Henrik Nyhus Kløverpris
Associate Professor
Immunology
Nørre Allé 14
2200 København N
- 2007
- Published
Sequence conservation of subdominant HLA-A2-binding CTL epitopes in HIV-1 clinical isolates and CD8<sup>+</sup> T-lymphocyte cross-recognition may explain the immune reaction in infected individuals
Thorn, M., Tang, S., Therrien, D., Kløverpris, Henrik Nyhus, Vinner, Lasse, Kronborg, Gitte, Gerstoft, Jan, Corbet, S. & Fomsgaard, A., 2007, In: APMIS.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sequence conservation of subdominant HLA-A2-binding CTL epitopes in HIV-1 clinical isolates and CD8<sup>+</sup> T-lymphocyte cross-recognition may explain the immune reaction in infected individuals
Thorn, M., Tang, S., Therrien, D., Kløverpris, Henrik Nyhus, Vinner, Lasse, Kronborg, Gitte, Gerstoft, Jan, Corbet, S. & Fomsgaard, A., 2007, In: APMIS.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sequence conservation of subdominant HLA-A2-binding CTL epitopes in HIV-1 clinical isolates and CD8<sup>+</sup> T-lymphocyte cross-recognition may explain the immune reaction in infected individuals
Thorn, M., Tang, S., Therrien, D., Kløverpris, Henrik Nyhus, Vinner, Lasse, Kronborg, Gitte, Gerstoft, Jan, Corbet, S. & Fomsgaard, A., 2007, In: APMIS.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Efficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B*2705-restricted CD8+ T cells
Payne, R. P., Kløverpris, Henrik Nyhus, Sacha, J. B., Brumme, Z., Brumme, C., Buus, Søren, Sims, S., Hickling, S., Riddell, L., Chen, F., Luzzi, G., Edwards, A., Phillips, R., Prado, J. G. & Goulder, P. J. R., 2010, In: Journal of Virology. 84, 20, p. 10543-10557Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dimethyl sulfoxide (DMSO) exposure to human peripheral blood mononuclear cells (PBMCs) abolish T cell responses only in high concentrations and following coincubation for more than two hours
Kløverpris, Henrik Nyhus, Fomsgaard, A., Handley, A., Ackland, J., Sullivan, M. & Goulder, P., Apr 2010, In: Journal of Immunological Methods. 356, 1-2, p. 70-78 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
High frequency, sustained T cell responses to PARV4 suggest viral persistence in vivo
Simmons, R., Sharp, C., Sims, S., Kløverpris, Henrik Nyhus, Goulder, P., Simmonds, P., Bowness, P. & Klenerman, P., 2011, In: Journal of Infectious Diseases.Research output: Contribution to journal › Journal article › Research › peer-review
Sequence analysis of HIV-1 isolates from Guinea-Bissau: Selection of vaccine epitopes relevant in both West African and European countries
Vinner, Lasse, Holmgren, B., Jensen, K. J., Esbjornsson, J., Borggren, M., Hentze, J. L., Karlsson, I., Andresen, B. S., Gram, G. J., Kløverpris, Henrik Nyhus, Aaby, P., da Silva, Z. J., Fenyö, E. & Fomsgaard, A., 2011, In: APMIS. 119, 8, p. 487-497Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control
Kløverpris, Henrik Nyhus, Buus, Anette Stryhn, van der Stok, M., Harndahl, M., Payne, R. P., Matthews, P. C., Chen, F., Riddell, L., Walker, B. D., Ndung'u, T., Buus, Søren & Goulder, P., 2012, In: Journal of Virology. 86, 2, p. 919-29 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HIV control through a single nucleotide on the HLA-B locus
Kløverpris, Henrik Nyhus, Harndahl, M., Leslie, A. J., Carlson, J. M., Ismail, N., van der Stok, M., Huang, K. G., Chen, F., Riddell, L., Steyn, D., Goedhals, D., van Vuuren, C., Frater, J., Walker, B. D., Carrington, M., Ndung'u, T., Buus, Søren & Goulder, P., Nov 2012, In: Journal of Virology. 86, 21, p. 11493-11500 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of conserved subdominant HIV Type 1 CD8(+) T Cell epitopes restricted within common HLA Supertypes for therapeutic HIV Type 1 vaccines
Karlsson, I., Kløverpris, Henrik Nyhus, Jensen, K. J., Buus, Anette Stryhn, Buus, Søren, Karlsson, A., Vinner, L., Goulder, P. & Fomsgaard, A., Nov 2012, In: AIDS Research and Human Retroviruses. 28, 11, p. 1434-1443 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope
Matthews, P. C., Koyanagi, M., Kløverpris, H. N., Harndahl, M., Buus, A. S., Akahoshi, T., Gatanaga, H., Oka, S., Juarez Molina, C., Valenzuela Ponce, H., Avila Rios, S., Cole, D., Carlson, J., Payne, R. P., Ogwu, A., Bere, A., Ndung'u, T., Gounder, K., Chen, F., Riddell, L. & 11 others, , Dec 2012, In: Journal of Virology. 86, 23, p. 12643-12654 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
A Randomised, Placebo-Controlled, First-In-Human Study of a Novel Clade C Therapeutic Peptide Vaccine Administered Ex Vivo to Autologous White Blood Cells in HIV Infected Individuals
Jackson, Andrew D., Kløverpris, Henrik Nyhus, Boffito, M., Handley, A., Atkins, M., Hayes, P., Gilmour, J., Riddel, L., Chen, F., Bailey-Tippets, M., Walker, B., Ackland, J., Sullivan, M. & Goulder, P., 2013, In: PLoS ONE.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CD8αα expression marks terminally differentiated human CD8+ T cells expanded in chronic viral infection
Walker, L. J., Marrinan, E., Muenchhoff, M., Ferguson, J., Kløverpris, Henrik Nyhus, Cheroutre, H., Barnes, E., Goulder, P. & Klenerman, P., 2013, In: Frontiers in Immunology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T Cells
Kløverpris, Henrik Nyhus, Payne, R. P., Sacha, J. B., Rasaiyaah, J. T., Chen, F., Takiguchi, M., Yang, O. O., Towers, G. J., Goulder, P. & Prado, J. G., 2013, In: Journal of Virology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01
Kløverpris, Henrik Nyhus, Stryhn, A., Harndahl, M., Payne, R., Towers, G. J., Chen, F., Riddell, L., Walker, B. D., Ndung'u, T., Leslie, A., Buus, Søren & Goulder, P., 2013, In: Journal of Virology.Research output: Contribution to journal › Journal article › Research › peer-review
Nef-specific CD8+ T cell responses contribute to HIV-1 immune control
Adland, E., Carlson, J. M., Paioni, P., Kløverpris, Henrik Nyhus, Shapiro, R., Ogwu, A., Riddell, L., Luzzi, G., Chen, F., Balachandran, T., Heckerman, D., Stryhn, A., Edwards, A., Ndung'u, T., Walker, B. D., Buus, Søren, Goulder, P. & Matthews, P. C., 2013, In: PLoS ONE. 8, 9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Non-Immunogenicity of Overlapping Gag Peptides Pulsed on Autologous Cells after Vaccination of HIV Infected Individuals
Kløverpris, Henrik Nyhus, Jackson, Andrew D., Handley, A., Hayes, P., Gilmour, J., Riddell, L., Chen, F., Atkins, M., Boffito, M., Walker, B. D., Ackland, J., Sullivan, M. & Goulder, P., 2013, In: PLoS ONE.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HLA-A*68:02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective
Kløverpris, Henrik Nyhus, Buus, Anette Stryhn, Harndahl, M., Carlson, J. M., Leslie, A. J., Chen, F., Riddell, L., Mulenga, J., Walker, B. D., Ndung'u, T., Buus, Søren & Goulder, P., 17 Jul 2013, In: AIDS (London, England). 27, 11, p. 1717-23 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
Differential escape patterns within the dominant HLA-B*57:03-restricted HIV gag epitope reflect distinct clade-specific functional constraints
Payne, R. P., Branch, S., Kløverpris, H., Matthews, P. C., Koofhethile, C. K., Strong, T., Adland, E., Leitman, E., Frater, J., Ndung'u, T., Hunter, E., Haubrich, R., Mothe, B., Edwards, A., Riddell, L., Chen, F., Harrigan, P. R., Brumme, Z. L., Mallal, S., John, M. & 9 others, , 2014, In: Journal of Virology. 88, 9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HIV subtype influences HLA-B*07:02-associated HIV disease outcome
Kløverpris, Henrik Nyhus, Adland, E., Koyanagi, M., Buus, Anette Stryhn, Harndahl, M., Matthews, P. C., Shapiro, R., Walker, B. D., Ndung'u, T., Brander, C., Takiguchi, M., Buus, Søren & Goulder, P., May 2014, In: AIDS Research and Human Retroviruses. 30, 5, p. 468-75 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load
Kløverpris, Henrik Nyhus, McGregor, R., McLaren, J. E., Ladell, K., Buus, Anette Stryhn, Koofhethile, C., Brener, J., Chen, F., Riddell, L., Graziano, L., Klenerman, P., Leslie, A., Buus, Søren, Price, D. A. & Goulder, P., 10 Sep 2014, In: AIDS (London, England). 28, 14, p. 2007-21 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape
Kløverpris, Henrik Nyhus, Cole, D. K., Fuller, A., Carlson, J., Beck, K., Schauenburg, A. J., Rizkallah, P. J., Buus, Søren, Sewell, A. K. & Goulder, P., 20 Feb 2015, In: Retrovirology. 12, p. 1-11 11 p., 20.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human and Murine Clonal CD8+T Cell Expansions Arise during Tuberculosis Because of TCR Selection
Nunes-Alves, C., Booty, M. G., Carpenter, S. M., Rothchild, A. C., Martin, C. J., Desjardins, D., Steblenko, K., Kløverpris, Henrik Nyhus, Madansein, R., Ramsuran, D., Leslie, A., Correia-Neves, M. & Behar, S. M., May 2015, In: P L o S Pathogens. 11, 5, p. 1-29 29 p., e1004849.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CD8+ TCR Bias and Immunodominance in HIV-1 Infection
Kløverpris, Henrik Nyhus, McGregor, R., McLaren, J. E., Ladell, K., Harndahl, M., Buus, Anette Stryhn, Carlson, J. M., Koofhethile, C., Gerritsen, B., Kesmir, C., Chen, F., Riddell, L., Luzzi, G., Leslie, A., Walker, B. D., Ndung'u, T., Buus, Søren, Price, D. A. & Goulder, P. J., 1 Jun 2015, In: Journal of Immunology. 194, 11, p. 5329-5345 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point
Ndhlovu, Z. M., Kamya, P., Mewalal, N., Kloverpris, H. N., Nkosi, T., Pretorius, K., Laher, F., Ogunshola, F., Chopera, D., Shekhar, K., Ghebremichael, M., Ismail, N., Moodley, A., Malik, A., Leslie, A., Goulder, P. J. R., Buus, S., Chakraborty, A., Dong, K., Ndung'u, T. & 1 others, , 15 Sep 2015, In: Immunity. 43, 3, p. 591-604 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 43835678
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Role of HLA adaptation in HIV evolution
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Malnutrition in HIV-Infected Children Is an Indicator of Severe Disease with an Impaired Response to Antiretroviral Therapy
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Major TCR Repertoire Perturbation by Immunodominant HLA-B*44:03-Restricted CMV-Specific T Cells
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