Jannick Prentø
Associate Professor
Virology
Kettegård Allé 30, 2650 Hvidovre, 07 Bygning 7, Building: 07-13-62
Member of:
- 2008
- Published
Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization
Scheel, Troels Kasper Høyer, Gottwein, Judith Margarete, Jensen, T. B., Prentø, Jannick, Høegh, A. M., Alter, H. J., Eugen-Olsen, J. & Bukh, Jens, 2008, In: Proceedings of the National Academy of Science of the United States of America. 105, 3, p. 997-1002 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
DELETION OF HYPERVARIABLE REGION 1 (HVR1) OF E2 FROM HCV GENOTYPES 1-6 HAS DIFFERENTIAL EFFECT ON INFECTIVITY IN VITRO AND CAUSES INCREASED SUSCEPTIBILITY TO NEUTRALIZATION
Prentø, Jannick, Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Jensen, T. B., Serre, S. & Bukh, Jens, 2009, In: Journal of Hepatology. 50, p. S34-S34Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs
Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Jensen, T. B., Lademann, J. B., Prentø, Jannick, Knudsen, M. L., Hoegh, A. M. & Bukh, Jens, 2009, In: Hepatology. 49, 2, p. 364-77 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MONOCISTRONIC HEPATITIS C REPORTER VIRUS RECOMBINANTS OF ALL MAJOR GENOTYPES EXPRESSING ENHANCED GREEN FLUORESCENT PROTEIN TAGGED NS5A PROTEIN
Gottwein, Judith Margarete, Lademann, J. B., Scheel, Troels Kasper Høyer, Jensen, T. B., Prentø, Jannick & Bukh, Jens, 2009, In: Journal of Hepatology. 50, p. S33-S33Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Hepatitis C virus expressing flag-tagged envelope protein 2 has unaltered infectivity and density, is specifically neutralized by flag antibodies and can be purified by affinity chromatography
Prentø, Jannick & Bukh, Jens, 2011, In: Virology. 409, 2, p. 148-55Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization
Prentø, Jannick, Jensen, T. B., Meuleman, P., Serre, S., Scheel, Troels Kasper Høyer, Leroux-Roels, G., Gottwein, J. & Bukh, Jens, 2011, In: Journal of Virology. 85, 5, p. 2224-34 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step
Sabo, M. C., Luca, V. C., Prentø, Jannick, Hopcraft, S. E., Blight, K. J., Yi, M., Lemon, S. M., Ball, J. K., Bukh, Jens, Evans, M. J., Fremont, D. H. & Diamond, M. S., 2011, In: Journal of Virology. 85, 14, p. 7005-19 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems
Scheel, Troels Kasper Høyer, Prentø, Jannick, Carlsen, T. H. R., Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, 2012, In: P L o S Pathogens. 8, 5, p. 1-16 17 p., e1002696.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate
Keck, Z., Xia, J., Wang, Y., Wang, W., Krey, T., Prentø, Jannick, Carlsen, T., Li, A. Y., Patel, A. H., Lemon, S. M., Bukh, Jens, Rey, F. A. & Foung, S. K. H., 2012, In: P L o S Pathogens. 8, 4, 21 p., e1002653.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
Giang, E., Dorner, M., Prentø, Jannick, Dreux, M., Evans, M. J., Bukh, Jens, Rice, C. M., Ploss, A., Burton, D. R. & Law, M., 17 Apr 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6205-10 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein
Keck, Z., Wang, W., Wang, Y., Lau, P., Carlsen, T. H. R., Prentø, Jannick, Xia, J., Patel, A. H., Bukh, Jens & Foung, S. K. H., 2013, In: Journal of Virology. 87, 1, p. 37-51 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutralization resistance of hepatitis C virus can be overcome by recombinant human monoclonal antibodies
Pedersen, J. L., Carlsen, T. H. R., Prentø, Jannick, Ramirez, S., Jensen, T. B., Forns, X., Alter, H., Foung, S. K. H., Law, M., Gottwein, Judith Margarete, Weis, Nina & Bukh, Jens, 2013, In: Hepatology. 58, 5, p. 1587-1597 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analysis of hepatitis C virus core/NS5A protein co-localization using novel cell culture systems expressing core-NS2 and NS5A of genotypes 1-7
Galli, A., Scheel, Troels Kasper Høyer, Prentø, Jannick, Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Oct 2013, In: The Journal of general virology. 94, Pt 10, p. 2221-35 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient cell culture system for hepatitis C virus genotype 1a and 1b: Patent #: 8,563,706
Scheel, T. K. H., Gottwein, Judith Margarete, Prentø, Jannick, Jensen, T. B. & Bukh, Jens, 22 Oct 2013, IPC No. C07H 21/00 (20060101); A61K 39/29 (20060101); A61K 39/12 (20060101); A61K 39/295 (20060101); C12N 7/00 (20060101), Patent No. WO2009/080053, 2 Jul 2009, Priority date 19 Dec 2008, Priority No. PCT/DK2008/050333Research output: Patent
- 2014
- Published
Hypervariable region 1 deletion and required adaptive envelope mutations confer decreased dependency on scavenger receptor class B type I and low-density lipoprotein receptor for hepatitis C virus
Prentø, Jannick, Serre, S. B. N., Ramirez, S., Nicosia, A. & Bukh, Jens, Feb 2014, In: Journal of Virology. 88, 3, p. 1725-39 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6
Mathiesen, C. K., Jensen, T. B., Prentø, Jannick, Krarup, H., Nicosia, A., Law, M., Bukh, Jens & Gottwein, Judith Margarete, Jun 2014, In: Virology. 458-459, p. 190-208 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus expressing reporter tagged NS5A protein: Patent #: 8,772,022
Gottwein, Judith Margarete, Scheel, T. K. H., Bukh, Jens, Prentø, Jannick & Jensen, T. B., 8 Jul 2014, IPC No. C12N 15/00 (20060101); C12N 5/00 (20060101); C12N 7/00 (20060101); C12N 15/64 (20060101); A61K 39/29 (20060101); C12N 7/01 (20060101), Patent No. WO2010/037403, 8 Apr 2010, Priority date 5 Oct 2009, Priority No. PCT/DK2009/050263Research output: Patent
- Published
Infectious genotype 1a, 1b, 2a, 2b, 3a, 5a, 6a and 7a hepatitis C virus lacking the hypervariable region 1 (HVR1): Patent #: 8,846,891
Prentø, Jannick, Gottwein, Judith Margarete, Scheel, T. K. H., Bukh, Jens & Jensen, T. B., 30 Sep 2014, IPC No. C07H 21/04 (20060101); C07H 21/02 (20060101), Patent No. WO2010/022727, 4 Mar 2010, Priority date 7 Aug 2009, Priority No. PCT/DK2009/050197Research output: Patent
- Published
Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a
Carlsen, T. H. R., Pedersen, J., Prentø, Jannick, Giang, E., Keck, Z., Mikkelsen, L. S., Law, M., Foung, S. K. H. & Bukh, Jens, Nov 2014, In: Hepatology. 60, 5, p. 1551-62 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant
Mathiesen, C. K., Prentø, Jannick, Meredith, L. W., Jensen, T. B., Krarup, H., McKeating, J. A., Gottwein, Judith Margarete & Bukh, Jens, Aug 2015, In: Journal of Virology. 89, 15, p. 7758-7775 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice
Prentø, Jannick, Verhoye, L., Moctezuma, R. V., Buysschaert, C., Farhoudi, A., Wang, R., Alter, H., Meuleman, P. & Bukh, Jens, Dec 2016, In: Gut. 65, 12, p. 1988-1997 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypervariable Region 1 Shielding of Hepatitis C Virus Is a Main Contributor to Genotypic Differences in Neutralization Sensitivity
Prentø, Jannick, Velazquez-Moctezuma, R., Foung, S. K. H., Law, M. & Bukh, Jens, Dec 2016, In: Hepatology. 64, 6, p. 1881-1892 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A
Velazquez-Moctezuma, R., Law, M., Bukh, Jens & Prentø, Jannick, Feb 2017, In: PLOS Pathogens. 13, 2, 29 p., 1006214.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals
Pihl, A. F., Offersgaard, A. F., Mathiesen, C. K., Prentø, Jannick, Fahnøe, Ulrik, Krarup, H., Bukh, Jens & Gottwein, Judith Margarete, 2018, In: Scientific Reports. 8, 1, 13 p., 17505.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry
Prentø, Jannick & Bukh, Jens, 2018, In: Frontiers in Immunology. 9, 11 p., 2146.Research output: Contribution to journal › Review › Research › peer-review
- Published
Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry
Riva, L., Song, O., Prentø, Jannick, Helle, F., L'homme, L., Gattolliat, C., Vandeputte, A., Feneant, L., Belouzard, S., Baumert, T. F., Asselah, T., Bukh, Jens, Brodin, P., Cocquerel, L., Rouille, Y. & Dubuisson, J., 1 May 2018, In: Journal of Virology. 92, 10, 19 p., e01982-17.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis c virus infections uncover molecular determinants for E2 targeting and vaccine design
Keck, Z. Y., Pierce, B. G., Lau, P., Lu, J., Wang, Y., Underwood, A., Bull, R. A., Prentø, Jannick, Velázquez-Moctezuma, R., Walker, Melanie Rose, Luciani, F., Guest, J. D., Fauvelle, C., Baumert, T. F., Bukh, Jens, Lloyd, A. R. & Foung, S. K. H., 2019, In: P L o S Pathogens. 15, 5, 28 p., e1007772.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies
Tzarum, N., Giang, E., Kong, L., He, L., Prentø, Jannick, Augestad, E., Hua, Y., Castillo, S., Lauer, G. M., Bukh, Jens, Zhu, J., Wilson, I. A. & Law, M., 2019, In: Science Advances. 5, 1, 12 p., eaav1882.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C Virus–Escape Studies for Human Monoclonal Antibody AR4A Reveal Isolate-Specific Resistance and a High Barrier to Resistance
Velázquez-moctezuma, R., Galli, Andrea, Law, M., Bukh, Jens & Prentø, Jannick, 2019, In: The Journal of Infectious Diseases. 219, 1, p. 68-79Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus escape studies of human antibody AR3a reveal a high barrier to resistance and novel insights on viral antibody evasion mechanisms
Velázquez-Moctezuma, R., Galli, Andrea, Law, M., Bukh, Jens & Prentø, Jannick, 2019, In: Journal of Virology. 93, 4, 27 p., e0190918.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations
Prentø, Jannick, Velázquez-Moctezuma, R., Augestad, E. H., Galli, Andrea, Wang, R., Law, M., Alter, H. & Bukh, Jens, 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10039-10047 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vitro neutralization assay using cultured hepatitis C virus
Prentø, Jannick & Bukh, Jens, 2019, Hepatitis C Virus Protocols. Humana Press, p. 433-439 7 p. (Methods in Molecular Biology, Vol. 1911).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2020
- Published
An alternate conformation of HCV E2 neutralizing face as an additional vaccine target
Tzarum, N., Giang, E., Kadam, R. U., Chen, F., Nagy, K., Augestad, E. H., Velázquez-Moctezuma, R., Keck, Z. Y., Hua, Y., Stanfield, R. L., Dreux, M., Prentø, Jannick, Foung, S. K. H., Bukh, Jens, Wilson, I. A. & Law, M., 2020, In: Science Advances. 6, 30, abb5642.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Global and local envelope protein dynamics of hepatitis C virus determine broad antibody sensitivity
Augestad, E. H., Castelli, M., Clementi, N., Ströh, L. J., Krey, T., Burioni, R., Mancini, N., Bukh, Jens & Prentø, Jannick, 2020, In: Science Advances. 6, 35, 13 p., eabb5938.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Specific antibodies induced by immunization with hepatitis B virus-like particles carrying hepatitis C virus envelope glycoprotein 2 epitopes show differential neutralization efficiency
Czarnota, A., Offersgaard, A., Pihl, A. F., Prentø, Jannick, Bukh, Jens, Gottwein, Judith Margarete, Bieńkowska-Szewczyk, K. & Grzyb, K., 2020, In: Vaccines. 8, 2, 19 p., 294.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
In vitro adaptation and characterization of attenuated hypervariable region 1 swap chimeras of hepatitis C virus
Olesen, C. H., Augestad, Elias Honerød, Troise, F., Bukh, Jens & Prentø, Jannick, 2021, In: PLOS Pathogens. 17, July, 29 p., e1009720.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens
Prentø, Jannick, Janitzek, C. M., Velázquez-Moctezuma, R., Goksøyr, L., Olsen, Rebecca Wendelboe, Fanalista, Margherita, Augestad, Elias Honerød, Thrane, Susan, Pihl, A. F., Gottwein, Judith Margarete, Sander, Adam F. & Bukh, Jens, 2021, In: PLoS ONE. 16, e0255336.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins
Chen, F., Tzarum, N., Lin, X., Giang, E., Velázquez-Moctezuma, R., Augestad, Elias Honerød, Nagy, K., He, L., Hernandez, M., Fouch, M. E., Grinyó, A., Chavez, D., Doranz, B. J., Prentø, Jannick, Stanfield, R. L., Lanford, R., Bukh, Jens, Wilson, I. A., Zhu, J. & Law, M., 2021, In: Immunity. 54, 4, p. 781-796.e4Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus envelope protein dynamics and the link to hypervariable region 1
Augestad, Elias Honerød, Bukh, Jens & Prentø, Jannick, 2021, In: Current Opinion in Virology. 50, p. 69-75 7 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Mechanisms of hepatitis C virus escape from vaccine-relevant neutralizing antibodies
Velázquez-Moctezuma, R., Augestad, Elias Honerød, Castelli, M., Olesen, C. H., Clementi, N., Clementi, M., Mancini, N. & Prentø, Jannick, 2021, In: Vaccines. 9, 3, 291.Research output: Contribution to journal › Review › Research › peer-review
- 2022
- Published
Inactivated whole hepatitis C virus vaccine employing a licensed adjuvant elicits cross-genotype neutralizing antibodies in mice
Pihl, A. F., Feng, S., Offersgaard, Anna Falden, Alzua, G. P., Augestad, Elias Honerød, Mathiesen, C. K., Jensen, T. B., Krarup, H., Law, M., Prentø, Jannick, Christensen, Jan Pravsgaard, Bukh, Jens & Gottwein, Judith Margarete, 2022, In: Journal of Hepatology. 76, 5, p. 1051-1061Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel HCV Genotype 4d Infectious Systems and Assessment of Direct-Acting Antivirals and Antibody Neutralization
Pham, Long, Velázquez-Moctezuma, R., Fahnøe, Ulrik, Collignon, Laura Maria F, Bajpai, P., Sølund, C., Weis, Nina, Holmbeck, Kenn, Prentø, Jannick & Bukh, Jens, 2022, In: Viruses. 14, 11, 2527.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Two-component vaccine consisting of virus-like particles displaying hepatitis C virus envelope protein 2 oligomers
Prentø, Jannick, Janitzek, C. M., Velázquez-Moctezuma, R., Sørensen, Andreas Holst Holmegaard, Jørgensen, T., Clemmensen, S., Soroka, V., Thrane, Susan, Theander, Thor Grundtvig, Nielsen, Morten Agertoug, Salanti, Ali, Bukh, Jens & Sander, Adam F. , 2022, In: npj Vaccines. 7, 148.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Identification of novel neutralizing determinants for protection against HCV
Alzua, G. P., Pihl, A. F., Offersgaard, Anna Falden, Velázquez-Moctezuma, R., Duarte Hernandez, Carlos Rene, Augestad, Elias Honerød, Fahnøe, Ulrik, Mathiesen, C. K., Krarup, H., Law, M., Prentø, Jannick, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: Hepatology. 73, 3, p. 982-996Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inactivated genotype 1a, 2a and 3a HCV vaccine candidates induced broadly neutralising antibodies in mice
Alzua, G. P., Pihl, A. F., Offersgaard, Anna Falden, Duarte Hernandez, Carlos Rene, Duan, Z., Feng, S., Fahnøe, Ulrik, Sølund, C., Weis, Nina, Law, M., Prentø, Jannick, Christensen, Jan Pravsgaard, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: Gut. 72, 3, p. 560-572Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5475739
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382
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Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
344
downloads
Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry
Research output: Contribution to journal › Review › Research › peer-review
Published -
191
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Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis c virus infections uncover molecular determinants for E2 targeting and vaccine design
Research output: Contribution to journal › Journal article › Research › peer-review
Published