Advantages and Prospects of Tag/Catcher Mediated Antigen Display on Capsid-Like Particle-Based Vaccines
Research output: Contribution to journal › Review › Research › peer-review
Documents
- Advantages and Prospects of Tag/Catcher Mediated Antigen Display on Capsid-Like Particle-Based Vaccines
Final published version, 388 KB, PDF document
Capsid-like particles (CLPs) are multimeric, repetitive assemblies of recombinant viral capsid proteins, which are highly immunogenic due to their structural similarity to wild-type viruses. CLPs can be used as molecular scaffolds to enable the presentation of soluble vaccine antigens in a similar structural format, which can significantly increase the immunogenicity of the antigen. CLP-based antigen display can be obtained by various genetic and modular conjugation methods. However, these vary in their versatility as well as efficiency in achieving an immunogenic antigen display. Here, we make a comparative review of the major CLP-based antigen display technologies. The Tag/Catcher-AP205 platform is highlighted as a particularly versatile and efficient technology that offers new qualitative and practical advantages in designing modular CLP vaccines. Finally, we discuss how split-protein Tag/Catcher conjugation systems can help to further propagate and enhance modular CLP vaccine designs.
Original language | English |
---|---|
Article number | 185 |
Journal | Viruses |
Volume | 12 |
Issue number | 2 |
ISSN | 1999-4915 |
DOIs | |
Publication status | Published - 2020 |
- capsid, antigen display, virus-like particle, vaccine, platform
Research areas
Number of downloads are based on statistics from Google Scholar and www.ku.dk
ID: 236722537