyah

AU - San, James Emmanuel

AU - Cromer, Deborah

AU - Scheepers, Cathrine

AU - Amoako, Daniel G.

AU - Karim, Farina

AU - Bernstein, Mallory

AU - Lustig, Gila

AU - Archary, Derseree

AU - Smith, Muneerah

AU - Ganga, Yashica

AU - Jule, Zesuliwe

AU - Reedoy, Kajal

AU - Hwa, Shi Hsia

AU - Giandhari, Jennifer

AU - Blackburn, Jonathan M.

AU - Gosnell, Bernadett I.

AU - Abdool Karim, Salim S.

AU - Hanekom, Willem

AU - Davies, Mary Ann

AU - Hsiao, Marvin

AU - Martin, Darren

AU - Mlisana, Koleka

AU - Wibmer, Constantinos Kurt

AU - Williamson, Carolyn

AU - York, Denis

AU - Harrichandparsad, Rohen

AU - Herbst, Kobus

AU - Jeena, Prakash

AU - Khoza, Thandeka

AU - Kløverpris, Henrik

AU - Leslie, Alasdair

AU - Madansein, Rajhmun

AU - Magula, Nombulelo

AU - Manickchund, Nithendra

AU - Marakalala, Mohlopheni

AU - Mazibuko, Matilda

AU - Moshabela, Mosa

AU - Mthabela, Ntombifuthi

AU - Naidoo, Kogie

AU - Ndhlovu, Zaza

AU - Ndung’u, Thumbi

AU - Ngcobo, Nokuthula

AU - Nyamande, Kennedy

AU - Patel, Vinod

AU - NGS-SA

AU - COMMIT-KZN Team

PY - 2022

Y1 - 2022

N2 - The emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B.1.1.529), first identified in Botswana and South Africa, may compromise vaccine effectiveness and lead to re-infections1. Here we investigated Omicron escape from neutralization by antibodies from South African individuals vaccinated with Pfizer BNT162b2. We used blood samples taken soon after vaccination from individuals who were vaccinated and previously infected with SARS-CoV-2 or vaccinated with no evidence of previous infection. We isolated and sequence-confirmed live Omicron virus from an infected person and observed that Omicron requires the angiotensin-converting enzyme 2 (ACE2) receptor to infect cells. We compared plasma neutralization of Omicron relative to an ancestral SARS-CoV-2 strain and found that neutralization of ancestral virus was much higher in infected and vaccinated individuals compared with the vaccinated-only participants. However, both groups showed a 22-fold reduction in vaccine-elicited neutralization by the Omicron variant. Participants who were vaccinated and had previously been infected exhibited residual neutralization of Omicron similar to the level of neutralization of the ancestral virus observed in the vaccination-only group. These data support the notion that reasonable protection against Omicron may be maintained using vaccination approaches.

AB - The emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B.1.1.529), first identified in Botswana and South Africa, may compromise vaccine effectiveness and lead to re-infections1. Here we investigated Omicron escape from neutralization by antibodies from South African individuals vaccinated with Pfizer BNT162b2. We used blood samples taken soon after vaccination from individuals who were vaccinated and previously infected with SARS-CoV-2 or vaccinated with no evidence of previous infection. We isolated and sequence-confirmed live Omicron virus from an infected person and observed that Omicron requires the angiotensin-converting enzyme 2 (ACE2) receptor to infect cells. We compared plasma neutralization of Omicron relative to an ancestral SARS-CoV-2 strain and found that neutralization of ancestral virus was much higher in infected and vaccinated individuals compared with the vaccinated-only participants. However, both groups showed a 22-fold reduction in vaccine-elicited neutralization by the Omicron variant. Participants who were vaccinated and had previously been infected exhibited residual neutralization of Omicron similar to the level of neutralization of the ancestral virus observed in the vaccination-only group. These data support the notion that reasonable protection against Omicron may be maintained using vaccination approaches.

U2 - 10.1038/s41586-021-04387-1

DO - 10.1038/s41586-021-04387-1

M3 - Journal article

C2 - 35016196

AN - SCOPUS:85122689652

VL - 602

SP - 654

EP - 656

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7898

ER -

ID: 305717771