Judith Margarete Gottwein

Judith Margarete Gottwein

Associate Professor

ORCID: 0000-0003-2805-0256

Publication year:
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1 - 25 out of 70Page size: 25
  1. 2001
  2. Published

    Protective anti-helicobacter immunity is induced with aluminum hydroxide or complete Freund's adjuvant by systemic immunization

    Gottwein, Judith Margarete, Blanchard, T. G., Targoni, O. S., Eisenberg, J. C., Zagorski, B. M., Redline, R. W., Nedrud, J. G., Tary-Lehmann, M., Lehmann, P. V. & Czinn, S. J., 1 Aug 2001, In: Journal of Infectious Diseases. 184, 3, p. 308-314 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2003
  4. Published

    Protective efficacy of anti-Helicobacter pylori immunity following systemic immunization of neonatal mice

    Eisenberg, J. C., Czinn, S. J., Garhart, C. A., Redline, R. W., Bartholomae, W. C., Gottwein, Judith Margarete, Nedrud, J. G., Emancipator, S. E., Boehm, B. B., Lehmann, P. V. & Blanchard, T. G., 1 Apr 2003, In: Infection and Immunity. 71, 4, p. 1820-1827 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 2008
  6. Published

    Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems.

    Gottwein, Judith Margarete & Bukh, Jens, 2008, In: Advances in Virus Research. 71, p. 51-133 82 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization

    Scheel, Troels Kasper Høyer, Gottwein, Judith Margarete, Jensen, T. B., Prentø, Jannick, Høegh, A. M., Alter, H. J., Eugen-Olsen, J. & Bukh, Jens, 2008, In: Proceedings of the National Academy of Science of the United States of America. 105, 3, p. 997-1002 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Highly Efficient JFH1-Based Cell-Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing-Antibody Treatment to Control Infection

    Jensen, T. B., Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Høgh, A. M., Eugen-Olsen, J. & Bukh, Jens, 2008, In: Journal of Infectious Diseases. 198, 12, p. 1756-1765 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 2009
  10. Published

    DELETION OF HYPERVARIABLE REGION 1 (HVR1) OF E2 FROM HCV GENOTYPES 1-6 HAS DIFFERENTIAL EFFECT ON INFECTIVITY IN VITRO AND CAUSES INCREASED SUSCEPTIBILITY TO NEUTRALIZATION

    Prentø, Jannick, Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Jensen, T. B., Serre, S. & Bukh, Jens, 2009, In: Journal of Hepatology. 50, p. S34-S34

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs

    Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Jensen, T. B., Lademann, J. B., Prentø, Jannick, Knudsen, M. L., Hoegh, A. M. & Bukh, Jens, 2009, In: Hepatology. 49, 2, p. 364-77 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    MONOCISTRONIC HEPATITIS C REPORTER VIRUS RECOMBINANTS OF ALL MAJOR GENOTYPES EXPRESSING ENHANCED GREEN FLUORESCENT PROTEIN TAGGED NS5A PROTEIN

    Gottwein, Judith Margarete, Lademann, J. B., Scheel, Troels Kasper Høyer, Jensen, T. B., Prentø, Jannick & Bukh, Jens, 2009, In: Journal of Hepatology. 50, p. S33-S33

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. 2010
  14. Published

    Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies

    Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Callendret, B., Li, Y., Eccleston, H. B., Engle, R. E., Govindarajan, S., Satterfield, W., Purcell, R. H., Walker, C. M. & Bukh, Jens, 2010, In: Journal of Virology. 84, 10, p. 5277-93 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. 2012
  16. Published

    Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems

    Scheel, Troels Kasper Høyer, Prentø, Jannick, Carlsen, T. H. R., Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, 2012, In: P L o S Pathogens. 8, 5, p. 1-16 17 p., e1002696.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains

    Li, Y., Ramirez, S., Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Mikkelsen, L., Purcell, R. H. & Bukh, Jens, 2012, In: Proceedings of the National Academy of Sciences USA (PNAS). 109, 18, p. E1101-E1110 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells

    Saeed, M., Scheel, Troels Kasper Høyer, Gottwein, Judith Margarete, Marukian, S., Dustin, L. B., Bukh, Jens & Rice, C. M., Oct 2012, In: Antimicrobial Agents and Chemotherapy. 56, 10, p. 5365-73 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system

    Li, Y., Ramirez, S., Jensen, S. B., Purcell, R. H., Gottwein, Judith Margarete & Bukh, Jens, 27 Nov 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 48, p. 19757-62 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. 2013
  21. Published

    Neutralization resistance of hepatitis C virus can be overcome by recombinant human monoclonal antibodies

    Pedersen, J. L., Carlsen, T. H. R., Prentø, Jannick, Ramirez, S., Jensen, T. B., Forns, X., Alter, H., Foung, S. K. H., Law, M., Gottwein, Judith Margarete, Weis, Nina & Bukh, Jens, 2013, In: Hepatology. 58, 5, p. 1587-1597 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses

    Gottwein, Judith Margarete, Jensen, S. B., Li, Y., Ghanem, L., Scheel, Troels Kasper Høyer, Serre, S. B. N., Mikkelsen, L. & Bukh, Jens, Mar 2013, In: Antimicrobial Agents and Chemotherapy. 57, 3, p. 1291-303 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Productive homologous and non-homologous recombination of hepatitis C virus in cell culture

    Scheel, Troels Kasper Høyer, Galli, A., Li, Y., Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Mar 2013, In: P L o S Pathogens. 9, 3, p. 1-12 13 p., e1003228.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Adaptive mutations allow establishment of JFH1-based cell culture systems for hepatitis C virus genotype 4A: Patent #: 8,454,974

    Scheel, T. K. H., Gottwein, Judith Margarete, Eugen-Olsen, J. & Bukh, Jens, 4 Jun 2013, IPC No. A61K 39/29 (20060101); C07H 21/00 (20060101); C12N 15/06 (20060101); C12N 7/02 (20060101); C12Q 1/02 (20060101), Patent No. WO2008/125119, 23 Oct 2008, Priority date 11 Apr 2008, Priority No. PCT/DK2008/050085

    Research output: Patent

  25. Published

    Efficient cell culture system for hepatitis C virus genotype 7a: Patent #: 8,506,969

    Gottwein, Judith Margarete, Scheel, T. K. H., Jensen, T. B. & Bukh, Jens, 13 Aug 2013, IPC No. A61K 39/12 (20060101); A61K 39/29 (20060101); C12Q 1/70 (20060101); C12N 15/00 (20060101); C12N 5/071 (20100101); C12N 1/20 (20060101), Patent No. WO2010/017819, 18 Feb 2010, Priority date 31 Jul 2009, Priority No. PCT/DK2009/050193

    Research output: Patent

  26. Published

    Viral hepatitis: Cell-culture-derived HCV--a promising vaccine antigen

    Gottwein, Judith Margarete & Bukh, Jens, Sep 2013, In: Nature Reviews. Gastroenterology & Hepatology. 10, 9, p. 508-9 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Analysis of hepatitis C virus core/NS5A protein co-localization using novel cell culture systems expressing core-NS2 and NS5A of genotypes 1-7

    Galli, A., Scheel, Troels Kasper Høyer, Prentø, Jannick, Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Oct 2013, In: The Journal of general virology. 94, Pt 10, p. 2221-35 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Efficient cell culture system for hepatitis C virus genotype 1a and 1b: Patent #: 8,563,706

    Scheel, T. K. H., Gottwein, Judith Margarete, Prentø, Jannick, Jensen, T. B. & Bukh, Jens, 22 Oct 2013, IPC No. C07H 21/00 (20060101); A61K 39/29 (20060101); A61K 39/12 (20060101); A61K 39/295 (20060101); C12N 7/00 (20060101), Patent No. WO2009/080053, 2 Jul 2009, Priority date 19 Dec 2008, Priority No. PCT/DK2008/050333

    Research output: Patent

  29. Published

    Efficient cell culture system for hepatitis C virus genotype 6A: Patent #: 8,569,472

    Gottwein, Judith Margarete, Scheel, T. K. H., Jensen, T. B. & Bukh, Jens, 29 Oct 2013, IPC No. C07H 21/00 (20060101); C12N 7/00 (20060101); A61K 39/295 (20060101); A61K 39/12 (20060101); A61K 39/29 (20060101), Patent No. WO2009/080052, 2 Jul 2009, Priority date 19 Dec 2008, Priority No. PCT/DK2008/050332

    Research output: Patent

  30. Published

    Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor

    Gottwein, Judith Margarete, Jensen, S. B., Serre, S. B. N., Ghanem, L., Scheel, Troels Kasper Høyer, Jensen, T. B., Krarup, H., Uzcategui, N., Mikkelsen, L. S. & Bukh, Jens, Dec 2013, In: Antimicrobial Agents and Chemotherapy. 57, 12, p. 6034-49 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Identification of alpha interferon-induced envelope mutations of hepatitis C virus in vitro associated with increased viral fitness and interferon resistance

    Serre, S. B. N., Krarup, H. B., Bukh, Jens & Gottwein, Judith Margarete, Dec 2013, In: Journal of Virology. 87, 23, p. 12776-93 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Efficient cell culture system for hepatitis C virus genotype 5A: Patent #: 8,618,275

    Jensen, T. B., Gottwein, Judith Margarete, Scheel, T. K. H., Eugen-Olsen, J. & Bukh, Jens, 31 Dec 2013, IPC No. C07H 21/00 (20060101); C12N 7/00 (20060101); A61K 39/295 (20060101); A61K 39/12 (20060101); A61K 39/29 (20060101), Patent No. WO2008/141651, 27 Nov 2008, Priority date 19 May 2008, Priority No. PCT/DK2008/050113

    Research output: Patent

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