Jens Bukh
Professor
Virology
Blegdamsvej 3B, 2200 København N, 07 Bygning 7, Building: 07-13-84
Member of:
- 2024
- Published
Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice
Brown, A. J., Won, J. J., Wolfisberg, R., Fahnøe, U., Catanzaro, N., West, A., Moreira, F. R., Nogueira Batista, M., Ferris, M. T., Linnertz, C. L., Leist, S. R., Nguyen, C., De La Cruz, G., Midkiff, B. R., Xia, Y., Evangelista, M. D., Montgomery, S. A., Billerbeck, E., Bukh, J., Scheel, T. K. H. & 2 others, , 2024, In: Hepatology. 79, 1, p. 183-197Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutralizing antibody and CD8+ T cell responses following BA.4/5 bivalent COVID-19 booster vaccination in adults with and without prior exposure to SARS-CoV-2
Underwood, Alexander Paul James, Sølund, C., Jacobsen, K., Binderup, A., Fernandez-Antunez, C., Mikkelsen, L. S., Inekci, D., Villadsen, S. L., Castruita, J. A. S., Pinholt, M., Fahnøe, Ulrik, Ramirez, S., Brix, L., Weis, Nina & Bukh, Jens, 2024, In: Frontiers in Immunology. 15, 14 p., 1353353.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
An inactivated SARS-CoV-2 vaccine induced cross-neutralizing persisting antibodies and protected against challenge in small animals
Offersgaard, Anna Falden, Duarte Hernandez, Carlos Rene, Feng, S., Marichal-Gallardo, P., Holmbeck, Kenn, Pihl, A. F., Fernandez-Antunez, C., Alzua, G. P., Hartmann, Katrine Top, Pham, Long, Zhou, Y., Gammeltoft, Karen Anbro, Fahnøe, Ulrik, Schneider, Uffe Vest, Pedersen, Gabriel Kristian, Jensen, Henrik Elvang, Christensen, Jan Pravsgaard, Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: iScience. 26, 2, 105949.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model
Liang, T. J., Law, J. L. M., Pietschmann, T., Ray, S. C., Bukh, Jens, Bull, R., Chung, R. T., Tyrrell, D. L., Houghton, M. & Rice, C. M., 2023, In: Clinical Infectious Diseases. 77, p. S257-S261Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease
Mullari, M., Fossat, Nicolas Julien, Skotte, Niels Henning, Asenjo-Martinez, A., Humphreys, D. T., Bukh, Jens, Kirkeby, Agnete, Scheel, Troels Kasper Høyer & Nielsen, Michael Lund, 2023, In: Nature Communications. 14, 20 p., 4348.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of multi-DAA resistance using a novel hepatitis C virus genotype 3a infectious culture system
Fernandez-Antunez, C., Wang, K., Fahnøe, Ulrik, Mikkelsen, L. S., Gottwein, Judith Margarete, Bukh, Jens & Ramirez Almeida, Santseharay, 2023, In: Hepatology. 78, 2, p. 621-636 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential activity of nucleotide analogs against tick-borne encephalitis and yellow fever viruses in human cell lines
Binderup, A., Galli, Andrea, Fossat, Nicolas Julien, Fernandez-Antunez, C., Mikkelsen, L. S., Rivera, Lizandro, Scheel, Troels Kasper Høyer, Fahnøe, Ulrik, Bukh, Jens & Ramirez, S., 2023, In: Virology. 585, p. 179-185 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Durability and breadth of neutralisation following multiple antigen exposures to SARS-CoV-2 infection and/or COVID-19 vaccination
Underwood, Alexander Paul James, Sølund, C., Fernandez-Antunez, C., Villadsen, S. L., Mikkelsen, L. S., Fahnøe, Ulrik, Bollerup, S., Winckelmann, Anni Assing, Schneider, Uffe Vest, Binderup, A., Vizgirda, G., Sørensen, A. L., Vinten, C. N., Dalegaard, M. I., Ramirez Almeida, Santseharay, Weis, Nina & Bukh, Jens, 2023, In: EBioMedicine. 89, 104475.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of Glycan Shift on Antibodies against Hepatitis C Virus E2 412–425 Epitope Elicited by Chimeric sHBsAg-Based Virus-Like Particles
Czarnota, A., Offersgaard, Anna Falden, Owsianka, A., Alzua, G. P., Bukh, Jens, Gottwein, Judith Margarete, Patel, A. H., Bienkowska-Szewczyk, K. & Grzyb, K., 2023, In: Microbiology Spectrum. 11, 2, 17 p., e0024523.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
First-in-human use of a modular capsid virus-like vaccine platform: An open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2
Smit, M. J., Sander, A. F., Ariaans, M. B. P. A., Fougeroux, C., Heinzel, C., Fendel, R., Esen, M., Kremsner, P. G., Ter Heine, R., Wertheim, H. F., Idorn, M., Paludan, S. R., Underwood, A. P., Binderup, A., Ramirez, S., Bukh, J., Soegaard, M., Erdogan, S. M., Gustavsson, T., Clemmensen, S. & 14 others, , 2023, In: The Lancet Microbe. 4, 3, p. e140-e148Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Full-length sequence analysis of hepatitis C virus genotype 3b strains and development of an in vivo infectious 3b cDNA clone
Bajpai, P. S., Collignon, Laura Maria F, Sølund, C., Madsen, L. W., Christensen, P. B., Øvrehus, A., Weis, Nina, Holmbeck, Kenn, Fahnøe, Ulrik & Bukh, Jens, 2023, In: Journal of Virology. 97, 12, 23 p., 00925.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus RNA is 5'-capped with flavin adenine dinucleotide
Sherwood, A. V., Rivera-Rangel, L. R., Ryberg, L. A., Larsen, H. S., Anker, K. M., Costa, R., Vågbø, C. B., Jakljevič, E., Pham, L. V., Fernandez-Antunez, C., Indrisiunaite, G., Podolska-Charlery, A., Grothen, J. E. R., Langvad, N. W., Fossat, N., Offersgaard, A., Al-Chaer, A., Nielsen, L., Kuśnierczyk, A., Sølund, C. & 8 others, , 2023, In: Nature. 619, p. 811-818Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus alters the morphology and function of peroxisomes
Martin de Fourchambault, E., Callens, N., Saliou, J. M., Fourcot, M., Delos, O., Barois, N., Thorel, Q., Ramirez Almeida, Santseharay, Bukh, Jens, Cocquerel, L., Bertrand-Michel, J., Marot, G., Sebti, Y., Dubuisson, J. & Rouillé, Y., 2023, In: Frontiers in Microbiology. 14, 1254728.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of novel neutralizing determinants for protection against HCV
Alzua, G. P., Pihl, A. F., Offersgaard, Anna Falden, Velázquez-Moctezuma, R., Duarte Hernandez, Carlos Rene, Augestad, Elias Honerød, Fahnøe, Ulrik, Mathiesen, C. K., Krarup, H., Law, M., Prentø, Jannick, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: Hepatology. 73, 3, p. 982-996Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of the viral and cellular microRNA interactomes during SARS-CoV-2 infection
Fossat, Nicolas Julien, Lundsgaard, Emma Alberte, Costa, Rui, Rivera, Lizandro, Nielsen, L., Mikkelsen, L. S., Ramirez Almeida, Santseharay, Bukh, Jens & Scheel, Troels Kasper Høyer, 2023, In: Cell Reports. 42, 4, 112282.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inactivated genotype 1a, 2a and 3a HCV vaccine candidates induced broadly neutralising antibodies in mice
Alzua, G. P., Pihl, A. F., Offersgaard, Anna Falden, Duarte Hernandez, Carlos Rene, Duan, Z., Feng, S., Fahnøe, Ulrik, Sølund, C., Weis, Nina, Law, M., Prentø, Jannick, Christensen, Jan Pravsgaard, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: Gut. 72, 3, p. 560-572Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanisms and Consequences of Genetic Variation in Hepatitis C Virus (HCV)
Galli, Andrea & Bukh, Jens, 2023, Viral Fitness and Evolution: Population Dynamics and Adaptive Mechanisms. Springer, p. 237-264 28 p. (Current Topics in Microbiology and Immunology, Vol. 439).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Molecular Determinants of Mouse Adaptation of Rat Hepacivirus
Wolfisberg, R., Holmbeck, Kenn, Billerbeck, E., Thorselius, Caroline Eva, Batista, M. N., Fahnøe, Ulrik, Lundsgaard, Emma Alberte, Kennedy, Matthew James, Nielsen, L., Rice, C. M., Bukh, Jens & Scheel, Troels Kasper Høyer, 2023, In: Journal of Virology. 97, 4, 17 p., e0181222.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pre-existing, treatment-specific resistance-associated substitutions in hepatitis C virus genotype 1 and 3 and viral RNA titers during treatment with direct-acting antivirals
Sølund, C., Pedersen, M. S., Fahnøe, Ulrik, Filskov, J., Jenssen, H., Weis, Nina, Schønning, Kristian & Bukh, Jens, 2023, In: APMIS. 131, 8, p. 426-433Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Renaming of the genus Flavivirus to Orthoflavivirus and extension of binomial species names within the family Flaviviridae
Postler, T. S., Beer, M., Blitvich, B. J., Bukh, Jens, de Lamballerie, X., Drexler, J. F., Imrie, A., Kapoor, A., Karganova, G. G., Lemey, P., Lohmann, V., Simmonds, P., Smith, D. B., Stapleton, J. T. & Kuhn, J. H., 2023, In: Archives of Virology. 168, 9, 224.Research output: Contribution to journal › Review › Research › peer-review
- Published
SARS-CoV-2 spike HexaPro formulated in aluminium hydroxide and administered in an accelerated vaccination schedule partially protects Syrian Hamsters against viral challenge despite low neutralizing antibody responses
Christensen, D., Polacek, C., Sheward, D. J., Hanke, L., McInerney, G., Murrell, B., Hartmann, Katrine Top, Jensen, Henrik Elvang, Zimmermann, J., Jungersen, G., Illigen, K. E., Isling, L. K., Fernandez-Antunez, C., Ramirez Almeida, Santseharay, Bukh, Jens & Pedersen, Gabriel Kristian, 2023, In: Frontiers in Immunology. 14, 941281.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SARS-CoV-2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID-19 vaccination
Castruita, J. A. S., Schneider, Uffe Vest, Mollerup, S., Leineweber, T. D., Weis, Nina, Bukh, Jens, Pedersen, M. S. & Westh, Henrik T., 2023, In: APMIS. 131, 3, p. 128-132 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substitutions in SARS-CoV-2 Mpro Selected by Protease Inhibitor Boceprevir Confer Resistance to Nirmatrelvir
Gammeltoft, Karen Anbro, Zhou, Y., Ryberg, Line Abildgaard, Pham, Long, Binderup, A., Duarte Hernandez, Carlos Rene, Offersgaard, Anna Falden, Fahnøe, Ulrik, Peters, G. H. J., Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: Viruses. 15, 9, 17 p., 1970.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Role of CTLA-4 in T Cell Exhaustion in Chronic Hepatitis B Virus Infection
Apol, Á. D., Winckelmann, Anni Assing, Duus, R. B., Bukh, Jens & Weis, Nina, 2023, In: Viruses. 15, 5, 1141.Research output: Contribution to journal › Review › Research › peer-review
- Published
Toward a vaccine against hepatitis C virus
Offersgaard, Anna Falden, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: Science. 380, 6640, p. 37-38 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Establishment of high-titer HCV and SARS-CoV-2 production in a scalable packed-bed bioreactor for inactivated vaccines inducing neutralizing antibodies in animals
Offersgaard, A. F., Hernandez, C. R. D., Finne Pihl, A., Feng, S., Marichal-Gallardo, P., Venkatesan, N. P., Lin, X., Fernandez-Antunez, C., Pena Alzua, G., Costa, R., Hartmann, K. T., Pham, L., Zhou, Y., Gammeltoft, K. A., Fahnøe, U., Scheel, T. K. H., Schneider, U. V., Jensen, H. E., Christensen, J. P., Ramirez Almeida, S. & 4 others, , 6 Jul 2022.Research output: Contribution to conference › Poster › Communication
- Published
At the Core of Depression: A Diagnostic Interview of the Core Features of Depression
Bukh, Jens, Fabrazzo, M., Christensen, E. M., Mikkelsen, R. L., Larsen, J. K., Hageman, I., Bendsen, B. B., Bolwig, T., Vinberg, Maj, Bech, P., Dam, O. H., Maj, M. & Kessing, Lars Vedel, 11 Mar 2022, In: Psychopathology. 55, 3-4, p. 219–225 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A distinct dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients
Fahnøe, Ulrik, Ronit, A., Berg, Ronan Martin Griffin, Jørgensen, S. E., Mogensen, T. H., Underwood, Alexander Paul James, Scheel, Troels Kasper Høyer, Bukh, Jens & Plovsing, R. R., 2022, In: The Journal of Infectious Diseases. 226, 12, p. 2137–2141Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analysis of Neutralization Titers against SARS-CoV-2 in Health-Care Workers Vaccinated with Prime-Boost mRNA–mRNA or Vector–mRNA COVID-19 Vaccines
Sølund, C., Underwood, Alexander Paul James, Fernandez-Antunez, C., Bollerup, S., Mikkelsen, L. S., Villadsen, S. L., Fahnøe, Ulrik, Winckelmann, Anni Assing, Feng, S., Nørløv Vinten, C. A., Dalegaard, M. I., Vizgirda, G., Sørensen, A. L., Ramirez Almeida, Santseharay, Bukh, Jens & Weis, Nina, 2022, In: Vaccines. 10, 1, 75.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HCV genome-wide analysis for development of efficient culture systems and unravelling of antiviral resistance in genotype 4
Pham, Long, Pedersen, M. S., Fahnøe, Ulrik, Fernandez-Antunez, C., Humes, D., Schønning, Kristian, Ramirez Almeida, Santseharay & Bukh, Jens, 2022, In: Gut. 71, p. 627-642 20323585.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High recombination rate of hepatitis C virus revealed by a green fluorescent protein reconstitution cell system
Galli, Andrea, Fahnøe, Ulrik & Bukh, Jens, 2022, In: Virus Evolution. 8, 1, veab106.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High‐Titer Hepatitis C Virus Production in a Scalable Single‐Use High Cell Density Bioreactor
Offersgaard, Anna Falden, Duarte Hernandez, C. R., Finne Pihl, A., Prabhakar Venkatesan, N., Krarup, H., Lin, X., Reichl, U., Bukh, Jens, Genzel, Y. & Gottwein, Judith Margarete, 2022, In: Vaccines. 10, 2, 249.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inactivated whole hepatitis C virus vaccine employing a licensed adjuvant elicits cross-genotype neutralizing antibodies in mice
Pihl, A. F., Feng, S., Offersgaard, Anna Falden, Alzua, G. P., Augestad, Elias Honerød, Mathiesen, C. K., Jensen, T. B., Krarup, H., Law, M., Prentø, Jannick, Christensen, Jan Pravsgaard, Bukh, Jens & Gottwein, Judith Margarete, 2022, In: Journal of Hepatology. 76, 5, p. 1051-1061Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutralization and receptor use of infectious culture–derived rat hepacivirus as a model for HCV
Wolfisberg, R., Thorselius, Caroline Eva, Salinas, E., Elrod, E., Trivedi, S., Nielsen, L., Fahnøe, Ulrik, Kapoor, A., Grakoui, A., Rice, C. M., Bukh, Jens, Holmbeck, Kenn & Scheel, Troels Kasper Høyer, 2022, In: Hepatology. 76, 5, p. 1506-1519Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutralizing Antibodies Against Hepatitis C Virus and Their Role in Vaccine Immunity
Bukh, Jens, 2022, In: Gastroenterology. 162, 2, p. 396-398 3 p.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system
Zhou, Y., Gammeltoft, Karen Anbro, Ryberg, Line Abildgaard, Pham, Long, Tjørnelund, H. D., Binderup, A., Duarte Hernandez, Carlos Rene, Fernandez-Antunez, C., Offersgaard, Anna Falden, Fahnøe, Ulrik, Peters, G. H. J., Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2022, In: Science Advances. 8, 51, eadd7197.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel HCV Genotype 4d Infectious Systems and Assessment of Direct-Acting Antivirals and Antibody Neutralization
Pham, Long, Velázquez-Moctezuma, R., Fahnøe, Ulrik, Collignon, Laura Maria F, Bajpai, P., Sølund, C., Weis, Nina, Holmbeck, Kenn, Prentø, Jannick & Bukh, Jens, 2022, In: Viruses. 14, 11, 2527.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel hepatitis B virus reverse transcriptase mutations in patients with sustained viremia despite long-term tenofovir treatment
Winckelmann, Anni Assing, Fahnøe, Ulrik, Bajpai, P. S., Dalegaard, M. I., Lundh, A., Ryom, L., Bukh, Jens & Weis, Nina, 2022, In: Journal of Clinical Virology. 150-151, 6 p., 105159.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protection against SARS-CoV-2 transmission by a parenteral prime—Intranasal boost vaccine strategy
Christensen, D., Polacek, C., Sheward, D. J., Hanke, L., Moliner-morro, A., Mcinerney, G., Murrell, B., Hartmann, Katrine Top, Jensen, Henrik Elvang, Jungersen, G., Illigen, K., Isling, L. K., Jensen, R. F., Hansen, J. S., Rosenkrands, I., Fernandez-antunez, C., Ramirez Almeida, Santseharay, Follmann, F., Bukh, Jens & Pedersen, G. K., 2022, In: EBioMedicine. 84, 104248.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Two-component vaccine consisting of virus-like particles displaying hepatitis C virus envelope protein 2 oligomers
Prentø, Jannick, Janitzek, C. M., Velázquez-Moctezuma, R., Sørensen, Andreas Holst Holmegaard, Jørgensen, T., Clemmensen, S., Soroka, V., Thrane, Susan, Theander, Thor Grundtvig, Nielsen, Morten Agertoug, Salanti, Ali, Bukh, Jens & Sander, Adam F. , 2022, In: npj Vaccines. 7, 148.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Versatile SARS-CoV-2 Reverse-Genetics Systems for the Study of Antiviral Resistance and Replication
Fahnøe, Ulrik, Pham, Long, Fernandez-Antunez, C., Costa, Rui, Rivera, Lizandro, Galli, Andrea, Feng, S., Mikkelsen, L. S., Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay & Bukh, Jens, 2022, In: Viruses. 14, 2, 172.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
In vitro Characterization of Fitness and Convalescent Antibody Neutralization of SARS-CoV-2 Cluster 5 Variant Emerging in Mink at Danish Farms
Lassaunière, R., Fonager, J., Rasmussen, M., Frische, A., Polacek, C., Rasmussen, T. B., Lohse, L., Belsham, Graham John, Underwood, Alexander Paul James, Winckelmann, A. A., Bollerup, S., Bukh, Jens, Weis, Nina, Sækmose, S. G., Aagaard, B., Alfaro-Núñez, A., Mølbak, Kåre, Bøtner, A. & Fomsgaard, A., 2021, In: Frontiers in Microbiology. 12, 9 p., 698944.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vitro adaptation and characterization of attenuated hypervariable region 1 swap chimeras of hepatitis C virus
Olesen, C. H., Augestad, Elias Honerød, Troise, F., Bukh, Jens & Prentø, Jannick, 2021, In: PLOS Pathogens. 17, July, 29 p., e1009720.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens
Prentø, Jannick, Janitzek, C. M., Velázquez-Moctezuma, R., Goksøyr, L., Olsen, Rebecca Wendelboe, Fanalista, Margherita, Augestad, Elias Honerød, Thrane, Susan, Pihl, A. F., Gottwein, Judith Margarete, Sander, Adam F. & Bukh, Jens, 2021, In: PLoS ONE. 16, e0255336.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of a novel hepatitis C virus genotype 1 subtype from a patient failing 4 weeks of glecaprevir-pibrentasvir treatment
Pedersen, M. S., Fahnøe, Ulrik, Madsen, L. W., Christensen, P. B., Øvrehus, A. & Bukh, Jens, 2021, In: Microbiology resource announcements. 10, 41, e00755.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficacy of ion-channel inhibitors amantadine, memantine and rimantadine for the treatment of SARS-CoV-2 in vitro
Zhou, Y., Gammeltoft, Karen Anbro, Galli, Andrea, Offersgaard, Anna Falden, Fahnøe, Ulrik, Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2021, In: Viruses. 13, 10, 2082.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins
Chen, F., Tzarum, N., Lin, X., Giang, E., Velázquez-Moctezuma, R., Augestad, Elias Honerød, Nagy, K., He, L., Hernandez, M., Fouch, M. E., Grinyó, A., Chavez, D., Doranz, B. J., Prentø, Jannick, Stanfield, R. L., Lanford, R., Bukh, Jens, Wilson, I. A., Zhu, J. & Law, M., 2021, In: Immunity. 54, 4, p. 781-796.e4Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Global evolutionary analysis of chronic hepatitis C patients revealed significant effect of baseline viral resistance, including novel non-target sites, for DAA-based treatment and retreatment outcome
Fahnøe, Ulrik, Pedersen, M. S., Sølund, C., Ernst, A., Krarup, H. B., Røge, B. T., Christensen, P. B., Laursen, A. L., Gerstoft, Jan, Thielsen, P., Madsen, Lone Galmstrup, Pedersen, A. G., Schønning, Kristian, Weis, Nina & Bukh, Jens, 2021, In: Journal of Viral Hepatitis. 28, 2, p. 302-316Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2 in Vitro
Gammeltoft, Karen Anbro, Zhou, Y., Duarte Hernandez, C. R., Galli, Andrea, Offersgaard, Anna Falden, Costa, Rui, Pham, Long, Fahnøe, Ulrik, Feng, S., Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 9, e02680-20.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus envelope protein dynamics and the link to hypervariable region 1
Augestad, Elias Honerød, Bukh, Jens & Prentø, Jannick, 2021, In: Current Opinion in Virology. 50, p. 69-75 7 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
In vitro efficacy of artemisinin-based treatments against SARS-CoV-2
Zhou, Y., Gilmore, K., Ramirez Almeida, Santseharay, Settels, E., Gammeltoft, Karen Anbro, Pham, Long, Fahnøe, Ulrik, Feng, S., Offersgaard, Anna Falden, Trimpert, J., Bukh, Jens, Osterrieder, K., Gottwein, Judith Margarete & Seeberger, P. H., 2021, In: Scientific Reports. 11, 14571.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inferior cure rate in pilot study of 4-week glecaprevir/pibrentasvir treatment with or without ribavirin of chronic hepatitis C
Madsen, L. W., Christensen, P. B., Fahnøe, Ulrik, Pedersen, M. S., Bukh, Jens & Øvrehus, A., 2021, In: Liver International. 41, 11, p. 2601-2610Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipid Droplets Accumulation during Hepatitis C Virus Infection in Cell-Culture Varies among Genotype 1-3 Strains and Does Not Correlate with Virus Replication
Galli, Andrea, Ramirez Almeida, Santseharay & Bukh, Jens, 2021, In: Viruses. 13, 3, 389.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutralisation titres against SARS-CoV-2 are sustained 6 months after onset of symptoms in individuals with mild COVID-19
Underwood, Alexander Paul James, Sølund, C., Fernandez-Antunez, C., Villadsen, S. L., Winckelmann, A. A., Bollerup, S., Mikkelsen, L. S., Sørensen, A. L., Feng, S., Fahnøe, Ulrik, Lassauniere, R., Fomsgaard, A., Ramirez Almeida, Santseharay, Weis, Nina & Bukh, Jens, 2021, In: EBioMedicine. 71, 103519.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Overcoming culture restriction for SARS-CoV-2 in human cells facilitates the screening of compounds inhibiting viral replication
Ramirez Almeida, Santseharay, Fernandez-Antunez, C., Galli, Andrea, Underwood, Alexander Paul James, Pham, Long, Ryberg, Line Abildgaard, Feng, S., Pedersen, M. S., Mikkelsen, L. S., Belouzard, S., Dubuisson, J., Sølund, C., Weis, Nina, Gottwein, Judith Margarete, Fahnøe, Ulrik & Bukh, Jens, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 7, 20 p., e00097-21.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pathogenesis, miR-122 gene-regulation, and protective immune responses after acute equine hepacivirus infection
Tomlinson, J. E., Wolfisberg, R., Fahnøe, Ulrik, Patel, R. S., Trivedi, S., Kumar, A., Sharma, H., Nielsen, L., McDonough, S. P., Bukh, Jens, Tennant, B. C., Kapoor, A., Rosenberg, B. R., Rice, C. M., Divers, T. J., Van de Walle, G. R. & Scheel, Troels Kasper Høyer, 2021, In: Hepatology. 74, 3, p. 1148-1163Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sars-cov-2 production in a scalable high cell density bioreactor
Offersgaard, Anna Falden, Hernandez, C. R. D., Pihl, A. F., Costa, Rui, Venkatesan, N. P., Lin, X., Pham, Long, Feng, S., Fahnøe, Ulrik, Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Reichl, U., Bukh, Jens, Genzel, Y. & Gottwein, Judith Margarete, 2021, In: Vaccines. 9, 7, 706.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vaccines against hepatitis C: A travel into neutralisation space
Bukh, Jens, 2021, In: Gut. 70, 9, p. 1609-1610 2 p., 323377.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure
STOP-HCV Consortium, S. C., 2021, In: Nature Communications. 12, 1, 11 p., 6105.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Evolutionary selection of pestivirus variants with altered or no microRNA dependency
Kokkonos, K. G., Fossat, Nicolas Julien, Nielsen, L., Holm, C., Hepkema, W. M., Bukh, Jens & Scheel, Troels Kasper Høyer, 4 Jun 2020, In: Nucleic Acids Research. 48, 10, p. 5555-5571 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An alternate conformation of HCV E2 neutralizing face as an additional vaccine target
Tzarum, N., Giang, E., Kadam, R. U., Chen, F., Nagy, K., Augestad, E. H., Velázquez-Moctezuma, R., Keck, Z. Y., Hua, Y., Stanfield, R. L., Dreux, M., Prentø, Jannick, Foung, S. K. H., Bukh, Jens, Wilson, I. A. & Law, M., 2020, In: Science Advances. 6, 30, abb5642.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analysis of virus population profiles within pigs infected with virulent Classical Swine Fever viruses; evidence for bottlenecks in transmission but absence of tissue specific virus variants
Johnston, C. M., Fahnøe, Ulrik, Lohse, L., Bukh, Jens, Belsham, Graham John & Rasmussen, T. B., 2020, In: Journal of Virology. 94, 19, 20 p., e01119-20.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antibody Responses to Immunization With HCV Envelope Glycoproteins as a Baseline for B-Cell–Based Vaccine Development
Chen, F., Nagy, K., Chavez, D., Willis, S., McBride, R., Giang, E., Honda, A., Bukh, Jens, Ordoukhanian, P., Zhu, J., Frey, S., Lanford, R. & Law, M., 2020, In: Gastroenterology. 158, 4, p. 1058-1071.e6Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell culture studies of the efficacy and barrier to resistance of sofosbuvir-velpatasvir and glecaprevir-pibrentasvir against hepatitis C virus genotypes 2a, 2b, and 2C
Ramirez Almeida, Santseharay, Fernandez-Antunez, C., Mikkelsen, L. S., Pedersen, J., Li, Y. P. & Bukh, Jens, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 3, e01888.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of a downstream process for the production of an inactivated whole hepatitis C virus vaccine
Lothert, K., Offersgaard, A. F., Pihl, A. F., Mathiesen, C. K., Jensen, T. B., Alzua, G. P., Fahnøe, Ulrik, Bukh, Jens, Gottwein, Judith Margarete & Wolff, M. W., 2020, In: Scientific Reports. 10, 13 p., 16261.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient culture of SARS-CoV-2 in human hepatoma cells enhances viability of the virus in human lung cancer cell lines permitting the screening of antiviral compounds
Ramirez Almeida, Santseharay, Fernandez-Antunez, C., Pham, Long, Ryberg, Line Abildgaard, Feng, S., Pedersen, M. S., Mikkelsen, L. S., Belouzard, S., Dubuisson, J., Gottwein, Judith Margarete, Fahnøe, Ulrik & Bukh, Jens, 2020, bioRxiv.Research output: Working paper › Preprint › Research
- Published
Elimination af hepatitis C-virus i Danmark
Døssing, A., Røge, B. T., Madsen, Lone Galmstrup, Laursen, A. L., Hansen, J. B., Bukh, Jens & Weis, Nina, 2020, In: Ugeskrift for Laeger. 182, 9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Equine pegiviruses cause persistent infection of bone marrow and are not associated with hepatitis
Tomlinson, J. E., Wolfisberg, R., Fahnøe, Ulrik, Sharma, H., Renshaw, R. W., Nielsen, L., Nishiuchi, E., Holm, C., Dubovi, E., Rosenberg, B. R., Tennant, B. C., Bukh, Jens, Kapoor, A., Divers, T. J., Rice, C. M., Van de Walle, G. R. & Scheel, Troels Kasper Høyer, 2020, In: P L o S Pathogens. 16, 7, 23 p., e1008677.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Global and local envelope protein dynamics of hepatitis C virus determine broad antibody sensitivity
Augestad, E. H., Castelli, M., Clementi, N., Ströh, L. J., Krey, T., Burioni, R., Mancini, N., Bukh, Jens & Prentø, Jannick, 2020, In: Science Advances. 6, 35, 13 p., eabb5938.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of specific amino acid residues in the border disease virus glycoprotein E2 that modify virus growth in pig cells but not in sheep cells
Fahnøe, Ulrik, Deng, Y., Davids, N. A., Lohse, L., Bukh, Jens, Belsham, Graham John & Rasmussen, T. B., 2020, In: The Journal of general virology. 101, 11, p. 1170-1181Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insights into the unique characteristics of hepatitis C virus genotype 3 revealed by development of a robust sub-genomic DBN3a replicon
Ward, J. C., Bowyer, S., Chen, S., Fernandes Campos, G. R., Ramirez Almeida, Santseharay, Bukh, Jens & Harris, M., 2020, In: The Journal of general virology. 101, 11, p. 1182-1190 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutations Identified in the Hepatitis C Virus (HCV) Polymerase of Patients with Chronic HCV Treated with Ribavirin Cause Resistance and Affect Viral Replication Fidelity
Mejer, N., Fahnøe, Ulrik, Galli, Andrea, Ramirez Almeida, Santseharay, Weiland, O., Benfield, Thomas & Bukh, Jens, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 12Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reflections on the History of HCV: A Posthumous Examination
Alter, H. J., Farci, P., Bukh, Jens & Purcell, R. H., 2020, In: Clinical Liver Disease. 15, S1, p. S64-S71Research output: Contribution to journal › Review › Research › peer-review
- Published
Ribavirin inhibition of cell-culture infectious hepatitis C genotype 1-3 viruses is strain-dependent
Mejer, N., Galli, Andrea, Ramirez Almeida, Santseharay, Fahnøe, Ulrik, Benfield, Thomas & Bukh, Jens, 2020, In: Virology. 540, p. 132-140 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Specific antibodies induced by immunization with hepatitis B virus-like particles carrying hepatitis C virus envelope glycoprotein 2 epitopes show differential neutralization efficiency
Czarnota, A., Offersgaard, A., Pihl, A. F., Prentø, Jannick, Bukh, Jens, Gottwein, Judith Margarete, Bieńkowska-Szewczyk, K. & Grzyb, K., 2020, In: Vaccines. 8, 2, 19 p., 294.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis c virus infections uncover molecular determinants for E2 targeting and vaccine design
Keck, Z. Y., Pierce, B. G., Lau, P., Lu, J., Wang, Y., Underwood, A., Bull, R. A., Prentø, Jannick, Velázquez-Moctezuma, R., Walker, Melanie Rose, Luciani, F., Guest, J. D., Fauvelle, C., Baumert, T. F., Bukh, Jens, Lloyd, A. R. & Foung, S. K. H., 2019, In: P L o S Pathogens. 15, 5, 28 p., e1007772.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants
Jensen, S. B., Fahnøe, U., Pham, L. V., Serre, S. B. N., Tang, Q., Ghanem, L., Pedersen, M. S., Ramirez, S., Humes, D., Pihl, A. F., Filskov, J., Sølund, C. S., Dietz, J., Fourati, S., Pawlotsky, J. M., Sarrazin, C., Weis, N., Schønning, K., Krarup, H., Bukh, J. & 1 others, , 2019, In: Hepatology. 70, 3, p. 771-787 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Full-length open reading frame amplification of hepatitis C virus
Fahnøe, Ulrik & Bukh, Jens, 2019, Hepatitis C Virus Protocols. Humana Press, p. 85-91 7 p. (Methods in Molecular Biology, Vol. 1911).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies
Tzarum, N., Giang, E., Kong, L., He, L., Prentø, Jannick, Augestad, E., Hua, Y., Castillo, S., Lauer, G. M., Bukh, Jens, Zhu, J., Wilson, I. A. & Law, M., 2019, In: Science Advances. 5, 1, 12 p., eaav1882.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome sequence of an unknown subtype of hepatitis C virus genotype 6: Another piece for the taxonomic puzzle
Pedersen, M. S., Mollerup, S., Nielsen, L. G., Jenssen, H., Bukh, Jens & Schønning, Kristian, 2019, In: Microbiology resource announcements. 8, 42, e01030-19.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape
Pham, Long, Jensen, S. B., Fahnøe, Ulrik, Pedersen, M. S., Tang, Q., Ghanem, L., Ramirez Almeida, Santseharay, Humes, D., Serre, S. B. N., Schønning, Kristian, Bukh, Jens & Gottwein, Judith Margarete, 2019, In: Journal of Hepatology. 70, 3, p. 388-397Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HCV p7 as a novel vaccine-target inducing multifunctional CD4+ and CD8+ T-cells targeting liver cells expressing the viral antigen
Filskov, J., Andersen, P., Agger, E. M. & Bukh, Jens, 2019, In: Scientific Reports. 9, 1, 13 p., 14085.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C Virus–Escape Studies for Human Monoclonal Antibody AR4A Reveal Isolate-Specific Resistance and a High Barrier to Resistance
Velázquez-moctezuma, R., Galli, Andrea, Law, M., Bukh, Jens & Prentø, Jannick, 2019, In: The Journal of Infectious Diseases. 219, 1, p. 68-79Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus escape studies of human antibody AR3a reveal a high barrier to resistance and novel insights on viral antibody evasion mechanisms
Velázquez-Moctezuma, R., Galli, Andrea, Law, M., Bukh, Jens & Prentø, Jannick, 2019, In: Journal of Virology. 93, 4, 27 p., e0190918.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations
Prentø, Jannick, Velázquez-Moctezuma, R., Augestad, E. H., Galli, Andrea, Wang, R., Law, M., Alter, H. & Bukh, Jens, 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10039-10047 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vitro neutralization assay using cultured hepatitis C virus
Prentø, Jannick & Bukh, Jens, 2019, Hepatitis C Virus Protocols. Humana Press, p. 433-439 7 p. (Methods in Molecular Biology, Vol. 1911).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Replicons of a Rodent Hepatitis C Model Virus Permit Selection of Highly Permissive Cells
Wolfisberg, R., Holmbeck, Kenn, Nielsen, L., Kapoor, A., Rice, C. M., Bukh, Jens & Scheel, Troels Kasper Høyer, 2019, In: Journal of Virology. 93, 19, 19 p., e00733-19.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Virus adaptation and selection following challenge of animals vaccinated against classical swine fever virus
Fahnøe, Ulrik, Pedersen, A. G., Johnston, C. M., Orton, R. J., Höper, D., Beer, M., Bukh, Jens, Belsham, Graham John & Rasmussen, T. B., 2019, In: Viruses. 11, 10, 932.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry
Riva, L., Song, O., Prentø, Jannick, Helle, F., L'homme, L., Gattolliat, C., Vandeputte, A., Feneant, L., Belouzard, S., Baumert, T. F., Asselah, T., Bukh, Jens, Brodin, P., Cocquerel, L., Rouille, Y. & Dubuisson, J., 1 May 2018, In: Journal of Virology. 92, 10, 19 p., e01982-17.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficacy of NS5A Inhibitors Against Hepatitis C Virus Genotypes 1–7 and Escape Variants
Gottwein, Judith Margarete, Pham, Long, Mikkelsen, L. S., Ghanem, L., Ramirez Almeida, Santseharay, Scheel, Troels Kasper Høyer, Carlsen, T. H. R. & Bukh, Jens, Apr 2018, In: Gastroenterology. 154, 5, p. 1435-1448 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A near full-length open reading frame next generation sequencing assay for genotyping and identification of resistance-associated variants in hepatitis C virus
Pedersen, M. S., Fahnøe, Ulrik, Hansen, T. A., Pedersen, A. G., Jenssen, H., Bukh, Jens & Schønning, Kristian, 2018, In: Journal of Clinical Virology. 105, p. 49-56 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model
Galli, Andrea, Mens, H., Gottwein, Judith Margarete, Gerstoft, Jan & Bukh, Jens, 2018, In: Scientific Reports. 8, 1, 13 p., 4619.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies
Bartenschlager, R., Baumert, T. F., Bukh, Jens, Houghton, M., Lemon, S. M., Lindenbach, B. D., Lohmann, V., Moradpour, D., Pietschmann, T., Rice, C. M., Thimme, R. & Wakita, T., 2018, In: Virus Research. 248, p. 53-62 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Current status and future development of infectious cell-culture models for the major genotypes of hepatitis C virus: Essential tools in testing of antivirals and emerging vaccine strategies
Ramirez Almeida, Santseharay & Bukh, Jens, 2018, In: Antiviral Research. 158, p. 264-287 24 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Direct acting antiviral treatment of chronic hepatitis C in Denmark: factors associated with and barriers to treatment initiation
Sølund, C., Hallager, S., Pedersen, M. S., Fahnøe, Ulrik, Ernst, A., Krarup, H. B., Røge, B. T., Christensen, P. B., Laursen, A. L., Gerstoft, Jan, Bélard, E., Madsen, Lone Galmstrup, Schønning, Kristian, Pedersen, A. G., Bukh, Jens, Weis, Nina & DANHEP Group, D. G., 2018, In: Scandinavian Journal of Gastroenterology. 53, 7, p. 849-856 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HCV Genotype 6a Escape from and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models
Pham, Long, Ramirez Almeida, Santseharay, Gottwein, Judith Margarete, Fahnøe, Ulrik, Li, Y., Pedersen, J. & Bukh, Jens, 2018, In: Gastroenterology. 154, 8, p. 2194-2208.e12Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals
Pihl, A. F., Offersgaard, A. F., Mathiesen, C. K., Prentø, Jannick, Fahnøe, Ulrik, Krarup, H., Bukh, Jens & Gottwein, Judith Margarete, 2018, In: Scientific Reports. 8, 1, 13 p., 17505.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry
Prentø, Jannick & Bukh, Jens, 2018, In: Frontiers in Immunology. 9, 11 p., 2146.Research output: Contribution to journal › Review › Research › peer-review
- Published
Outcome and adverse events in patients with chronic hepatitis C treated with direct-acting antivirals: A clinical randomized study
Sølund, C., cgl303, cgl303, Mössner, B., Laursen, A. L., Røge, B. T., Kjær, M. S., Gerstoft, Jan, Christensen, P. B., Pedersen, M. S., Schønning, Kristian, Fahnøe, Ulrik, Bukh, Jens & Weis, Nina, 2018, In: European Journal of Gastroenterology and Hepatology. 30, 10, p. 1177-1186 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recombinant hepatitis C virus genotype 5a infectious cell culture systems expressing minimal JFH1 NS5B sequences permit polymerase inhibitor studies
Humes, D., Ramirez Almeida, Santseharay, Jensen, T. B., Li, Y. P., Gottwein, Judith Margarete & Bukh, Jens, 2018, In: Virology. 522, p. 177-192 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ribavirin-induced mutagenesis across the complete open reading frame of hepatitis C virus genotypes 1a and 3a
Mejer, N., Fahnøe, Ulrik, Galli, Andrea, Ramirez Almeida, Santseharay, Benfield, Thomas & Bukh, Jens, 2018, In: Journal of General Virology. 99, 8, p. 1066-1077 12 p., 001095.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Broadening CD4(+) and CD8(+) T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes
Filskov, J., Mikkelsen, M., Hansen, Paul Robert, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Andersen, P., Bukh, Jens & Agger, E., Jul 2017, In: Journal of Virology. 91, 14, 18 p., e00130-17.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A
Velazquez-Moctezuma, R., Law, M., Bukh, Jens & Prentø, Jannick, Feb 2017, In: PLOS Pathogens. 13, 2, 29 p., 1006214.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient hepatitis c virus genotype 1b core-NS5A recombinants permit efficacy testing of protease and NS5A inhibitors
Pham, Long, Ramirez Almeida, Santseharay, Carlsen, T. H. R., Li, Y., Gottwein, Judith Margarete & Bukh, Jens, 2017, In: Antimicrobial Agents and Chemotherapy. 61, 6, 19 p., e00037-17.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mouse models of acute and chronic hepacivirus infection
Billerbeck, E., Wolfisberg, R., Fahnøe, Ulrik, Xiao, J. W., Quirk, C., Luna, J. M., Cullen, J. M., Hartlage, A. S., Chiriboga, L., Ghoshal, K., Lipkin, W. I., Bukh, Jens, Scheel, Troels Kasper Høyer, Kapoor, A. & Rice, C. M., 2017, In: Science. 357, 6347, p. 204-208 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae
Smith, D. B., Meyers, G., Bukh, Jens, Gould, E. A., Monath, T., Muerhoff, A. S., Pletnev, A., Rico-Hesse, R., Stapleton, J. T., Simmonds, P. & Becher, P., 2017, In: Journal of General Virology. 98, 8, p. 2106-2112 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice
Prentø, Jannick, Verhoye, L., Moctezuma, R. V., Buysschaert, C., Farhoudi, A., Wang, R., Alter, H., Meuleman, P. & Bukh, Jens, Dec 2016, In: Gut. 65, 12, p. 1988-1997 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypervariable Region 1 Shielding of Hepatitis C Virus Is a Main Contributor to Genotypic Differences in Neutralization Sensitivity
Prentø, Jannick, Velazquez-Moctezuma, R., Foung, S. K. H., Law, M. & Bukh, Jens, Dec 2016, In: Hepatology. 64, 6, p. 1881-1892 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family
Smith, D. B., Becher, P., Bukh, Jens, Gould, E. A., Meyers, G., Monath, T., Muerhoff, A. S., Pletnev, A., Rico-Hesse, R., Stapleton, J. T. & Simmonds, P., Nov 2016, In: Journal of General Virology. 97, p. 2894-2907 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir
Ramirez Almeida, Santseharay, Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Nov 2016, In: Gastroenterology. 151, 5, p. 973-985.e2Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutralizing antibodies in patients with chronic hepatitis C and correlation to liver cirrhosis and estimated duration of infection
Pedersen, J., Lundbo, L. F., Krarup, H., Bukh, Jens & Weis, Nina, Oct 2016, In: Journal of Medical Virology. 88, 10, p. 1791-1803 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control
Bukh, Jens, Oct 2016, In: Journal of Hepatology. 65, 1 Suppl., p. S2-S21Research output: Contribution to journal › Review › Research › peer-review
- Published
Functional analysis of microRNA-122 binding sequences of hepatitis C virus and identification of variants with high resistance against specific antagomir
Li, Y., Pham, Long, Uzcategui, N. & Bukh, Jens, Jun 2016, In: Journal of General Virology. 97, p. 1381-1394Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.
Serre, S., Jensen, S., Ghanem, L., Humes, D., Ramirez, S., Li, Y., Krarup, H., Bukh, Jens & Gottwein, Judith Margarete, Jun 2016, In: Antimicrobial Agents and Chemotherapy. 60, 6, p. 3563-3578 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor Resistance
Jensen, S. B., Serre, S. B. N., Humes, D. G., Ramirez Almeida, Santseharay, Li, Y., Bukh, Jens & Gottwein, Judith Margarete, Dec 2015, In: Antimicrobial Agents and Chemotherapy. 59, 12, p. 7426-7436 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge
Bukh, Jens, Engle, R. E., Faulk, K., Wang, R. Y., Farci, P., Alter, H. J. & Purcell, R. H., Sep 2015, In: Journal of Virology. 89, 17, p. 9128-9132 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant
Mathiesen, C. K., Prentø, Jannick, Meredith, L. W., Jensen, T. B., Krarup, H., McKeating, J. A., Gottwein, Judith Margarete & Bukh, Jens, Aug 2015, In: Journal of Virology. 89, 15, p. 7758-7775 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell culture system of a hepatitis C genotype 3a and 2a chimera: Patent #: 8,945,584
Gottwein, Judith Margarete, Scheel, T. K. H., Eugen-Olsen, J. & Bukh, Jens, 3 Feb 2015, IPC No. A61K 39/29 (20060101); C12N 15/06 (20060101); C12Q 1/02 (20060101); C07H 21/00 (20060101); C12N 7/02 (20060101); A61K 39/12 (20060101), Patent No. WO2008/125117, 23 Oct 2008, Priority date 11 Apr 2008, Priority No. PCT/DK2008/050083Research output: Patent
- Published
Infectious hepatitis C viruses of genotype 3A and 4A and uses thereof: Patent #: 8,946,398
Gottwein, Judith Margarete, Scheel, T. K. H., Purcell, R. E. & Bukh, Jens, 3 Feb 2015, IPC No. C07H 21/04 (20060101); C07H 21/02 (20060101), Patent No. WO2011/038737, 26 Jul 2012, Priority date 16 Sep 2010, Priority No. PCT/DK2010/050236Research output: Patent
- Published
Efficient infectious cell culture systems of the hepatitis C virus (HCV) prototype strains HCV-1 and H77
Li, Y., Ramirez Almeida, Santseharay, Mikkelsen, L. & Bukh, Jens, Jan 2015, In: Journal of Virology. 89, 1, p. 811-23 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a
Carlsen, T. H. R., Pedersen, J., Prentø, Jannick, Giang, E., Keck, Z., Mikkelsen, L. S., Law, M., Foung, S. K. H. & Bukh, Jens, Nov 2014, In: Hepatology. 60, 5, p. 1551-62 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transfusion-associated hepatitis before the screening of blood for hepatitis risk factors
Engle, R. E., Bukh, Jens, Alter, H. J., Emerson, S. U., Trenbeath, J. L., Nguyen, H. T., Brockington, A., Mitra, T. & Purcell, R. H., Nov 2014, In: Transfusion. 54, 11, p. 2833-41 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Infectious genotype 1a, 1b, 2a, 2b, 3a, 5a, 6a and 7a hepatitis C virus lacking the hypervariable region 1 (HVR1): Patent #: 8,846,891
Prentø, Jannick, Gottwein, Judith Margarete, Scheel, T. K. H., Bukh, Jens & Jensen, T. B., 30 Sep 2014, IPC No. C07H 21/04 (20060101); C07H 21/02 (20060101), Patent No. WO2010/022727, 4 Mar 2010, Priority date 7 Aug 2009, Priority No. PCT/DK2009/050197Research output: Patent
- Published
Genetic variation in toll-like receptors and retinoic acid-inducible gene I and outcome of hepatitis C virus infection: a candidate gene association study
Clausen, L. N., Ladelund, S., Weis, Nina, Bukh, Jens & Benfield, Thomas, Aug 2014, In: Journal of Viral Hepatitis. 21, 8, p. 578-84 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus expressing reporter tagged NS5A protein: Patent #: 8,772,022
Gottwein, Judith Margarete, Scheel, T. K. H., Bukh, Jens, Prentø, Jannick & Jensen, T. B., 8 Jul 2014, IPC No. C12N 15/00 (20060101); C12N 5/00 (20060101); C12N 7/00 (20060101); C12N 15/64 (20060101); A61K 39/29 (20060101); C12N 7/01 (20060101), Patent No. WO2010/037403, 8 Apr 2010, Priority date 5 Oct 2009, Priority No. PCT/DK2009/050263Research output: Patent
- Published
Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus
Galli, A. & Bukh, Jens, Jun 2014, In: Trends in Microbiology. 22, 6, p. 354-64 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6
Mathiesen, C. K., Jensen, T. B., Prentø, Jannick, Krarup, H., Nicosia, A., Law, M., Bukh, Jens & Gottwein, Judith Margarete, Jun 2014, In: Virology. 458-459, p. 190-208 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents
Xiao, F., Fofana, I., Heydmann, L., Barth, H., Soulier, E., Habersetzer, F., Doffoël, M., Bukh, Jens, Patel, A. H., Zeisel, M. B. & Baumert, T. F., May 2014, In: P L o S Pathogens. 10, 5, p. 1-15 16 p., e1004128.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient cell culture system for hepatitis C virus genotype 2B: Patent #: 8,663,653
Gottwein, Judith Margarete, Knudsen, M. L., Scheel, T. K. H. & Bukh, Jens, 31 Mar 2014, IPC No. A61K 39/12 (20060101); A61K 39/29 (20060101); C12N 1/20 (20060101); C12N 5/071 (20100101); C12N 15/00 (20060101); C12Q 1/70 (20060101), Patent No. WO2010/017818, 18 Feb 2010, Priority date 24 Jul 2009, Priority No. PCT/DK2009/050189Research output: Patent
- Published
Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors
Li, Y., Ramirez, S., Humes, D., Jensen, S. B., Gottwein, Judith Margarete & Bukh, Jens, Mar 2014, In: Gastroenterology. 146, 3, p. 812-821.e4 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors
Ramirez, S., Li, Y., Jensen, S. B., Pedersen, J., Gottwein, Judith Margarete & Bukh, Jens, Feb 2014, In: Hepatology. 59, 2, p. 395-407 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypervariable region 1 deletion and required adaptive envelope mutations confer decreased dependency on scavenger receptor class B type I and low-density lipoprotein receptor for hepatitis C virus
Prentø, Jannick, Serre, S. B. N., Ramirez, S., Nicosia, A. & Bukh, Jens, Feb 2014, In: Journal of Virology. 88, 3, p. 1725-39 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource
Smith, D. B., Bukh, Jens, Kuiken, C., Muerhoff, A. S., Rice, C. M., Stapleton, J. T. & Simmonds, P., Jan 2014, In: Hepatology. 59, 1, p. 318-27 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nationwide experience of treatment with protease inhibitors in chronic hepatitis C patients in denmark: identification of viral resistance mutations
Sølund, C., Krarup, H., Ramirez Almeida, Santseharay, Thielsen, P., Røge, B. T., Lunding, S., Barfod, Toke Seierøe, Madsen, Lone Galmstrup, Tarp, B., Christensen, P. B., Gerstoft, Jan, Laursen, A. L., Bukh, Jens, Weis, Nina & DANHEP Group, D. G., 2014, In: PLOS ONE. 9, 12, p. 1-20 20 p., e113034.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Efficient cell culture system for hepatitis C virus genotype 5A: Patent #: 8,618,275
Jensen, T. B., Gottwein, Judith Margarete, Scheel, T. K. H., Eugen-Olsen, J. & Bukh, Jens, 31 Dec 2013, IPC No. C07H 21/00 (20060101); C12N 7/00 (20060101); A61K 39/295 (20060101); A61K 39/12 (20060101); A61K 39/29 (20060101), Patent No. WO2008/141651, 27 Nov 2008, Priority date 19 May 2008, Priority No. PCT/DK2008/050113Research output: Patent
- Published
Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor
Gottwein, Judith Margarete, Jensen, S. B., Serre, S. B. N., Ghanem, L., Scheel, Troels Kasper Høyer, Jensen, T. B., Krarup, H., Uzcategui, N., Mikkelsen, L. S. & Bukh, Jens, Dec 2013, In: Antimicrobial Agents and Chemotherapy. 57, 12, p. 6034-49 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of alpha interferon-induced envelope mutations of hepatitis C virus in vitro associated with increased viral fitness and interferon resistance
Serre, S. B. N., Krarup, H. B., Bukh, Jens & Gottwein, Judith Margarete, Dec 2013, In: Journal of Virology. 87, 23, p. 12776-93 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Persistent human hepatitis B virus infection in cynomolgus monkeys: a novel animal model in the search for a cure?
Bukh, Jens, Lanford, R. E. & Purcell, R. H., Nov 2013, In: Hepatology. 58, 5, p. 1533-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient cell culture system for hepatitis C virus genotype 6A: Patent #: 8,569,472
Gottwein, Judith Margarete, Scheel, T. K. H., Jensen, T. B. & Bukh, Jens, 29 Oct 2013, IPC No. C07H 21/00 (20060101); C12N 7/00 (20060101); A61K 39/295 (20060101); A61K 39/12 (20060101); A61K 39/29 (20060101), Patent No. WO2009/080052, 2 Jul 2009, Priority date 19 Dec 2008, Priority No. PCT/DK2008/050332Research output: Patent
- Published
Efficient cell culture system for hepatitis C virus genotype 1a and 1b: Patent #: 8,563,706
Scheel, T. K. H., Gottwein, Judith Margarete, Prentø, Jannick, Jensen, T. B. & Bukh, Jens, 22 Oct 2013, IPC No. C07H 21/00 (20060101); A61K 39/29 (20060101); A61K 39/12 (20060101); A61K 39/295 (20060101); C12N 7/00 (20060101), Patent No. WO2009/080053, 2 Jul 2009, Priority date 19 Dec 2008, Priority No. PCT/DK2008/050333Research output: Patent
- Published
Analysis of hepatitis C virus core/NS5A protein co-localization using novel cell culture systems expressing core-NS2 and NS5A of genotypes 1-7
Galli, A., Scheel, Troels Kasper Høyer, Prentø, Jannick, Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Oct 2013, In: The Journal of general virology. 94, Pt 10, p. 2221-35 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Viral hepatitis: Cell-culture-derived HCV--a promising vaccine antigen
Gottwein, Judith Margarete & Bukh, Jens, Sep 2013, In: Nature Reviews. Gastroenterology & Hepatology. 10, 9, p. 508-9 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient cell culture system for hepatitis C virus genotype 7a: Patent #: 8,506,969
Gottwein, Judith Margarete, Scheel, T. K. H., Jensen, T. B. & Bukh, Jens, 13 Aug 2013, IPC No. A61K 39/12 (20060101); A61K 39/29 (20060101); C12Q 1/70 (20060101); C12N 15/00 (20060101); C12N 5/071 (20100101); C12N 1/20 (20060101), Patent No. WO2010/017819, 18 Feb 2010, Priority date 31 Jul 2009, Priority No. PCT/DK2009/050193Research output: Patent
- Published
Adaptive mutations allow establishment of JFH1-based cell culture systems for hepatitis C virus genotype 4A: Patent #: 8,454,974
Scheel, T. K. H., Gottwein, Judith Margarete, Eugen-Olsen, J. & Bukh, Jens, 4 Jun 2013, IPC No. A61K 39/29 (20060101); C07H 21/00 (20060101); C12N 15/06 (20060101); C12N 7/02 (20060101); C12Q 1/02 (20060101), Patent No. WO2008/125119, 23 Oct 2008, Priority date 11 Apr 2008, Priority No. PCT/DK2008/050085Research output: Patent
- Published
Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses
Gottwein, Judith Margarete, Jensen, S. B., Li, Y., Ghanem, L., Scheel, Troels Kasper Høyer, Serre, S. B. N., Mikkelsen, L. & Bukh, Jens, Mar 2013, In: Antimicrobial Agents and Chemotherapy. 57, 3, p. 1291-303 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Productive homologous and non-homologous recombination of hepatitis C virus in cell culture
Scheel, Troels Kasper Høyer, Galli, A., Li, Y., Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Mar 2013, In: P L o S Pathogens. 9, 3, p. 1-12 13 p., e1003228.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans
Law, J. L. M., Chen, C., Wong, J., Hockman, D., Santer, D. M., Frey, S. E., Belshe, R. B., Wakita, T., Bukh, Jens, Jones, C. T., Rice, C. M., Abrignani, S., Tyrrell, D. L. & Houghton, M., 2013, In: PloS one. 8, 3, p. 1-7 8 p., e59776.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of hepatitis C virus recombinants with chimeric E1/E2 envelope proteins and identification of single amino acids in the E2 stem region important for entry
Carlsen, T. H. R., Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Foung, S. K. H. & Bukh, Jens, 2013, In: Journal of Virology. 87, 3, p. 1385-99 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein
Keck, Z., Wang, W., Wang, Y., Lau, P., Carlsen, T. H. R., Prentø, Jannick, Xia, J., Patel, A. H., Bukh, Jens & Foung, S. K. H., 2013, In: Journal of Virology. 87, 1, p. 37-51 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutralization resistance of hepatitis C virus can be overcome by recombinant human monoclonal antibodies
Pedersen, J. L., Carlsen, T. H. R., Prentø, Jannick, Ramirez, S., Jensen, T. B., Forns, X., Alter, H., Foung, S. K. H., Law, M., Gottwein, Judith Margarete, Weis, Nina & Bukh, Jens, 2013, In: Hepatology. 58, 5, p. 1587-1597 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutralizing antibodies in patients with chronic hepatitis C, genotype 1, against a panel of genotype 1 culture viruses
Pedersen, J., Jensen, T. B., Carlsen, T. H. R., Schønning, Kristian, Christensen, P. B., Laursen, A. L., Krarup, H., Bukh, Jens & Weis, Nina, 2013, In: P L o S One. 8, 5, 16 p., e62674.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system
Li, Y., Ramirez, S., Jensen, S. B., Purcell, R. H., Gottwein, Judith Margarete & Bukh, Jens, 27 Nov 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 48, p. 19757-62 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells
Saeed, M., Scheel, Troels Kasper Høyer, Gottwein, Judith Margarete, Marukian, S., Dustin, L. B., Bukh, Jens & Rice, C. M., Oct 2012, In: Antimicrobial Agents and Chemotherapy. 56, 10, p. 5365-73 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Negative HCV-RNA 2 weeks after initiation of treatment predicts sustained virological response to pegylated interferon alfa-2a and ribavirin in patients with chronic hepatitis C
Christensen, P. B., Krarup, H. B., Laursen, A. L., Madsen, P. H., Pedersen, C., Schlichting, P., Orholm, M., Larsen, H. R., Bukh, Jens & Krogsgaard, K., Sep 2012, In: Scandinavian Journal of Gastroenterology. 47, 8-9, p. 1115-1119Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Animal models for the study of hepatitis C virus infection and related liver disease
Bukh, Jens, May 2012, In: Gastroenterology. 142, 6, p. 1279-1287.e3 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
Giang, E., Dorner, M., Prentø, Jannick, Dreux, M., Evans, M. J., Bukh, Jens, Rice, C. M., Ploss, A., Burton, D. R. & Law, M., 17 Apr 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6205-10 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus epitope exposure and neutralization by antibodies is affected by time and temperature
Sabo, M. C., Luca, V. C., Ray, S. C., Bukh, Jens, Fremont, D. H. & Diamond, M. S., 20 Jan 2012, In: Virology. 422, 2, p. 174-84 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems
Scheel, Troels Kasper Høyer, Prentø, Jannick, Carlsen, T. H. R., Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, 2012, In: P L o S Pathogens. 8, 5, p. 1-16 17 p., e1002696.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate
Keck, Z., Xia, J., Wang, Y., Wang, W., Krey, T., Prentø, Jannick, Carlsen, T., Li, A. Y., Patel, A. H., Lemon, S. M., Bukh, Jens, Rey, F. A. & Foung, S. K. H., 2012, In: P L o S Pathogens. 8, 4, 21 p., e1002653.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains
Li, Y., Ramirez, S., Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Mikkelsen, L., Purcell, R. H. & Bukh, Jens, 2012, In: Proceedings of the National Academy of Sciences USA (PNAS). 109, 18, p. E1101-E1110 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Correlates of spontaneous clearance of hepatitis C virus in a Danish human immunodeficiency virus type 1 cohort
Clausen, L. N., Weis, Nina, Schønning, Kristian, Fenger, M., Krarup, H., Bukh, Jens & Benfield, Thomas, Oct 2011, In: Scandinavian Journal of Infectious Diseases. 43, 10, p. 798-803 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FLAVIVIRDAE
Bukh, Jens, Oct 2011, Virus Taxonomy: 9. report of the International Committee on Taxonomy of Viruses. Mq King, A., Lefkowitz, E., Adams, M. J. & Carstens, E. B. (eds.). 1 ed. Elsevier, p. 1003-1020 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Efficient Culture Adaptation of Hepatitis C Virus Recombinants with Genotype-Specific Core-NS2 by Using Previously Identified Mutations
Scheel, Troels Kasper Høyer, Gottwein, J. M., Carlsen, T. H. R., Li, Y., Jensen, T. B., Spengler, U., Weis, Nina & Bukh, Jens, Mar 2011, In: Journal of Virology. 85, 6, p. 2891-2906 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enhanced and sustained CD8+ T cell responses with an adenoviral vector-based hepatitis C virus vaccine encoding NS3 linked to the MHC class II chaperone protein invariant chain
Mikkelsen, M., Holst, Peter Johannes, Bukh, Jens, Thomsen, Allan Randrup & Christensen, Jan Pravsgaard, 15 Feb 2011, In: Journal of Immunology. 186, 4, p. 2355-64 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effectiveness of treatment with pegylated interferon and ribavirin in an unselected population of patients with chronic hepatitis C: a Danish nationwide cohort study
Hansen, N., Obel, Niels, Christensen, P., Kjær, M. S., Laursen, A. L., Krarup, H. B., Møller, A., Schliehting, P., Bukh, Jens, Weis, Nina, Danish Database for Hepatitis B and C (DANHEP)- group, D. D. F. H. B. A. C. (. G. & Nørregaard, Peter, 1 Jan 2011, In: B M C Infectious Diseases. 11, p. 177 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A
Gottwein, J. M., Jensen, T. B., Mathiesen, C. K., Meuleman, P., Serre, S. B. N., Lademann, J. B., Ghanem, L., Scheel, Troels Kasper Høyer, Leroux-Roels, G. & Bukh, Jens, 2011, In: Journal of Virology. 85, 17, p. 8913-28 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses
Gottwein, J. M., Scheel, Troels Kasper Høyer, Jensen, T. B., Ghanem, L. & Bukh, Jens, 2011, In: Gastroenterology Today. 141, 3, p. 1067-1079 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C homolog in dogs with respiratory illness
Bukh, Jens, 2011, In: PNAS Early Edition. 108, 31, p. 12563-4 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus expressing flag-tagged envelope protein 2 has unaltered infectivity and density, is specifically neutralized by flag antibodies and can be purified by affinity chromatography
Prentø, Jannick & Bukh, Jens, 2011, In: Virology. 409, 2, p. 148-55Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization
Prentø, Jannick, Jensen, T. B., Meuleman, P., Serre, S., Scheel, Troels Kasper Høyer, Leroux-Roels, G., Gottwein, J. & Bukh, Jens, 2011, In: Journal of Virology. 85, 5, p. 2224-34 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus
Meuleman, P., Bukh, Jens, Verhoye, L., Farhoudi, A., Vanwolleghem, T., Wang, R. Y., Desombere, I., Alter, H., Purcell, R. H. & Leroux-Roels, G., 2011, In: Hepatology. 53, 3, p. 755-62Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort
Clausen, L. N., Weis, Nina, Astvad, K., Schønning, Kristian, Fenger, M., Krarup, H., Bukh, Jens & Benfield, Thomas, 2011, In: Journal of Viral Hepatitis. 18, 4, p. e66-e74 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR
Li, Y., Gottwein, J., Scheel, Troels Kasper Høyer, Jensen, T. B. & Bukh, Jens, 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 12, p. 4991-4996Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutralizing antibodies to hepatitis C virus in perinatally infected children followed up prospectively
Meunier, J., Bukh, Jens, Diaz, G., Tovo, P., Casadei, A. M., Quinti, I., Iorio, R., Emerson, S., Purcell, R. H. & Farci, P., 2011, In: Journal of Infectious Diseases. 204, 11, p. 1741-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step
Sabo, M. C., Luca, V. C., Prentø, Jannick, Hopcraft, S. E., Blight, K. J., Yi, M., Lemon, S. M., Ball, J. K., Bukh, Jens, Evans, M. J., Fremont, D. H. & Diamond, M. S., 2011, In: Journal of Virology. 85, 14, p. 7005-19 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Non-genotype-specific role of the hepatitis C virus 5' untranslated region in virus production and in inhibition by interferon
Li, Y., Ramirez, S., Gottwein, J. M. & Bukh, Jens, 2011, In: Virology: Research and Treatment. 421, 2, p. 222-34 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-a
Scheel, Troels Kasper Høyer, Gottwein, J. M., Mikkelsen, L. S., Jensen, T. B. & Bukh, Jens, 2011, In: Gastroenterology Today. 140, 3, p. 1032-42 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae
Stapleton, J. T., Foung, S., Muerhoff, A. S., Bukh, Jens & Simmonds, P., 2011, In: Journal of General Virology. 92, Pt 2, p. 233-46 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transmission of clonal hepatitis C virus genomes reveals the dominant but transitory role of CD8¿ T cells in early viral evolution
Callendret, B., Bukh, Jens, Eccleston, H. B., Heksch, R., Hasselschwert, D. L., Purcell, R. H., Hughes, A. L. & Walker, C. M., 2011, In: Journal of Virology. 85, 22, p. 11833-45 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus
Meunier, J., Gottwein, J. M., Houghton, M., Russell, R. S., Emerson, S. U., Bukh, Jens & Purcell, R. H., 2011, In: Journal of Infectious Diseases. 204, 8, p. 1186-90 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models
Bukh, Jens, Meuleman, P., Tellier, R., Engle, R. E., Feinstone, S. M., Eder, G., Satterfield, W. C., Govindarajan, S., Krawczynski, K., Miller, R. H., Leroux-Roels, G. & Purcell, R. H., 1 May 2010, In: Journal of Infectious Diseases. 201, 9, p. 1381-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular and epidemiological profiles of hepatitis C virus genotype 4 in Denmark
Eriksen, M. B., Jørgensen, L. B., Krarup, H., Laursen, A. L., Christensen, P. B., Møller, A., Schlichting, P., Kuiken, C., Bukh, Jens, Weis, N. & DANHEP Group, D. G., 2010, In: Journal of Medical Virology. 82, 11, p. 1869-1877 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular evolution of GB virus B hepatitis virus during acute resolving and persistent infections in experimentally infected tamarins
Takikawa, S., Engle, R. E., Faulk, K. N., Emerson, S. U., Purcell, R. H. & Bukh, Jens, 2010, In: Journal of General Virology. 91, Pt 3, p. 727-33 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies
Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Callendret, B., Li, Y., Eccleston, H. B., Engle, R. E., Govindarajan, S., Satterfield, W., Purcell, R. H., Walker, C. M. & Bukh, Jens, 2010, In: Journal of Virology. 84, 10, p. 5277-93 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
DELETION OF HYPERVARIABLE REGION 1 (HVR1) OF E2 FROM HCV GENOTYPES 1-6 HAS DIFFERENTIAL EFFECT ON INFECTIVITY IN VITRO AND CAUSES INCREASED SUSCEPTIBILITY TO NEUTRALIZATION
Prentø, Jannick, Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Jensen, T. B., Serre, S. & Bukh, Jens, 2009, In: Journal of Hepatology. 50, p. S34-S34Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs
Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Jensen, T. B., Lademann, J. B., Prentø, Jannick, Knudsen, M. L., Hoegh, A. M. & Bukh, Jens, 2009, In: Hepatology. 49, 2, p. 364-77 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MONOCISTRONIC HEPATITIS C REPORTER VIRUS RECOMBINANTS OF ALL MAJOR GENOTYPES EXPRESSING ENHANCED GREEN FLUORESCENT PROTEIN TAGGED NS5A PROTEIN
Gottwein, Judith Margarete, Lademann, J. B., Scheel, Troels Kasper Høyer, Jensen, T. B., Prentø, Jannick & Bukh, Jens, 2009, In: Journal of Hepatology. 50, p. S33-S33Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutational analysis of the hepatitis C virus E1 glycoprotein in retroviral pseudoparticles and cell-culture-derived H77/JFH1 chimeric infectious virus particles
Russell, R. S., Kawaguchi, K., Meunier, J., Takikawa, S., Faulk, K., Bukh, Jens, Purcell, R. H. & Emerson, S. U., 2009, In: Journal of Viral Hepatitis. 16, 9, p. 621-32 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Predictors of antiviral treatment initiation in hepatitis C virus-infected patients: a Danish cohort study
Hansen, N., Obel, N., Christensen, P. B., Krarup, H., Laursen, A. L., Clausen, M. R., Lunding, S., Møller, A., Schlichting, P., Kromann-Andersen, H., Bukh, J., Weis, N., Hansen, N., Obel, N., Christensen, P. B., Krarup, H., Laursen, A. L., Clausen, M. R., Lunding, S., Møller, A. & 4 others, , 2009, In: Journal of Viral Hepatitis. 16, 9, p. 659-65 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus
Russell, R. S., Meunier, J., Takikawa, S., Faulk, K., Engle, R. E., Bukh, Jens, Purcell, R. H. & Emerson, S. U., 18 Mar 2008, In: PNAS Early Edition. 105, 11, p. 4370-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems.
Gottwein, Judith Margarete & Bukh, Jens, 2008, In: Advances in Virus Research. 71, p. 51-133 82 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization
Scheel, Troels Kasper Høyer, Gottwein, Judith Margarete, Jensen, T. B., Prentø, Jannick, Høegh, A. M., Alter, H. J., Eugen-Olsen, J. & Bukh, Jens, 2008, In: Proceedings of the National Academy of Science of the United States of America. 105, 3, p. 997-1002 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of a TaqMan assay for the six major genotypes of hepatitis C virus: Comparison with commercial assays
Engle, R. E., Russell, R. S., Purcell, R. H. & Bukh, Jens, 2008, In: Journal of Medical Virology. 80, 1, p. 72-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C: the virus and studies of its lifecycle in cell culture systems
Bukh, Jens, Gottwein, J. M., Scheel, T. K. & Forns, X., 2008, 100 Key Questions on Hepatitis C. Forns, X. (ed.). 1 ed. Barcelona, Spain: Permanyer Publications, Vol. 1. p. 1-15 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Highly Efficient JFH1-Based Cell-Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing-Antibody Treatment to Control Infection
Jensen, T. B., Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Høgh, A. M., Eugen-Olsen, J. & Bukh, Jens, 2008, In: Journal of Infectious Diseases. 198, 12, p. 1756-1765 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Immunity against the GBV-B hepatitis virus in tamarins can prevent productive infection following rechallenge and is long-lived
Bukh, Jens, Engle, R. E., Govindarajan, S. & Purcell, R. H., 2008, In: Journal of Medical Virology. 80, 1, p. 87-94 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intragenotypic JFH1 based recombinant hepatitis C virus produces high levels of infectious particles but causes increased cell death.
Mateu, G., Donis, R. O., Wakita, T., Bukh, Jens & Grakoui, A., 2008, In: Virology. 376, 2, p. 397-407 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Isolation and characterization of broadly neutralizing human monoclonal antibodies to the e1 glycoprotein of hepatitis C virus
Meunier, J., Russell, R. S., Goossens, V., Priem, S., Walther, H., Depla, E., Union, A., Faulk, K. N., Bukh, Jens, Emerson, S. U. & Purcell, R. E., 2008, In: Journal of Virology. 82, 2, p. 966-73 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain.
Vanwolleghem, T., Bukh, Jens, Meuleman, P., Desombere, I., Meunier, J., Alter, H., Purcell, R. H. & Leroux-Roels, G., 2008, In: Hepatology. 47, 6, p. 1846-1855 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Previously infected chimpanzees are not consistently protected against reinfection or persistent infection after reexposure to the identical hepatitis C virus strain.
Bukh, Jens, Thimme, R., Meunier, J., Faulk, K., Spangenberg, H. C., Chang, K., Satterfield, W., Chisari, F. V. & Purcell, R. H., 2008, In: Journal of Virology. 82, 16, p. 8183-95 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Current status of a hepatitis C vaccine: encouraging results but significant challenges ahead
Mikkelsen, M. & Bukh, Jens, 2007, In: Current Infectious Disease Reports. 9, 2, p. 94-101 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus host cell interactions uncovered
Gottwein, J. & Bukh, Jens, 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 33, p. 13215-6Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vivo study of the HC-TN strain of hepatitis C virus recovered from a patient with fulminant hepatitis: RNA transcripts of a molecular clone (pHC-TN) are infectious in chimpanzees but not in Huh7.5 cells
Sakai, A., Takikawa, S., Thimme, R., Meunier, J. C., Spangenberg, H. C., Govindarajan, S., Farci, P., Emerson, S. U., Chisari, F. V., Purcell, R. H. & Bukh, Jens, 2007, In: Journal of Virology. 81, 13, p. 7208-7219 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Monitoring of hepatitis C virus quasispecies in chronic infection by matrix-assisted laser desorption ionization-time of flight mass spectrometry mutation detection
Yea, C., Bukh, Jens, Ayers, M., Roberts, E., Krajden, M. & Tellier, R., 2007, In: Journal of Clinical Microbiology. 45, 3, p. 1053-1057 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a/2a (S52/JFH1) viruses
Gottwein, J. M., Scheel, Troels Kasper Høyer, Hoegh, A. M., Lademann, J. B., Eugen-Olsen, J., Lisby, G. & Bukh, Jens, 2007, In: Gastroenterology. 133, 5, p. 1614-26 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
A comprehensive system for consistent numbering of HCV sequences, proteins and epitopes.
Kuiken, C., Combet, C., Bukh, Jens, Shin-I, T., Deleage, G., Mizokami, M., Richardson, R., Sablon, E., Yusim, K., Pawlotsky, J., Simmonds, P. & Los Alamos HIV Database Group, L. A. H. D. G., 2006, In: Hepatology. 44, 5, p. 1355-61 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A milestone for hepatitis C virus research: a virus generated in cell culture is fully viable in vivo.
Bukh, Jens & Purcell, R. H., 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 10, p. 3500-1 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional analyses of GB virus B p13 protein: Development of a recombinant GB virus B hepatitis virus with a p7 protein
Takikawa, S., Engle, R. E., Emerson, S. U., Purcell, R. H., St Claire, M. & Bukh, Jens, 2006, In: Proceedings of the National Academy of Science of the United States of America. 103, 9, p. 3345-50 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C hos hiv-inficerede patienter
Bukh, Jens & Nielsen, J. O., 2006, In: Ugeskrift for læger. 168, 42, p. 3599-Research output: Contribution to journal › Journal article › Research › peer-review
ID: 12437
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Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies
Research output: Contribution to journal › Review › Research › peer-review
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Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies
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Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry
Research output: Contribution to journal › Review › Research › peer-review
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