Judith Margarete Gottwein

Judith Margarete Gottwein

Associate Professor

ORCID: 0000-0003-2805-0256

Publication year:
All
26 - 50 out of 70Page size: 25
  1. 2018
  2. Published

    Efficacy of NS5A Inhibitors Against Hepatitis C Virus Genotypes 1–7 and Escape Variants

    Gottwein, Judith Margarete, Pham, Long, Mikkelsen, L. S., Ghanem, L., Ramirez Almeida, Santseharay, Scheel, Troels Kasper Høyer, Carlsen, T. H. R. & Bukh, Jens, Apr 2018, In: Gastroenterology. 154, 5, p. 1435-1448 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model

    Galli, Andrea, Mens, H., Gottwein, Judith Margarete, Gerstoft, Jan & Bukh, Jens, 2018, In: Scientific Reports. 8, 1, 13 p., 4619.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    HCV Genotype 6a Escape from and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models

    Pham, Long, Ramirez Almeida, Santseharay, Gottwein, Judith Margarete, Fahnøe, Ulrik, Li, Y., Pedersen, J. & Bukh, Jens, 2018, In: Gastroenterology. 154, 8, p. 2194-2208.e12

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals

    Pihl, A. F., Offersgaard, A. F., Mathiesen, C. K., Prentø, Jannick, Fahnøe, Ulrik, Krarup, H., Bukh, Jens & Gottwein, Judith Margarete, 2018, In: Scientific Reports. 8, 1, 13 p., 17505.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Recombinant hepatitis C virus genotype 5a infectious cell culture systems expressing minimal JFH1 NS5B sequences permit polymerase inhibitor studies

    Humes, D., Ramirez Almeida, Santseharay, Jensen, T. B., Li, Y. P., Gottwein, Judith Margarete & Bukh, Jens, 2018, In: Virology. 522, p. 177-192 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. 2017
  8. Published

    Efficient hepatitis c virus genotype 1b core-NS5A recombinants permit efficacy testing of protease and NS5A inhibitors

    Pham, Long, Ramirez Almeida, Santseharay, Carlsen, T. H. R., Li, Y., Gottwein, Judith Margarete & Bukh, Jens, 2017, In: Antimicrobial Agents and Chemotherapy. 61, 6, 19 p., e00037-17.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 2016
  10. Published

    Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir

    Ramirez Almeida, Santseharay, Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Nov 2016, In: Gastroenterology. 151, 5, p. 973-985.e2

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.

    Serre, S., Jensen, S., Ghanem, L., Humes, D., Ramirez, S., Li, Y., Krarup, H., Bukh, Jens & Gottwein, Judith Margarete, Jun 2016, In: Antimicrobial Agents and Chemotherapy. 60, 6, p. 3563-3578 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 2015
  13. Published

    Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor Resistance

    Jensen, S. B., Serre, S. B. N., Humes, D. G., Ramirez Almeida, Santseharay, Li, Y., Bukh, Jens & Gottwein, Judith Margarete, Dec 2015, In: Antimicrobial Agents and Chemotherapy. 59, 12, p. 7426-7436 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant

    Mathiesen, C. K., Prentø, Jannick, Meredith, L. W., Jensen, T. B., Krarup, H., McKeating, J. A., Gottwein, Judith Margarete & Bukh, Jens, Aug 2015, In: Journal of Virology. 89, 15, p. 7758-7775 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Cell culture system of a hepatitis C genotype 3a and 2a chimera: Patent #: 8,945,584

    Gottwein, Judith Margarete, Scheel, T. K. H., Eugen-Olsen, J. & Bukh, Jens, 3 Feb 2015, IPC No. A61K 39/29 (20060101); C12N 15/06 (20060101); C12Q 1/02 (20060101); C07H 21/00 (20060101); C12N 7/02 (20060101); A61K 39/12 (20060101), Patent No. WO2008/125117, 23 Oct 2008, Priority date 11 Apr 2008, Priority No. PCT/DK2008/050083

    Research output: Patent

  16. Published

    Infectious hepatitis C viruses of genotype 3A and 4A and uses thereof: Patent #: 8,946,398

    Gottwein, Judith Margarete, Scheel, T. K. H., Purcell, R. E. & Bukh, Jens, 3 Feb 2015, IPC No. C07H 21/04 (20060101); C07H 21/02 (20060101), Patent No. WO2011/038737, 26 Jul 2012, Priority date 16 Sep 2010, Priority No. PCT/DK2010/050236

    Research output: Patent

  17. Published

    High Reproducibility of ELISPOT Counts from Nine Different Laboratories.

    Sundararaman, S., Karulin, A., Ansari, T., BenHamouda, N., Gottwein, Judith Margarete, Laxmanan, S., Levine, S., Loffredo, J., McArdle, S., Neudoerfl, C., Roen, D., Silina, K., Welch, M. & Lehmann, P., 2015, In: Cells.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. 2014
  19. Published

    Infectious genotype 1a, 1b, 2a, 2b, 3a, 5a, 6a and 7a hepatitis C virus lacking the hypervariable region 1 (HVR1): Patent #: 8,846,891

    Prentø, Jannick, Gottwein, Judith Margarete, Scheel, T. K. H., Bukh, Jens & Jensen, T. B., 30 Sep 2014, IPC No. C07H 21/04 (20060101); C07H 21/02 (20060101), Patent No. WO2010/022727, 4 Mar 2010, Priority date 7 Aug 2009, Priority No. PCT/DK2009/050197

    Research output: Patent

  20. Published

    Hepatitis C virus expressing reporter tagged NS5A protein: Patent #: 8,772,022

    Gottwein, Judith Margarete, Scheel, T. K. H., Bukh, Jens, Prentø, Jannick & Jensen, T. B., 8 Jul 2014, IPC No. C12N 15/00 (20060101); C12N 5/00 (20060101); C12N 7/00 (20060101); C12N 15/64 (20060101); A61K 39/29 (20060101); C12N 7/01 (20060101), Patent No. WO2010/037403, 8 Apr 2010, Priority date 5 Oct 2009, Priority No. PCT/DK2009/050263

    Research output: Patent

  21. Published

    Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6

    Mathiesen, C. K., Jensen, T. B., Prentø, Jannick, Krarup, H., Nicosia, A., Law, M., Bukh, Jens & Gottwein, Judith Margarete, Jun 2014, In: Virology. 458-459, p. 190-208 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Efficient cell culture system for hepatitis C virus genotype 2B: Patent #: 8,663,653

    Gottwein, Judith Margarete, Knudsen, M. L., Scheel, T. K. H. & Bukh, Jens, 31 Mar 2014, IPC No. A61K 39/12 (20060101); A61K 39/29 (20060101); C12N 1/20 (20060101); C12N 5/071 (20100101); C12N 15/00 (20060101); C12Q 1/70 (20060101), Patent No. WO2010/017818, 18 Feb 2010, Priority date 24 Jul 2009, Priority No. PCT/DK2009/050189

    Research output: Patent

  23. Published

    Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors

    Li, Y., Ramirez, S., Humes, D., Jensen, S. B., Gottwein, Judith Margarete & Bukh, Jens, Mar 2014, In: Gastroenterology. 146, 3, p. 812-821.e4 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors

    Ramirez, S., Li, Y., Jensen, S. B., Pedersen, J., Gottwein, Judith Margarete & Bukh, Jens, Feb 2014, In: Hepatology. 59, 2, p. 395-407 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Log-Normal ELISPOT spot size distribution permits count harmonization among different laboratories.

    Sundararaman, S., Karulin, A., BenHamouda, N., Gottwein, Judith Margarete, Laxmanan, S., Levine, S., Loffredo, J., McArdle, S., Neudoerfl, C., Roen, D., Silina, K., Welch, M. & Lehmann, P., 2014, In: Journal for ImmunoTherapy of Cancer.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. 2013
  27. Published

    Efficient cell culture system for hepatitis C virus genotype 5A: Patent #: 8,618,275

    Jensen, T. B., Gottwein, Judith Margarete, Scheel, T. K. H., Eugen-Olsen, J. & Bukh, Jens, 31 Dec 2013, IPC No. C07H 21/00 (20060101); C12N 7/00 (20060101); A61K 39/295 (20060101); A61K 39/12 (20060101); A61K 39/29 (20060101), Patent No. WO2008/141651, 27 Nov 2008, Priority date 19 May 2008, Priority No. PCT/DK2008/050113

    Research output: Patent

  28. Published

    Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor

    Gottwein, Judith Margarete, Jensen, S. B., Serre, S. B. N., Ghanem, L., Scheel, Troels Kasper Høyer, Jensen, T. B., Krarup, H., Uzcategui, N., Mikkelsen, L. S. & Bukh, Jens, Dec 2013, In: Antimicrobial Agents and Chemotherapy. 57, 12, p. 6034-49 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Identification of alpha interferon-induced envelope mutations of hepatitis C virus in vitro associated with increased viral fitness and interferon resistance

    Serre, S. B. N., Krarup, H. B., Bukh, Jens & Gottwein, Judith Margarete, Dec 2013, In: Journal of Virology. 87, 23, p. 12776-93 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Efficient cell culture system for hepatitis C virus genotype 6A: Patent #: 8,569,472

    Gottwein, Judith Margarete, Scheel, T. K. H., Jensen, T. B. & Bukh, Jens, 29 Oct 2013, IPC No. C07H 21/00 (20060101); C12N 7/00 (20060101); A61K 39/295 (20060101); A61K 39/12 (20060101); A61K 39/29 (20060101), Patent No. WO2009/080052, 2 Jul 2009, Priority date 19 Dec 2008, Priority No. PCT/DK2008/050332

    Research output: Patent

  31. Published

    Efficient cell culture system for hepatitis C virus genotype 1a and 1b: Patent #: 8,563,706

    Scheel, T. K. H., Gottwein, Judith Margarete, Prentø, Jannick, Jensen, T. B. & Bukh, Jens, 22 Oct 2013, IPC No. C07H 21/00 (20060101); A61K 39/29 (20060101); A61K 39/12 (20060101); A61K 39/295 (20060101); C12N 7/00 (20060101), Patent No. WO2009/080053, 2 Jul 2009, Priority date 19 Dec 2008, Priority No. PCT/DK2008/050333

    Research output: Patent

Previous 1 2 3 Next

ID: 40928930