Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model
Research output: Contribution to journal › Journal article › Research › peer-review
For any controlled human infection model (CHIM), a safe, standardized, and biologically relevant challenge inoculum is necessary. For hepatitis C virus (HCV) CHIM, we propose that human-derived high-titer inocula of several viral genotypes with extensive virologic, serologic, and molecular characterizations should be the most appropriate approach. These inocula should first be tested in human volunteers in a step-wise manner to ensure safety, reproducibility, and curability prior to using them for testing the efficacy of candidate vaccines.
Original language | English |
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Journal | Clinical Infectious Diseases |
Volume | 77 |
Pages (from-to) | S257-S261 |
ISSN | 1058-4838 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Publisher Copyright:
© 2023 Oxford University Press. All rights reserved.
- acute hepatitis, risk-benefit analysis, treatment, vaccine development
Research areas
ID: 368654711