Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection. / Muenchhoff, Maximilian; Adland, Emily; Karimanzira, Owen; Crowther, Carol; Pace, Matthew; Csala, Anna; Leitman, Ellen; Moonsamy, Angeline; McGregor, Callum; Hurst, Jacob; Groll, Andreas; Mori, Masahiko; Sinmyee, Smruti; Thobakgale, Christina; Tudor-Williams, Gareth; Prendergast, Andrew J.; Kloverpris, Henrik; Roider, Julia; Leslie, Alasdair; Shingadia, Delane; Brits, Thea; Daniels, Samantha; Frater, John; Willberg, Christian B.; Walker, Bruce D.; Ndung'u, Thumbi; Jooste, Pieter; Moore, Penny L.; Morris, Lynn; Goulder, Philip.

In: Science Translational Medicine, Vol. 8, No. 358, 358ra125, 28.09.2016.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Muenchhoff, M, Adland, E, Karimanzira, O, Crowther, C, Pace, M, Csala, A, Leitman, E, Moonsamy, A, McGregor, C, Hurst, J, Groll, A, Mori, M, Sinmyee, S, Thobakgale, C, Tudor-Williams, G, Prendergast, AJ, Kloverpris, H, Roider, J, Leslie, A, Shingadia, D, Brits, T, Daniels, S, Frater, J, Willberg, CB, Walker, BD, Ndung'u, T, Jooste, P, Moore, PL, Morris, L & Goulder, P 2016, 'Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection', Science Translational Medicine, vol. 8, no. 358, 358ra125. https://doi.org/10.1126/scitranslmed.aag1048

APA

Muenchhoff, M., Adland, E., Karimanzira, O., Crowther, C., Pace, M., Csala, A., Leitman, E., Moonsamy, A., McGregor, C., Hurst, J., Groll, A., Mori, M., Sinmyee, S., Thobakgale, C., Tudor-Williams, G., Prendergast, A. J., Kloverpris, H., Roider, J., Leslie, A., ... Goulder, P. (2016). Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection. Science Translational Medicine, 8(358), [358ra125]. https://doi.org/10.1126/scitranslmed.aag1048

Vancouver

Muenchhoff M, Adland E, Karimanzira O, Crowther C, Pace M, Csala A et al. Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection. Science Translational Medicine. 2016 Sep 28;8(358). 358ra125. https://doi.org/10.1126/scitranslmed.aag1048

Author

Muenchhoff, Maximilian ; Adland, Emily ; Karimanzira, Owen ; Crowther, Carol ; Pace, Matthew ; Csala, Anna ; Leitman, Ellen ; Moonsamy, Angeline ; McGregor, Callum ; Hurst, Jacob ; Groll, Andreas ; Mori, Masahiko ; Sinmyee, Smruti ; Thobakgale, Christina ; Tudor-Williams, Gareth ; Prendergast, Andrew J. ; Kloverpris, Henrik ; Roider, Julia ; Leslie, Alasdair ; Shingadia, Delane ; Brits, Thea ; Daniels, Samantha ; Frater, John ; Willberg, Christian B. ; Walker, Bruce D. ; Ndung'u, Thumbi ; Jooste, Pieter ; Moore, Penny L. ; Morris, Lynn ; Goulder, Philip. / Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection. In: Science Translational Medicine. 2016 ; Vol. 8, No. 358.

Bibtex

@article{225d4f453ccb41a18e9d61d97fe86ece,
title = "Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection",
abstract = "Disease-free infection in HIV-infected adults is associated with human leukocyte antigen-mediated suppression of viremia, whereas in the sooty mangabey and other healthy natural hosts of simian immunodeficiency virus (SIV), viral replication continues unabated. To better understand factors preventing HIV disease, we investigated pediatric infection, where AIDS typically develops more rapidly than in adults. Among 170 nonprogressing antiretroviral therapy-na{\"i}ve children aged >5 years maintaining normal-for-Age CD4 T cell counts, immune activation levels were low despite high viremia (median, 26,000 copies/ml). Potent, broadly neutralizing antibody responses in most of the subjects and strong virus-specific T cell activity were present but did not drive pediatric nonprogression. However, reduced CCR5 expression and low HIV infection in long-lived central memory CD4 T cells were observed in pediatric nonprogressors. These children therefore express two cardinal immunological features of nonpathogenic SIV infection in sooty mangabeys-low immune activation despite high viremia and low CCR5 expression on long-lived central memory CD4 T cells-suggesting closer similarities with nonpathogenetic mechanisms evolved over thousands of years in natural SIV hosts than those operating in HIV-infected adults.",
author = "Maximilian Muenchhoff and Emily Adland and Owen Karimanzira and Carol Crowther and Matthew Pace and Anna Csala and Ellen Leitman and Angeline Moonsamy and Callum McGregor and Jacob Hurst and Andreas Groll and Masahiko Mori and Smruti Sinmyee and Christina Thobakgale and Gareth Tudor-Williams and Prendergast, {Andrew J.} and Henrik Kloverpris and Julia Roider and Alasdair Leslie and Delane Shingadia and Thea Brits and Samantha Daniels and John Frater and Willberg, {Christian B.} and Walker, {Bruce D.} and Thumbi Ndung'u and Pieter Jooste and Moore, {Penny L.} and Lynn Morris and Philip Goulder",
year = "2016",
month = sep,
day = "28",
doi = "10.1126/scitranslmed.aag1048",
language = "English",
volume = "8",
journal = "Science Translational Medicine",
issn = "1946-6234",
publisher = "american association for the advancement of science",
number = "358",

}

RIS

TY - JOUR

T1 - Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection

AU - Muenchhoff, Maximilian

AU - Adland, Emily

AU - Karimanzira, Owen

AU - Crowther, Carol

AU - Pace, Matthew

AU - Csala, Anna

AU - Leitman, Ellen

AU - Moonsamy, Angeline

AU - McGregor, Callum

AU - Hurst, Jacob

AU - Groll, Andreas

AU - Mori, Masahiko

AU - Sinmyee, Smruti

AU - Thobakgale, Christina

AU - Tudor-Williams, Gareth

AU - Prendergast, Andrew J.

AU - Kloverpris, Henrik

AU - Roider, Julia

AU - Leslie, Alasdair

AU - Shingadia, Delane

AU - Brits, Thea

AU - Daniels, Samantha

AU - Frater, John

AU - Willberg, Christian B.

AU - Walker, Bruce D.

AU - Ndung'u, Thumbi

AU - Jooste, Pieter

AU - Moore, Penny L.

AU - Morris, Lynn

AU - Goulder, Philip

PY - 2016/9/28

Y1 - 2016/9/28

N2 - Disease-free infection in HIV-infected adults is associated with human leukocyte antigen-mediated suppression of viremia, whereas in the sooty mangabey and other healthy natural hosts of simian immunodeficiency virus (SIV), viral replication continues unabated. To better understand factors preventing HIV disease, we investigated pediatric infection, where AIDS typically develops more rapidly than in adults. Among 170 nonprogressing antiretroviral therapy-naïve children aged >5 years maintaining normal-for-Age CD4 T cell counts, immune activation levels were low despite high viremia (median, 26,000 copies/ml). Potent, broadly neutralizing antibody responses in most of the subjects and strong virus-specific T cell activity were present but did not drive pediatric nonprogression. However, reduced CCR5 expression and low HIV infection in long-lived central memory CD4 T cells were observed in pediatric nonprogressors. These children therefore express two cardinal immunological features of nonpathogenic SIV infection in sooty mangabeys-low immune activation despite high viremia and low CCR5 expression on long-lived central memory CD4 T cells-suggesting closer similarities with nonpathogenetic mechanisms evolved over thousands of years in natural SIV hosts than those operating in HIV-infected adults.

AB - Disease-free infection in HIV-infected adults is associated with human leukocyte antigen-mediated suppression of viremia, whereas in the sooty mangabey and other healthy natural hosts of simian immunodeficiency virus (SIV), viral replication continues unabated. To better understand factors preventing HIV disease, we investigated pediatric infection, where AIDS typically develops more rapidly than in adults. Among 170 nonprogressing antiretroviral therapy-naïve children aged >5 years maintaining normal-for-Age CD4 T cell counts, immune activation levels were low despite high viremia (median, 26,000 copies/ml). Potent, broadly neutralizing antibody responses in most of the subjects and strong virus-specific T cell activity were present but did not drive pediatric nonprogression. However, reduced CCR5 expression and low HIV infection in long-lived central memory CD4 T cells were observed in pediatric nonprogressors. These children therefore express two cardinal immunological features of nonpathogenic SIV infection in sooty mangabeys-low immune activation despite high viremia and low CCR5 expression on long-lived central memory CD4 T cells-suggesting closer similarities with nonpathogenetic mechanisms evolved over thousands of years in natural SIV hosts than those operating in HIV-infected adults.

U2 - 10.1126/scitranslmed.aag1048

DO - 10.1126/scitranslmed.aag1048

M3 - Journal article

C2 - 27683550

AN - SCOPUS:84989829797

VL - 8

JO - Science Translational Medicine

JF - Science Translational Medicine

SN - 1946-6234

IS - 358

M1 - 358ra125

ER -

ID: 169079906