A vaccine displaying a trimeric influenza-A HA stem protein on capsid-like particles elicits potent and long-lasting protection in mice

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A vaccine displaying a trimeric influenza-A HA stem protein on capsid-like particles elicits potent and long-lasting protection in mice. / Thrane, Susan; Aves, Kara-Lee; Uddbäck, Ida E M; Janitzek, Christoph M; Han, Julianna; Yang, Yuhe R; Ward, Andrew B; Theander, Thor G; Nielsen, Morten A; Salanti, Ali; Thomsen, Allan R; Christensen, Jan P; Sander, Adam F.

In: Vaccines, Vol. 8, No. 3, 389, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Thrane, S, Aves, K-L, Uddbäck, IEM, Janitzek, CM, Han, J, Yang, YR, Ward, AB, Theander, TG, Nielsen, MA, Salanti, A, Thomsen, AR, Christensen, JP & Sander, AF 2020, 'A vaccine displaying a trimeric influenza-A HA stem protein on capsid-like particles elicits potent and long-lasting protection in mice', Vaccines, vol. 8, no. 3, 389. https://doi.org/10.3390/vaccines8030389

APA

Thrane, S., Aves, K-L., Uddbäck, I. E. M., Janitzek, C. M., Han, J., Yang, Y. R., Ward, A. B., Theander, T. G., Nielsen, M. A., Salanti, A., Thomsen, A. R., Christensen, J. P., & Sander, A. F. (2020). A vaccine displaying a trimeric influenza-A HA stem protein on capsid-like particles elicits potent and long-lasting protection in mice. Vaccines, 8(3), [389]. https://doi.org/10.3390/vaccines8030389

Vancouver

Thrane S, Aves K-L, Uddbäck IEM, Janitzek CM, Han J, Yang YR et al. A vaccine displaying a trimeric influenza-A HA stem protein on capsid-like particles elicits potent and long-lasting protection in mice. Vaccines. 2020;8(3). 389. https://doi.org/10.3390/vaccines8030389

Author

Thrane, Susan ; Aves, Kara-Lee ; Uddbäck, Ida E M ; Janitzek, Christoph M ; Han, Julianna ; Yang, Yuhe R ; Ward, Andrew B ; Theander, Thor G ; Nielsen, Morten A ; Salanti, Ali ; Thomsen, Allan R ; Christensen, Jan P ; Sander, Adam F. / A vaccine displaying a trimeric influenza-A HA stem protein on capsid-like particles elicits potent and long-lasting protection in mice. In: Vaccines. 2020 ; Vol. 8, No. 3.

Bibtex

@article{4d0318861db94f5c8feb65aceb08d056,
title = "A vaccine displaying a trimeric influenza-A HA stem protein on capsid-like particles elicits potent and long-lasting protection in mice",
abstract = "Due to constant antigenic drift and shift, current influenza-A vaccines need to be redesigned and administered annually. A universal flu vaccine (UFV) that provides long-lasting protection against both seasonal and emerging pandemic influenza strains is thus urgently needed. The hemagglutinin (HA) stem antigen is a promising target for such a vaccine as it contains neutralizing epitopes, known to induce cross-protective IgG responses against a wide variety of influenza subtypes. In this study, we describe the development of a UFV candidate consisting of a HAstem trimer displayed on the surface of rigid capsid-like particles (CLP). Compared to soluble unconjugated HAstem trimer, the CLP-HAstem particles induced a more potent, long-lasting immune response and were able to protect mice against both homologous and heterologous H1N1 influenza challenge, even after a single dose.",
author = "Susan Thrane and Kara-Lee Aves and Uddb{\"a}ck, {Ida E M} and Janitzek, {Christoph M} and Julianna Han and Yang, {Yuhe R} and Ward, {Andrew B} and Theander, {Thor G} and Nielsen, {Morten A} and Ali Salanti and Thomsen, {Allan R} and Christensen, {Jan P} and Sander, {Adam F}",
year = "2020",
doi = "10.3390/vaccines8030389",
language = "English",
volume = "8",
journal = "Vaccines",
issn = "2076-393X",
publisher = "MDPI AG",
number = "3",

}

RIS

TY - JOUR

T1 - A vaccine displaying a trimeric influenza-A HA stem protein on capsid-like particles elicits potent and long-lasting protection in mice

AU - Thrane, Susan

AU - Aves, Kara-Lee

AU - Uddbäck, Ida E M

AU - Janitzek, Christoph M

AU - Han, Julianna

AU - Yang, Yuhe R

AU - Ward, Andrew B

AU - Theander, Thor G

AU - Nielsen, Morten A

AU - Salanti, Ali

AU - Thomsen, Allan R

AU - Christensen, Jan P

AU - Sander, Adam F

PY - 2020

Y1 - 2020

N2 - Due to constant antigenic drift and shift, current influenza-A vaccines need to be redesigned and administered annually. A universal flu vaccine (UFV) that provides long-lasting protection against both seasonal and emerging pandemic influenza strains is thus urgently needed. The hemagglutinin (HA) stem antigen is a promising target for such a vaccine as it contains neutralizing epitopes, known to induce cross-protective IgG responses against a wide variety of influenza subtypes. In this study, we describe the development of a UFV candidate consisting of a HAstem trimer displayed on the surface of rigid capsid-like particles (CLP). Compared to soluble unconjugated HAstem trimer, the CLP-HAstem particles induced a more potent, long-lasting immune response and were able to protect mice against both homologous and heterologous H1N1 influenza challenge, even after a single dose.

AB - Due to constant antigenic drift and shift, current influenza-A vaccines need to be redesigned and administered annually. A universal flu vaccine (UFV) that provides long-lasting protection against both seasonal and emerging pandemic influenza strains is thus urgently needed. The hemagglutinin (HA) stem antigen is a promising target for such a vaccine as it contains neutralizing epitopes, known to induce cross-protective IgG responses against a wide variety of influenza subtypes. In this study, we describe the development of a UFV candidate consisting of a HAstem trimer displayed on the surface of rigid capsid-like particles (CLP). Compared to soluble unconjugated HAstem trimer, the CLP-HAstem particles induced a more potent, long-lasting immune response and were able to protect mice against both homologous and heterologous H1N1 influenza challenge, even after a single dose.

U2 - 10.3390/vaccines8030389

DO - 10.3390/vaccines8030389

M3 - Journal article

C2 - 32679905

VL - 8

JO - Vaccines

JF - Vaccines

SN - 2076-393X

IS - 3

M1 - 389

ER -

ID: 245194291