Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection
Research output: Contribution to journal › Journal article › Research › peer-review
Documents
- Distinct Immunoglobulin Fc Glycosylation Patterns Are
Final published version, 1.98 MB, PDF document
A prophylactic HIV vaccine would ideally induce protective immunity prior to sexual debut. Children develop broadly neutralizing antibody (bnAb) responses faster and at higher frequencies than adults, but little is known about the underlying mechanisms or the potential role of Fc-mediated effector functions in disease progression. We therefore performed systems immunology, with immunoglobulin profiling, on HIV-infected children with progressive and nonprogressive disease. Pediatric nonprogressors (PNPs) showed distinct immunoglobulin profiles with an increased ability to elicit potent Fc-mediated natural killer (NK)-cell effector functions. In contrast to previous reports in adults, both groups of children showed high levels of gp120-specific IgG Fc glycan sialylation compared to bulk IgG. Importantly, higher levels of Fc glycan sialylation were associated with increased bnAb breadth, providing the first evidence that Fc sialylation may drive affinity maturation of HIV-specific antibodies in children, a mechanism that could be exploited for vaccination strategies.
Original language | English |
---|---|
Article number | e00880-20 |
Journal | mSphere |
Volume | 5 |
Issue number | 6 |
Pages (from-to) | 1-16 |
ISSN | 2379-5042 |
DOIs | |
Publication status | Published - 2020 |
Bibliographical note
Publisher Copyright:
© 2020 Muenchhoff et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
- broadly neutralizing antibodies (bnAbs), Fc effector functions, Fc glycosylation, HIV, nonneutralizing antibodies, pediatric, vaccine
Research areas
ID: 271603736