Kenn Holmbeck
Associate Professor
Virology
Nørre Allé 14
2200 København N
- 2023
- Published
An inactivated SARS-CoV-2 vaccine induced cross-neutralizing persisting antibodies and protected against challenge in small animals
Offersgaard, Anna Falden, Duarte Hernandez, Carlos Rene, Feng, S., Marichal-Gallardo, P., Holmbeck, Kenn, Pihl, A. F., Fernandez-Antunez, C., Alzua, G. P., Hartmann, Katrine Top, Pham, Long, Zhou, Y., Gammeltoft, Karen Anbro, Fahnøe, Ulrik, Schneider, Uffe Vest, Pedersen, Gabriel Kristian, Jensen, Henrik Elvang, Christensen, Jan Pravsgaard, Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: iScience. 26, 2, 105949.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Full-length sequence analysis of hepatitis C virus genotype 3b strains and development of an in vivo infectious 3b cDNA clone
Bajpai, P. S., Collignon, Laura Maria F, Sølund, C., Madsen, L. W., Christensen, P. B., Øvrehus, A., Weis, Nina, Holmbeck, Kenn, Fahnøe, Ulrik & Bukh, Jens, 2023, In: Journal of Virology. 97, 12, 23 p., 00925.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus RNA is 5'-capped with flavin adenine dinucleotide
Sherwood, A. V., Rivera-Rangel, L. R., Ryberg, L. A., Larsen, H. S., Anker, K. M., Costa, R., Vågbø, C. B., Jakljevič, E., Pham, L. V., Fernandez-Antunez, C., Indrisiunaite, G., Podolska-Charlery, A., Grothen, J. E. R., Langvad, N. W., Fossat, N., Offersgaard, A., Al-Chaer, A., Nielsen, L., Kuśnierczyk, A., Sølund, C. & 8 others, , 2023, In: Nature. 619, p. 811-818Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular Determinants of Mouse Adaptation of Rat Hepacivirus
Wolfisberg, R., Holmbeck, Kenn, Billerbeck, E., Thorselius, Caroline Eva, Batista, M. N., Fahnøe, Ulrik, Lundsgaard, Emma Alberte, Kennedy, Matthew James, Nielsen, L., Rice, C. M., Bukh, Jens & Scheel, Troels Kasper Høyer, 2023, In: Journal of Virology. 97, 4, 17 p., e0181222.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Establishment of high-titer HCV and SARS-CoV-2 production in a scalable packed-bed bioreactor for inactivated vaccines inducing neutralizing antibodies in animals
Offersgaard, A. F., Hernandez, C. R. D., Finne Pihl, A., Feng, S., Marichal-Gallardo, P., Holmbeck, K., Venkatesan, N. P., Lin, X., Fernandez-Antunez, C., Pena Alzua, G., Costa, R., Hartmann, K. T., Pham, L., Zhou, Y., Gammeltoft, K. A., Fahnøe, U., Scheel, T. K. H., Schneider, U. V., Jensen, H. E., Christensen, J. P. & 5 others, , 6 Jul 2022.Research output: Contribution to conference › Conference abstract for conference › Communication
- Published
Neutralization and receptor use of infectious culture–derived rat hepacivirus as a model for HCV
Wolfisberg, R., Thorselius, Caroline Eva, Salinas, E., Elrod, E., Trivedi, S., Nielsen, L., Fahnøe, Ulrik, Kapoor, A., Grakoui, A., Rice, C. M., Bukh, Jens, Holmbeck, Kenn & Scheel, Troels Kasper Høyer, 2022, In: Hepatology. 76, 5, p. 1506-1519Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel HCV Genotype 4d Infectious Systems and Assessment of Direct-Acting Antivirals and Antibody Neutralization
Pham, Long, Velázquez-Moctezuma, R., Fahnøe, Ulrik, Collignon, Laura Maria F, Bajpai, P., Sølund, C., Weis, Nina, Holmbeck, Kenn, Prentø, Jannick & Bukh, Jens, 2022, In: Viruses. 14, 11, 2527.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Replicons of a Rodent Hepatitis C Model Virus Permit Selection of Highly Permissive Cells
Wolfisberg, R., Holmbeck, Kenn, Nielsen, L., Kapoor, A., Rice, C. M., Bukh, Jens & Scheel, Troels Kasper Høyer, 2019, In: Journal of Virology. 93, 19, 19 p., e00733-19.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding
Sanz, R. L., Ferraro, G. B., Kacervosky, J., Salesse, C., Gowing, E., Hua, L., Rambaldi, I., Beaubien, F., Holmbeck, Kenn, Cloutier, J. F., Lévesque, M., Murai, K. & Fournier, A. E., 2018, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 38, 3, p. 518-529 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
Btbd7 is essential for region-specific epithelial cell dynamics and branching morphogenesis in vivo
Daley, W. P., Matsumoto, K., Doyle, A. D., Wang, S., DuChez, B. J., Holmbeck, Kenn & Yamada, K. M., 2017, In: Development (Cambridge). 144, 12, p. 2200-2211 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Vasopressin stimulates the proliferation and differentiation of red blood cell precursors and improves recovery from anemia
Mayer, B., Németh, K., Krepuska, M., Myneni, V. D., Maric, D., Tisdale, J. F., Hsieh, M. M., Uchida, N., Lee, H-J., Nemeth, M. J., Holmbeck, K., Noguchi, C. T., Rogers, H., Dey, S., Hansen, A., Hong, J., Chow, I., Key, S., Szalayova, I., Pagani, J. & 6 others, , 2017, In: Science Translational Medicine. 9, 418Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream
Langenfurth, A., Gu, S., Bautze, V., Zhang, C., Neumann, J. E., Schüller, U., Stock, K., Wolf, S. A., Maier, A., Mastrella, G., Pak, A., Cheng, H., Kälin, R. E., Holmbeck, Kenn, Strotmann, J., Kettenmann, H. & Glass, R., 30 Aug 2016, In: Scientific Reports. 6, 32203.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo
Motley, M. P., Madsen, Daniel Hargbøl, Jürgensen, Henrik Jessen, Spencer, D. E., Szabo, R., Holmbeck, Kenn, Flick, M. J., Lawrence, D. A., Castellino, F. J., Weigert, R. & Bugge, T. H., 2016, In: Blood. 127, 9, p. 1085-1096 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multiple essential MT1-MMP functions in tooth root formation, dentinogenesis, and tooth eruption
Xu, H., Snider, T. N., Wimer, H. F., Yamada, S. S., Yang, T., Holmbeck, Kenn & Foster, B. L., 2016, In: Matrix Biology. 52-54, p. 266-283 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
Mice Deficient in AKAP13 (BRX) Are Osteoporotic and Have Impaired Osteogenesis
Koide, H., Holmbeck, Kenn, Lui, J. C., Guo, X. C., Driggers, P., Chu, T., Tatsuno, I., Quaglieri, C., Kino, T., Baron, J., Young, M. F., Robey, P. G. & Segars, J. H., Oct 2015, In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 30, 10, p. 1887-95 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Osteoblast-specific expression of the fibrous dysplasia (FD)-causing mutation Gsα(R201C) produces a high bone mass phenotype but does not reproduce FD in the mouse
Remoli, C., Michienzi, S., Sacchetti, B., Consiglio, A. D., Cersosimo, S., Spica, E., Robey, P. G., Holmbeck, Kenn, Cumano, A., Boyde, A., Davis, G., Saggio, I., Riminucci, M. & Bianco, P., Jun 2015, In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 30, 6, p. 1030-43 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling
Maeda, A., Ono, M., Holmbeck, Kenn, Li, L., Kilts, T. M., Kram, V., Noonan, M. L., Yoshioka, Y., McNerny, E. M. B., Tantillo, M. A., Kohn, D. H., Lyons, K. M., Robey, P. G. & Young, M. F., 2015, In: The Journal of Biological Chemistry. 290, 22, p. 14004-14018 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
Biglycan modulates angiogenesis and bone formation during fracture healing
Berendsen, A. D., Pinnow, E. L., Maeda, A., Brown, A. C., McCartney-Francis, N., Kram, V., Owens, R. T., Robey, P. G., Holmbeck, Kenn, de Castro, L. F., Kilts, T. M. & Young, M. F., Apr 2014, In: Matrix Biology. 35, p. 223-31 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Constitutive expression of Gsα(R201C) in mice produces a heritable, direct replica of human fibrous dysplasia bone pathology and demonstrates its natural history
Saggio, I., Remoli, C., Spica, E., Cersosimo, S., Sacchetti, B., Robey, P. G., Holmbeck, Kenn, Cumano, A., Boyde, A., Bianco, P. & Riminucci, M., 2014, In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 29, 11, p. 2357-68 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Membrane-type MMPs are indispensable for placental labyrinth formation and development
Szabova, L., Son, M., Shi, J., Sramko, M., Yamada, S. S., Swaim, W. D., Zerfas, P., Kahan, S. & Holmbeck, Kenn, 16 Dec 2010, In: Blood. 116, 25, p. 5752-61 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Carcinomas contain a matrix metalloproteinase-resistant isoform of type I collagen exerting selective support to invasion
Makareeva, E., Han, S., Vera, J. C., Sackett, D. L., Holmbeck, Kenn, Phillips, C. L., Visse, R., Nagase, H. & Leikin, S., 1 Jun 2010, In: Cancer Research. 70, 11, p. 4366-74 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis
Rebustini, I. T., Myers, C., Lassiter, K. S., Surmak, A., Szabova, L., Holmbeck, Kenn, Pedchenko, V., Hudson, B. G. & Hoffman, M. P., Oct 2009, In: Developmental Cell. 17, 4, p. 482-93 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion
Markovic, D. S., Vinnakota, K., Chirasani, S., Synowitz, M., Raguet, H., Stock, K., Sliwa, M., Lehmann, S., Kälin, R., van Rooijen, N., Holmbeck, Kenn, Heppner, F. L., Kiwit, J., Matyash, V., Lehnardt, S., Kaminska, B., Glass, R. & Kettenmann, H., 28 Jul 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 30, p. 12530-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
MT1-MMP is required for efficient tumor dissemination in experimental metastatic disease
Szabova, L., Chrysovergis, K., Yamada, S. S. & Holmbeck, Kenn, 22 May 2008, In: Oncogene. 27, 23, p. 3274-81 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of craniofacial structures in transgenic mice with constitutively active PTH/PTHrP receptor
Tsutsui, T. W., Riminucci, M., Holmbeck, Kenn, Bianco, P. & Robey, P. G., Feb 2008, In: Bone. 42, 2, p. 321-31 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane-type MMPs enable extracellular matrix permissiveness and mesenchymal cell proliferation during embryogenesis
Shi, J., Son, M., Yamada, S., Szabova, L., Kahan, S., Chrysovergis, K., Wolf, L., Surmak, A. & Holmbeck, Kenn, 1 Jan 2008, In: Developmental Biology. 313, 1, p. 196-209 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells
Ingvarsen, S. Z., Madsen, D. H., Hillig, T., Lund, L. R., Holmbeck, Kenn, Behrendt, Niels & Engelholm, L. H., 2008, In: Biological Chemistry. 389, 7, p. 943-953 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation
Madsen, Daniel Hargbøl, Engelholm, Lars Henning, Ingvarsen, S., Hillig, T., Wagenaar-Miller, R. A., Kjøller, L., Gårdsvoll, Henrik, Høyer-Hansen, G., Holmbeck, Kenn, Bugge, T. H. & Behrendt, Niels, 14 Sep 2007, In: The Journal of Biological Chemistry. 282, 37, p. 27037-45 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complementary roles of intracellular and pericellular collagen degradation pathways in vivo
Wagenaar-Miller, R. A., Engelholm, Lars Henning, Gavard, J., Yamada, S. S., Gutkind, J. S., Behrendt, Niels, Bugge, T. H. & Holmbeck, Kenn, Sep 2007, In: Molecular and Cellular Biology. 27, 18, p. 6309-22 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane type 1 matrix metalloproteinase is necessary for distal airway epithelial repair and keratinocyte growth factor receptor expression after acute injury
Atkinson, J. J., Toennies, H. M., Holmbeck, Kenn & Senior, R. M., Sep 2007, In: American Journal of Physiology: Lung Cellular and Molecular Physiology. 293, 3, p. L600-10Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GNAS transcripts in skeletal progenitors: evidence for random asymmetric allelic expression of Gs alpha
Michienzi, S., Cherman, N., Holmbeck, Kenn, Funari, A., Collins, M. T., Bianco, P., Robey, P. G. & Riminucci, M., 15 Aug 2007, In: Human Molecular Genetics. 16, 16, p. 1921-30 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D
Basile, J. R., Holmbeck, Kenn, Bugge, T. H. & Gutkind, J. S., 2 Mar 2007, In: The Journal of Biological Chemistry. 282, 9, p. 6899-905 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo
Zhang, W., Matrisian, L. M., Holmbeck, Kenn, Vick, C. C. & Rosenthal, E. L., 6 Mar 2006, In: BMC Cancer. 6, p. 52Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aspects of extracellular matrix remodeling in development and disease
Holmbeck, Kenn & Szabova, L., Mar 2006, In: Birth Defects Research. Part C: Embryo Today Reviews (Print). 78, 1, p. 11-23 13 p.Research output: Contribution to journal › Review › Research
- 2005
- Published
Expression pattern of four membrane-type matrix metalloproteinases in the normal and diseased mouse mammary gland
Szabova, L., Yamada, S. S., Birkedal-Hansen, H. & Holmbeck, Kenn, Oct 2005, In: Journal of Cellular Physiology. 205, 1, p. 123-32 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells
Filippov, S., Koenig, G. C., Chun, T., Hotary, K. B., Ota, I., Bugge, T. H., Roberts, J. D., Fay, W. P., Birkedal-Hansen, H., Holmbeck, Kenn, Sabeh, F., Allen, E. D. & Weiss, S. J., 5 Sep 2005, In: The Journal of Experimental Medicine. 202, 5, p. 663-71 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An MT1-MMP-PDGF receptor-beta axis regulates mural cell investment of the microvasculature
Lehti, K., Allen, E., Birkedal-Hansen, H., Holmbeck, Kenn, Miyake, Y., Chun, T. & Weiss, S. J., 15 Apr 2005, In: Genes & Development. 19, 8, p. 979-91 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane-type 1 matrix metalloproteinase is required for normal alveolar development
Atkinson, J. J., Holmbeck, Kenn, Yamada, S., Birkedal-Hansen, H., Parks, W. C. & Senior, R. M., Apr 2005, In: Developmental Dynamics. 232, 4, p. 1079-90 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The metalloproteinase MT1-MMP is required for normal development and maintenance of osteocyte processes in bone
Holmbeck, Kenn, Bianco, P., Pidoux, I., Inoue, S., Billinghurst, R. C., Wu, W., Chrysovergis, K., Yamada, S., Birkedal-Hansen, H. & Poole, A. R., 1 Jan 2005, In: Journal of Cell Science. 118, Pt 1, p. 147-56 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Collagenase in cranial morphogenesis
Holmbeck, Kenn, 2005, In: Cells, Tissues, Organs. 181, 3-4, p. 154-65 12 p.Research output: Contribution to journal › Review › Research
- 2004
- Published
MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix
Chun, T., Sabeh, F., Ota, I., Murphy, H., McDonagh, K. T., Holmbeck, Kenn, Birkedal-Hansen, H., Allen, E. D. & Weiss, S. J., 22 Nov 2004, In: The Journal of Cell Biology. 167, 4, p. 757-67 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP
Sabeh, F., Ota, I., Holmbeck, Kenn, Birkedal-Hansen, H., Soloway, P., Balbin, M., Lopez-Otin, C., Shapiro, S., Inada, M., Krane, S., Allen, E., Chung, D. & Weiss, S. J., 22 Nov 2004, In: The Journal of Cell Biology. 167, 4, p. 769-81 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MT1-MMP: a tethered collagenase
Holmbeck, Kenn, Bianco, P., Yamada, S. & Birkedal-Hansen, H., Jul 2004, In: Journal of Cellular Physiology. 200, 1, p. 11-9 9 p.Research output: Contribution to journal › Review › Research
- 2003
- Published
MT1-MMP-dependent, apoptotic remodeling of unmineralized cartilage: a critical process in skeletal growth
Holmbeck, Kenn, Bianco, P., Chrysovergis, K., Yamada, S. & Birkedal-Hansen, H., 10 Nov 2003, In: The Journal of Cell Biology. 163, 3, p. 661-71 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MT1-mmp: a collagenase essential for tumor cell invasive growth
Holmbeck, Kenn, Bianco, P. & Birkedal-Hansen, H., Aug 2003, In: Cancer Cell. 4, 2, p. 83-4 2 p.Research output: Contribution to journal › Journal article › Research
- Published
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion
Engelholm, Lars Henning, List, K., Netzel-Arnett, S., Cukierman, E., Mitola, D. J., Aaronson, H., Kjøller, L., Larsen, J. K., Yamada, K. M., Strickland, D. K., Holmbeck, Kenn, Danø, K., Birkedal-Hansen, H., Behrendt, Niels & Bugge, T. H., 31 Mar 2003, In: Journal of Cell Biology. 160, 7, p. 1009-15 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of molar eruption and root elongation in MT1-MMP-deficient mice
Beertsen, W., Holmbeck, Kenn, Niehof, A., Bianco, P., Chrysovergis, K., Birkedal-Hansen, H. & Everts, V., 2003, In: Connective Tissue Research. 44 Suppl 1, p. 298-9 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
On the role of MT1-MMP, a matrix metalloproteinase essential to collagen remodeling, in murine molar eruption and root growth
Beertsen, W., Holmbeck, Kenn, Niehof, A., Bianco, P., Chrysovergis, K., Birkedal-Hansen, H. & Everts, V., Dec 2002, In: European Journal of Oral Sciences. 110, 6, p. 445-51 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity
Netzel-Arnett, S., Mitola, D. J., Yamada, S. S., Chrysovergis, K., Holmbeck, Kenn, Birkedal-Hansen, H. & Bugge, T. H., 22 Nov 2002, In: The Journal of Biological Chemistry. 277, 47, p. 45154-61 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Matrix metalloproteinases (MMPs) regulate fibrin-invasive activity via MT1-MMP-dependent and -independent processes
Hotary, K. B., Yana, I., Sabeh, F., Li, X., Holmbeck, Kenn, Birkedal-Hansen, H., Allen, E. D., Hiraoka, N. & Weiss, S. J., 4 Feb 2002, In: The Journal of Experimental Medicine. 195, 3, p. 295-308 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An inactivated SARS-CoV-2 vaccine induced cross-neutralizing persisting antibodies and protected against challenge in small animals
Research output: Contribution to journal › Journal article › Research › peer-review
Published