A cVLP-based vaccine displaying full-length PCSK9 elicits a higher reduction in plasma PCSK9 than similar peptide-based cVLP vaccines
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A cVLP-based vaccine displaying full-length PCSK9 elicits a higher reduction in plasma PCSK9 than similar peptide-based cVLP vaccines. / Goksøyr, Louise; Skrzypczak, Magdalena; Sampson, Maureen; Nielsen, Morten A.; Salanti, Ali; Theander, Thor G.; Remaley, Alan T.; Jongh, Willem A. De; Sander, Adam F.
In: Vaccines, Vol. 11, No. 1, 2, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A cVLP-based vaccine displaying full-length PCSK9 elicits a higher reduction in plasma PCSK9 than similar peptide-based cVLP vaccines
AU - Goksøyr, Louise
AU - Skrzypczak, Magdalena
AU - Sampson, Maureen
AU - Nielsen, Morten A.
AU - Salanti, Ali
AU - Theander, Thor G.
AU - Remaley, Alan T.
AU - Jongh, Willem A. De
AU - Sander, Adam F.
PY - 2023
Y1 - 2023
N2 - Administration of PCSK9-specific monoclonal antibodies, as well as peptide-based PCSK9 vaccines, can lower plasma LDL cholesterol by blocking PCSK9. However, these treatments also cause an increase in plasma PCSK9 levels, presumably due to the formation of immune complexes. Here, we utilize a versatile capsid virus-like particle (cVLP)-based vaccine platform to deliver both full-length (FL) PCSK9 and PCSK9-derived peptide antigens, to investigate whether induction of a broader polyclonal anti-PCSK9 antibody response would mediate more efficient clearance of plasma PCSK9. This head-to-head immunization study reveals a significantly increased capacity of the FL PCSK9 cVLP vaccine to opsonize and clear plasma PCSK9. These findings may have implications for the design of PCSK9 and other vaccines that should effectively mediate opsonization and immune clearance of target antigens.
AB - Administration of PCSK9-specific monoclonal antibodies, as well as peptide-based PCSK9 vaccines, can lower plasma LDL cholesterol by blocking PCSK9. However, these treatments also cause an increase in plasma PCSK9 levels, presumably due to the formation of immune complexes. Here, we utilize a versatile capsid virus-like particle (cVLP)-based vaccine platform to deliver both full-length (FL) PCSK9 and PCSK9-derived peptide antigens, to investigate whether induction of a broader polyclonal anti-PCSK9 antibody response would mediate more efficient clearance of plasma PCSK9. This head-to-head immunization study reveals a significantly increased capacity of the FL PCSK9 cVLP vaccine to opsonize and clear plasma PCSK9. These findings may have implications for the design of PCSK9 and other vaccines that should effectively mediate opsonization and immune clearance of target antigens.
U2 - 10.3390/vaccines11010002
DO - 10.3390/vaccines11010002
M3 - Journal article
C2 - 36679847
VL - 11
JO - Vaccines
JF - Vaccines
SN - 2076-393X
IS - 1
M1 - 2
ER -
ID: 339995368