miRNA Signature in Early-stage Mycosis Fungoides

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Altered miRNA expressions are assigned pathoge-nic properties in several cancers including mycosis fungoides and could play a role in the early onset of the disease. The aim of this study was to exami-ne disease-specific miRNA expression in early-stage mycosis fungoides patch and plaque lesions. A quanti-tative real-time PCR platform of 384 human miRNAs was used to study miRNA expression in 154 diagnostic mycosis fungoides biopsies. A total of 110 miRNAs were significantly differentially expressed (>2-fold, p < 0.05) between plaque lesions and healthy con-trols, and 90 miRNAs (>2-fold, p < 0.05) differed between patch lesions and healthy controls. Moreover, 13 miRNAs differed in expression between patch and plaque lesions. Early-stage mycosis fungoides exhibited miRNA featur es that overlapped with those of psoria-sis. However, 39 miRNAs, including miR-142-3p, miR-150 and miR-146b, were specific to mycosis fungoides. In conclusion, early-stage mycosis fungoides expres-ses a distinct miRNA profile, indicating that miRNAs could play a role in the early development of mycosis fungoides.

Original languageEnglish
Article numberadv00785
JournalActa Dermato-Venereologica
Publication statusPublished - 2022

Bibliographical note

Publisher Copyright:
© 2022, Medical Journals/Acta D-V. All rights reserved.

    Research areas

  • cancer, cutaneous T-cell lymphoma, microRNA, mycosis fungoides

ID: 323858408