Judith Margarete Gottwein
Associate Professor
Virology
Nørre Allé 14
2200 København N
- 2023
- Published
An inactivated SARS-CoV-2 vaccine induced cross-neutralizing persisting antibodies and protected against challenge in small animals
Offersgaard, Anna Falden, Duarte Hernandez, Carlos Rene, Feng, S., Marichal-Gallardo, P., Holmbeck, Kenn, Pihl, A. F., Fernandez-Antunez, C., Alzua, G. P., Hartmann, Katrine Top, Pham, Long, Zhou, Y., Gammeltoft, Karen Anbro, Fahnøe, Ulrik, Schneider, Uffe Vest, Pedersen, Gabriel Kristian, Jensen, Henrik Elvang, Christensen, Jan Pravsgaard, Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: iScience. 26, 2, 105949.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of multi-DAA resistance using a novel hepatitis C virus genotype 3a infectious culture system
Fernandez-Antunez, C., Wang, K., Fahnøe, Ulrik, Mikkelsen, L. S., Gottwein, Judith Margarete, Bukh, Jens & Ramirez Almeida, Santseharay, 2023, In: Hepatology. 78, 2, p. 621-636 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of Glycan Shift on Antibodies against Hepatitis C Virus E2 412–425 Epitope Elicited by Chimeric sHBsAg-Based Virus-Like Particles
Czarnota, A., Offersgaard, Anna Falden, Owsianka, A., Alzua, G. P., Bukh, Jens, Gottwein, Judith Margarete, Patel, A. H., Bienkowska-Szewczyk, K. & Grzyb, K., 2023, In: Microbiology Spectrum. 11, 2, 17 p., e0024523.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus RNA is 5'-capped with flavin adenine dinucleotide
Sherwood, A. V., Rivera-Rangel, L. R., Ryberg, L. A., Larsen, H. S., Anker, K. M., Costa, R., Vågbø, C. B., Jakljevič, E., Pham, L. V., Fernandez-Antunez, C., Indrisiunaite, G., Podolska-Charlery, A., Grothen, J. E. R., Langvad, N. W., Fossat, N., Offersgaard, A., Al-Chaer, A., Nielsen, L., Kuśnierczyk, A., Sølund, C. & 8 others, , 2023, In: Nature. 619, p. 811-818Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of novel neutralizing determinants for protection against HCV
Alzua, G. P., Pihl, A. F., Offersgaard, Anna Falden, Velázquez-Moctezuma, R., Duarte Hernandez, Carlos Rene, Augestad, Elias Honerød, Fahnøe, Ulrik, Mathiesen, C. K., Krarup, H., Law, M., Prentø, Jannick, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: Hepatology. 73, 3, p. 982-996Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inactivated genotype 1a, 2a and 3a HCV vaccine candidates induced broadly neutralising antibodies in mice
Alzua, G. P., Pihl, A. F., Offersgaard, Anna Falden, Duarte Hernandez, Carlos Rene, Duan, Z., Feng, S., Fahnøe, Ulrik, Sølund, C., Weis, Nina, Law, M., Prentø, Jannick, Christensen, Jan Pravsgaard, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: Gut. 72, 3, p. 560-572Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substitutions in SARS-CoV-2 Mpro Selected by Protease Inhibitor Boceprevir Confer Resistance to Nirmatrelvir
Gammeltoft, Karen Anbro, Zhou, Y., Ryberg, Line Abildgaard, Pham, Long, Binderup, A., Duarte Hernandez, Carlos Rene, Offersgaard, Anna Falden, Fahnøe, Ulrik, Peters, G. H. J., Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: Viruses. 15, 9, 17 p., 1970.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Toward a vaccine against hepatitis C virus
Offersgaard, Anna Falden, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: Science. 380, 6640, p. 37-38 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Establishment of high-titer HCV and SARS-CoV-2 production in a scalable packed-bed bioreactor for inactivated vaccines inducing neutralizing antibodies in animals
Offersgaard, A. F., Hernandez, C. R. D., Finne Pihl, A., Feng, S., Marichal-Gallardo, P., Venkatesan, N. P., Lin, X., Fernandez-Antunez, C., Pena Alzua, G., Costa, R., Hartmann, K. T., Pham, L., Zhou, Y., Gammeltoft, K. A., Fahnøe, U., Scheel, T. K. H., Schneider, U. V., Jensen, H. E., Christensen, J. P., Ramirez Almeida, S. & 4 others, , 6 Jul 2022.Research output: Contribution to conference › Poster › Communication
- Published
Establishment of high-titer HCV and SARS-CoV-2 production in a scalable packed-bed bioreactor for inactivated vaccines inducing neutralizing antibodies in animals
Offersgaard, A. F., Hernandez, C. R. D., Finne Pihl, A., Feng, S., Marichal-Gallardo, P., Holmbeck, K., Venkatesan, N. P., Lin, X., Fernandez-Antunez, C., Pena Alzua, G., Costa, R., Hartmann, K. T., Pham, L., Zhou, Y., Gammeltoft, K. A., Fahnøe, U., Scheel, T. K. H., Schneider, U. V., Jensen, H. E., Christensen, J. P. & 5 others, , 6 Jul 2022.Research output: Contribution to conference › Conference abstract for conference › Communication
- Published
High‐Titer Hepatitis C Virus Production in a Scalable Single‐Use High Cell Density Bioreactor
Offersgaard, Anna Falden, Duarte Hernandez, C. R., Finne Pihl, A., Prabhakar Venkatesan, N., Krarup, H., Lin, X., Reichl, U., Bukh, Jens, Genzel, Y. & Gottwein, Judith Margarete, 2022, In: Vaccines. 10, 2, 249.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inactivated whole hepatitis C virus vaccine employing a licensed adjuvant elicits cross-genotype neutralizing antibodies in mice
Pihl, A. F., Feng, S., Offersgaard, Anna Falden, Alzua, G. P., Augestad, Elias Honerød, Mathiesen, C. K., Jensen, T. B., Krarup, H., Law, M., Prentø, Jannick, Christensen, Jan Pravsgaard, Bukh, Jens & Gottwein, Judith Margarete, 2022, In: Journal of Hepatology. 76, 5, p. 1051-1061Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system
Zhou, Y., Gammeltoft, Karen Anbro, Ryberg, Line Abildgaard, Pham, Long, Tjørnelund, H. D., Binderup, A., Duarte Hernandez, Carlos Rene, Fernandez-Antunez, C., Offersgaard, Anna Falden, Fahnøe, Ulrik, Peters, G. H. J., Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2022, In: Science Advances. 8, 51, eadd7197.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Versatile SARS-CoV-2 Reverse-Genetics Systems for the Study of Antiviral Resistance and Replication
Fahnøe, Ulrik, Pham, Long, Fernandez-Antunez, C., Costa, Rui, Rivera, Lizandro, Galli, Andrea, Feng, S., Mikkelsen, L. S., Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay & Bukh, Jens, 2022, In: Viruses. 14, 2, 172.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens
Prentø, Jannick, Janitzek, C. M., Velázquez-Moctezuma, R., Goksøyr, L., Olsen, Rebecca Wendelboe, Fanalista, Margherita, Augestad, Elias Honerød, Thrane, Susan, Pihl, A. F., Gottwein, Judith Margarete, Sander, Adam F. & Bukh, Jens, 2021, In: PLoS ONE. 16, e0255336.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficacy of ion-channel inhibitors amantadine, memantine and rimantadine for the treatment of SARS-CoV-2 in vitro
Zhou, Y., Gammeltoft, Karen Anbro, Galli, Andrea, Offersgaard, Anna Falden, Fahnøe, Ulrik, Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2021, In: Viruses. 13, 10, 2082.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2 in Vitro
Gammeltoft, Karen Anbro, Zhou, Y., Duarte Hernandez, C. R., Galli, Andrea, Offersgaard, Anna Falden, Costa, Rui, Pham, Long, Fahnøe, Ulrik, Feng, S., Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 9, e02680-20.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vitro efficacy of artemisinin-based treatments against SARS-CoV-2
Zhou, Y., Gilmore, K., Ramirez Almeida, Santseharay, Settels, E., Gammeltoft, Karen Anbro, Pham, Long, Fahnøe, Ulrik, Feng, S., Offersgaard, Anna Falden, Trimpert, J., Bukh, Jens, Osterrieder, K., Gottwein, Judith Margarete & Seeberger, P. H., 2021, In: Scientific Reports. 11, 14571.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Overcoming culture restriction for SARS-CoV-2 in human cells facilitates the screening of compounds inhibiting viral replication
Ramirez Almeida, Santseharay, Fernandez-Antunez, C., Galli, Andrea, Underwood, Alexander Paul James, Pham, Long, Ryberg, Line Abildgaard, Feng, S., Pedersen, M. S., Mikkelsen, L. S., Belouzard, S., Dubuisson, J., Sølund, C., Weis, Nina, Gottwein, Judith Margarete, Fahnøe, Ulrik & Bukh, Jens, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 7, 20 p., e00097-21.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sars-cov-2 production in a scalable high cell density bioreactor
Offersgaard, Anna Falden, Hernandez, C. R. D., Pihl, A. F., Costa, Rui, Venkatesan, N. P., Lin, X., Pham, Long, Feng, S., Fahnøe, Ulrik, Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Reichl, U., Bukh, Jens, Genzel, Y. & Gottwein, Judith Margarete, 2021, In: Vaccines. 9, 7, 706.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Development of a downstream process for the production of an inactivated whole hepatitis C virus vaccine
Lothert, K., Offersgaard, A. F., Pihl, A. F., Mathiesen, C. K., Jensen, T. B., Alzua, G. P., Fahnøe, Ulrik, Bukh, Jens, Gottwein, Judith Margarete & Wolff, M. W., 2020, In: Scientific Reports. 10, 13 p., 16261.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient culture of SARS-CoV-2 in human hepatoma cells enhances viability of the virus in human lung cancer cell lines permitting the screening of antiviral compounds
Ramirez Almeida, Santseharay, Fernandez-Antunez, C., Pham, Long, Ryberg, Line Abildgaard, Feng, S., Pedersen, M. S., Mikkelsen, L. S., Belouzard, S., Dubuisson, J., Gottwein, Judith Margarete, Fahnøe, Ulrik & Bukh, Jens, 2020, bioRxiv.Research output: Working paper › Preprint › Research
- Published
Specific antibodies induced by immunization with hepatitis B virus-like particles carrying hepatitis C virus envelope glycoprotein 2 epitopes show differential neutralization efficiency
Czarnota, A., Offersgaard, A., Pihl, A. F., Prentø, Jannick, Bukh, Jens, Gottwein, Judith Margarete, Bieńkowska-Szewczyk, K. & Grzyb, K., 2020, In: Vaccines. 8, 2, 19 p., 294.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants
Jensen, S. B., Fahnøe, U., Pham, L. V., Serre, S. B. N., Tang, Q., Ghanem, L., Pedersen, M. S., Ramirez, S., Humes, D., Pihl, A. F., Filskov, J., Sølund, C. S., Dietz, J., Fourati, S., Pawlotsky, J. M., Sarrazin, C., Weis, N., Schønning, K., Krarup, H., Bukh, J. & 1 others, , 2019, In: Hepatology. 70, 3, p. 771-787 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape
Pham, Long, Jensen, S. B., Fahnøe, Ulrik, Pedersen, M. S., Tang, Q., Ghanem, L., Ramirez Almeida, Santseharay, Humes, D., Serre, S. B. N., Schønning, Kristian, Bukh, Jens & Gottwein, Judith Margarete, 2019, In: Journal of Hepatology. 70, 3, p. 388-397Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Efficacy of NS5A Inhibitors Against Hepatitis C Virus Genotypes 1–7 and Escape Variants
Gottwein, Judith Margarete, Pham, Long, Mikkelsen, L. S., Ghanem, L., Ramirez Almeida, Santseharay, Scheel, Troels Kasper Høyer, Carlsen, T. H. R. & Bukh, Jens, Apr 2018, In: Gastroenterology. 154, 5, p. 1435-1448 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model
Galli, Andrea, Mens, H., Gottwein, Judith Margarete, Gerstoft, Jan & Bukh, Jens, 2018, In: Scientific Reports. 8, 1, 13 p., 4619.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HCV Genotype 6a Escape from and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models
Pham, Long, Ramirez Almeida, Santseharay, Gottwein, Judith Margarete, Fahnøe, Ulrik, Li, Y., Pedersen, J. & Bukh, Jens, 2018, In: Gastroenterology. 154, 8, p. 2194-2208.e12Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals
Pihl, A. F., Offersgaard, A. F., Mathiesen, C. K., Prentø, Jannick, Fahnøe, Ulrik, Krarup, H., Bukh, Jens & Gottwein, Judith Margarete, 2018, In: Scientific Reports. 8, 1, 13 p., 17505.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recombinant hepatitis C virus genotype 5a infectious cell culture systems expressing minimal JFH1 NS5B sequences permit polymerase inhibitor studies
Humes, D., Ramirez Almeida, Santseharay, Jensen, T. B., Li, Y. P., Gottwein, Judith Margarete & Bukh, Jens, 2018, In: Virology. 522, p. 177-192 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Efficient hepatitis c virus genotype 1b core-NS5A recombinants permit efficacy testing of protease and NS5A inhibitors
Pham, Long, Ramirez Almeida, Santseharay, Carlsen, T. H. R., Li, Y., Gottwein, Judith Margarete & Bukh, Jens, 2017, In: Antimicrobial Agents and Chemotherapy. 61, 6, 19 p., e00037-17.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir
Ramirez Almeida, Santseharay, Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Nov 2016, In: Gastroenterology. 151, 5, p. 973-985.e2Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.
Serre, S., Jensen, S., Ghanem, L., Humes, D., Ramirez, S., Li, Y., Krarup, H., Bukh, Jens & Gottwein, Judith Margarete, Jun 2016, In: Antimicrobial Agents and Chemotherapy. 60, 6, p. 3563-3578 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor Resistance
Jensen, S. B., Serre, S. B. N., Humes, D. G., Ramirez Almeida, Santseharay, Li, Y., Bukh, Jens & Gottwein, Judith Margarete, Dec 2015, In: Antimicrobial Agents and Chemotherapy. 59, 12, p. 7426-7436 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant
Mathiesen, C. K., Prentø, Jannick, Meredith, L. W., Jensen, T. B., Krarup, H., McKeating, J. A., Gottwein, Judith Margarete & Bukh, Jens, Aug 2015, In: Journal of Virology. 89, 15, p. 7758-7775 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell culture system of a hepatitis C genotype 3a and 2a chimera: Patent #: 8,945,584
Gottwein, Judith Margarete, Scheel, T. K. H., Eugen-Olsen, J. & Bukh, Jens, 3 Feb 2015, IPC No. A61K 39/29 (20060101); C12N 15/06 (20060101); C12Q 1/02 (20060101); C07H 21/00 (20060101); C12N 7/02 (20060101); A61K 39/12 (20060101), Patent No. WO2008/125117, 23 Oct 2008, Priority date 11 Apr 2008, Priority No. PCT/DK2008/050083Research output: Patent
- Published
Infectious hepatitis C viruses of genotype 3A and 4A and uses thereof: Patent #: 8,946,398
Gottwein, Judith Margarete, Scheel, T. K. H., Purcell, R. E. & Bukh, Jens, 3 Feb 2015, IPC No. C07H 21/04 (20060101); C07H 21/02 (20060101), Patent No. WO2011/038737, 26 Jul 2012, Priority date 16 Sep 2010, Priority No. PCT/DK2010/050236Research output: Patent
- Published
High Reproducibility of ELISPOT Counts from Nine Different Laboratories.
Sundararaman, S., Karulin, A., Ansari, T., BenHamouda, N., Gottwein, Judith Margarete, Laxmanan, S., Levine, S., Loffredo, J., McArdle, S., Neudoerfl, C., Roen, D., Silina, K., Welch, M. & Lehmann, P., 2015, In: Cells.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Infectious genotype 1a, 1b, 2a, 2b, 3a, 5a, 6a and 7a hepatitis C virus lacking the hypervariable region 1 (HVR1): Patent #: 8,846,891
Prentø, Jannick, Gottwein, Judith Margarete, Scheel, T. K. H., Bukh, Jens & Jensen, T. B., 30 Sep 2014, IPC No. C07H 21/04 (20060101); C07H 21/02 (20060101), Patent No. WO2010/022727, 4 Mar 2010, Priority date 7 Aug 2009, Priority No. PCT/DK2009/050197Research output: Patent
- Published
Hepatitis C virus expressing reporter tagged NS5A protein: Patent #: 8,772,022
Gottwein, Judith Margarete, Scheel, T. K. H., Bukh, Jens, Prentø, Jannick & Jensen, T. B., 8 Jul 2014, IPC No. C12N 15/00 (20060101); C12N 5/00 (20060101); C12N 7/00 (20060101); C12N 15/64 (20060101); A61K 39/29 (20060101); C12N 7/01 (20060101), Patent No. WO2010/037403, 8 Apr 2010, Priority date 5 Oct 2009, Priority No. PCT/DK2009/050263Research output: Patent
- Published
Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6
Mathiesen, C. K., Jensen, T. B., Prentø, Jannick, Krarup, H., Nicosia, A., Law, M., Bukh, Jens & Gottwein, Judith Margarete, Jun 2014, In: Virology. 458-459, p. 190-208 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient cell culture system for hepatitis C virus genotype 2B: Patent #: 8,663,653
Gottwein, Judith Margarete, Knudsen, M. L., Scheel, T. K. H. & Bukh, Jens, 31 Mar 2014, IPC No. A61K 39/12 (20060101); A61K 39/29 (20060101); C12N 1/20 (20060101); C12N 5/071 (20100101); C12N 15/00 (20060101); C12Q 1/70 (20060101), Patent No. WO2010/017818, 18 Feb 2010, Priority date 24 Jul 2009, Priority No. PCT/DK2009/050189Research output: Patent
- Published
Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors
Li, Y., Ramirez, S., Humes, D., Jensen, S. B., Gottwein, Judith Margarete & Bukh, Jens, Mar 2014, In: Gastroenterology. 146, 3, p. 812-821.e4 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors
Ramirez, S., Li, Y., Jensen, S. B., Pedersen, J., Gottwein, Judith Margarete & Bukh, Jens, Feb 2014, In: Hepatology. 59, 2, p. 395-407 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Log-Normal ELISPOT spot size distribution permits count harmonization among different laboratories.
Sundararaman, S., Karulin, A., BenHamouda, N., Gottwein, Judith Margarete, Laxmanan, S., Levine, S., Loffredo, J., McArdle, S., Neudoerfl, C., Roen, D., Silina, K., Welch, M. & Lehmann, P., 2014, In: Journal for ImmunoTherapy of Cancer.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Efficient cell culture system for hepatitis C virus genotype 5A: Patent #: 8,618,275
Jensen, T. B., Gottwein, Judith Margarete, Scheel, T. K. H., Eugen-Olsen, J. & Bukh, Jens, 31 Dec 2013, IPC No. C07H 21/00 (20060101); C12N 7/00 (20060101); A61K 39/295 (20060101); A61K 39/12 (20060101); A61K 39/29 (20060101), Patent No. WO2008/141651, 27 Nov 2008, Priority date 19 May 2008, Priority No. PCT/DK2008/050113Research output: Patent
- Published
Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor
Gottwein, Judith Margarete, Jensen, S. B., Serre, S. B. N., Ghanem, L., Scheel, Troels Kasper Høyer, Jensen, T. B., Krarup, H., Uzcategui, N., Mikkelsen, L. S. & Bukh, Jens, Dec 2013, In: Antimicrobial Agents and Chemotherapy. 57, 12, p. 6034-49 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of alpha interferon-induced envelope mutations of hepatitis C virus in vitro associated with increased viral fitness and interferon resistance
Serre, S. B. N., Krarup, H. B., Bukh, Jens & Gottwein, Judith Margarete, Dec 2013, In: Journal of Virology. 87, 23, p. 12776-93 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient cell culture system for hepatitis C virus genotype 6A: Patent #: 8,569,472
Gottwein, Judith Margarete, Scheel, T. K. H., Jensen, T. B. & Bukh, Jens, 29 Oct 2013, IPC No. C07H 21/00 (20060101); C12N 7/00 (20060101); A61K 39/295 (20060101); A61K 39/12 (20060101); A61K 39/29 (20060101), Patent No. WO2009/080052, 2 Jul 2009, Priority date 19 Dec 2008, Priority No. PCT/DK2008/050332Research output: Patent
- Published
Efficient cell culture system for hepatitis C virus genotype 1a and 1b: Patent #: 8,563,706
Scheel, T. K. H., Gottwein, Judith Margarete, Prentø, Jannick, Jensen, T. B. & Bukh, Jens, 22 Oct 2013, IPC No. C07H 21/00 (20060101); A61K 39/29 (20060101); A61K 39/12 (20060101); A61K 39/295 (20060101); C12N 7/00 (20060101), Patent No. WO2009/080053, 2 Jul 2009, Priority date 19 Dec 2008, Priority No. PCT/DK2008/050333Research output: Patent
ID: 40928930
Most downloads
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177
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High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
170
downloads
Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
136
downloads
Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model
Research output: Contribution to journal › Journal article › Research › peer-review
Published