Thomas Litman

Thomas Litman

Professor

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    ORCID: 0000-0002-6068-901X

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    1. Published

      Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity

      Litman, Thomas, Zeuthen, Thomas, Skovsgaard, T. & Stein, W. D., 1997, In: BBA General Subjects. vol. 1361, p. 169-176

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Use of peptide antibodies to probe for the mitoxantrone resistance-associated protein MXR/BCRP/ABCP/ABCG2

      Litman, Thomas, Jensen, U., Hansen, Alastair, Covitz, K., Zhan, Z., Fetsch, P., Abati, A., Hansen, Paul Robert, Horn, T., Skovsgaard, T. & Bates, S. E., 20 Sep 2002, In: BBA General Subjects. 1565, 1, p. 6-16 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Pumping of drugs by P-glycoprotein: a two-step process?

      Litman, Thomas, Skovsgaard, T. & Stein, W. D., 2003, In: Pharmacol Exp Ther.. 307(3), p. 846-853

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Lipid composition of sensitive and multidrug resistant Ehrlich ascites tumour cells

      Litman, Thomas, Nielsen, D., Skovsgaard, T. & Bukhave, K., 1995, In: Cellular Pharmacology. Vol 2, p. 9-14

      Research output: Contribution to journal › Journal article › Research

    5. Published

      From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance

      Litman, Thomas, Druley, T. E., Stein, W. D. & Bates, S. E., 2001, In: Cell Mol Life Sci.. 931-959, p. 58

      Research output: Contribution to journal › Journal article › Research

    6. Published

      From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance

      Litman, Thomas, Druley, T. E., Stein, W. D. & Bates, S. E., Jun 2001, In: Cellular and molecular life sciences : CMLS. 58, 7, p. 931-59 29 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Ammonia and urea permeability of mammalian aquaporins

      Litman, Thomas, Søgaard, R. & Zeuthen, Thomas, 2009, In: Handbook of Experimental Pharmacology. 190, p. 327-58 31 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Obtaining estimates for the ages of all the protein-coding genes and most of the ontology-identified noncoding genes of the human genome, assigned to 19 phylostrata

      Litman, Thomas & Stein, W. D., 2019, In: Seminars in Oncology. 46, 1, p. 3-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity

      Litman, Thomas, Zeuthen, Thomas, Skovsgaard, T. & Stein, W. D., 1997, In: BBA General Subjects. 1361, 2, p. 159-168

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      pH regulation in sensitive and multidrug resistant Ehrlich ascites tumor cells

      Litman, Thomas, Pedersen, S. F., Kramhøft, B., Skovsgaard, T. & Hoffmann, E. K., 1998, In: Cellular Physiology and Biochemistry. 8, 3, p. 138-50 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Pumping of drugs by P-glycoprotein: a two-step process?

      Litman, Thomas, Skovsgaard, T. & Stein, W. D., Dec 2003, In: Journal of Pharmacology and Experimental Therapeutics. 307, 3, p. 846-53 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      pH regulation in sensitive and multidrug resistant Ehrlich ascites tumor cells

      Litman, Thomas, Pedersen, Stine Helene Falsig, Kramhøft, B., Skovsgaard, T. & Hoffmann, E. K., 1998, In: Cell. Physiol. Biochem.. 8, p. 138-150

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      ATPase activity of P-glycoprotein related to emergence of drug resistance in Ehrlich ascites tumor cell lines

      Litman, Thomas, Nielsen, D., Skovsgaard, T., Zeuthen, Thomas & Stein, W. D., 1997, In: BBA General Subjects. 1361, 2, p. 147-158

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      The multidrug resistant phenotype - A comparative study

      Litman, Thomas, 1 Dec 1997, In: Ugeskrift for Laeger. 159, 6, p. 771-772 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)

      Litman, Thomas, Brangi, M., Hudson, E., Fetsch, P., Abati, A., Ross, D. D., Miyake, K., Resau, J. H. & Bates, S. E., Jun 2000, In: Journal of Cell Science. 113 ( Pt 11), p. 2011-21 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

      Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 5 Feb 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 3, p. 1683-8 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Histone deacetylase inhibitor-mediated cell death is distinct from its global effect on chromatin

      Luchenko, V. L., Litman, Thomas, Chakraborty, A. R., Heffner, A., Devor, C., Wilkerson, J., Stein, W., Robey, R. W., Bangiolo, L., Levens, D. & Bates, S. E., 2014, In: Molecular Oncology. 8, 8, p. 1379-1392 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Global microRNA expression profiling of high-risk ER+ breast cancers from patients receiving adjuvant tamoxifen mono-therapy: a DBCG study

      Lyng, M. B., Lænkholm, A. V., Søkilde, R., Gravgaard, K. H., Litman, Thomas & Ditzel, H., 2012, In: PloS one. 7, 5, p. e36170

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Generation of an activating ZN(2+) switch in the dopamine transporter: Mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

      Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 2002, In: Proceedings of the National Academy of Science of the United States of America. vol. 99(3), p. 1683-8

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Gene expression analysis during progression of malignant meningioma compared to benign meningioma

      Maier, A. D., Meddis, Alessandra, Mirian, C., Haslund-Vinding, Jeppe Lohfert, Bartek, J., Krog, S. M., Nguyen, T. U. P., Areškevičiūtė, A., Melchior, L. C., Heegaard, Steffen, Kristensen, Bjarne Winther, Munch, Tina Nørgaard, Fugleholm, Kåre, Ziebell, M., Raleigh, D. R., Poulsen, F. R., Gerds, Thomas Alexander, Litman, Thomas, Scheie, David & Mathiesen, Tiit Illimar, 2023, In: Journal of Neurosurgery. 138, 5, p. 1-11 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Validation of a diagnostic miRNA classifier in cutaneous T-cell lymphomas

      Marstrand, T., Ahler, C. B., Ralfkiaer, U., Clemmensen, A., Kopp, K. L., Sibbesen, N. A., Krejsgaard, T., Litman, Thomas, Wasik, M. A., Bonefeld, Charlotte Menne, Grønbæk, Kirsten, Gjerdum, L. M. R., Gniadecki, R., Ralfkiaer, E., Geisler, Carsten, Woetmann, Anders , Røpke, M. A., Glue, C., Skov, Lone & Ødum, Niels, 2014, In: Leukemia and Lymphoma. 55, 4, p. 957-958 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Distinct molecular signatures of mild extrinsic and intrinsic atopic dermatitis

      Martel, B. C., Litman, Thomas, Hald, A., Norsgaard, H., Lovato, P., Dyring-Andersen, Beatrice, Skov, Lone, Thestrup-Pedersen, K., Skov, Søren, Skak, K. & Poulsen, Lars K., Jun 2016, In: Experimental Dermatology Online. 25, 6, p. 453-459 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Diagnostic and prognostic signatures from the small non-coding RNA transcriptome in prostate cancer

      Martens-Uzunova, E. S., Jalava, S. E., Dits, N. F., van Leenders, G. J. L. H., Møller, S., Trapman, J., Bangma, C. H., Litman, Thomas, Visakorpi, T. & Jenster, G., 18 Jul 2011, In: Oncogene. 31, 8, p. 978-991 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes

      Miyake, K., Mickley, L., Litman, Thomas, Zhan, Z., Robey, R., Cristensen, B., Brangi, M., Greenberger, L., Dean, M., Fojo, T. & Bates, S. E., 1 Jan 1999, In: Cancer Research. 59, 1, p. 8-13 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Repeated monthly epicutaneous challenges with diphenylcyclopropenone result in a clinically reproducible level of contact allergy in de novo sensitized individuals

      Mose, K. F., Andersen, F., Skov, Lone, Røpke, M. A., Litman, Thomas, Friedmann, P. S. & Andersen, K. E., Apr 2017, In: British Journal of Dermatology. 176, 4, p. 1095-1097

      Research output: Contribution to journal › Letter › Research › peer-review

    26. Published

      The gene expression and immunohistochemical time-course of diphenylcyclopropenone-induced contact allergy in healthy humans following repeated epicutaneous challenges

      Mose, K. F., Burton, M., Thomassen, M., Andersen, F., Kruse, T. A., Tan, Q., Skov, Lone, Ropke, M. A., Litman, Thomas, Clemmensen, O., Kristensen, B. W., Friedmann, P. S. & Andersen, K. E., Oct 2017, In: Experimental Dermatology. 26, 10, p. 926-933

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Elevated NK-cell transcriptional signature and dysbalance of resting and activated NK cells in atopic dermatitis

      Möbus, L. & TREATgermany Study Group, T. S. G., 2021, In: Journal of Allergy and Clinical Immunology. 147, 5, p. 1959-1965.e2

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      LAG3 and TIGIT Expression on Tumor-Infiltrating Lymphocytes in Cutaneous Melanoma

      Naimy, S., Bzorek, M., Eriksen, J. O., Løvendorf, Marianne Bengtson, Litman, Thomas, Dyring-Andersen, Beatrice & Gjerdrum, Lise Mette Rahbek, 2024, In: Dermatology. 240, p. 156-163

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. E-pub ahead of print

      Comparative quantitative proteomic analysis of melanoma subtypes, nevus-associated melanoma, and corresponding nevi

      Naimy, S., Sølberg, J. B. K., Kuczek, D. E., Løvendorf, Marianne Bengtson, Bzorek, M., Litman, Thomas, Mund, Andreas, Gjerdrum, Lise Mette Rahbek, Clark, R. A., Mann, Matthias & Dyring-Andersen, Beatrice, 5 Jan 2024, (E-pub ahead of print) In: The Journal of Investigative Dermatology.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Inhibition of succinate dehydrogenase activity impairs human T cell activation and function: [Publisher correction]

      Nastasi, C., Willerlev-Olsen, A., Dalhoff, K., Ford, Shayne Lavondua, Gadsbøll, A. S. Ø., Buus, Terkild Brink, Gluud, Maria, Danielsen, M., Litman, Thomas, Bonefeld, Charlotte Menne, Geisler, Carsten, Ødum, Niels & Woetmann, Anders , 2021, In: Scientific Reports. 11, 1, 1458.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Structural determinants underlying permeant discrimination of the Cx43 hemichannel

      Nielsen, B. S., Zonta, F., Farkas, T., Litman, Thomas, Nielsen, Morten Schak & MacAulay, Nanna, 2019, In: Journal of Biological Chemistry. 294, 45, p. 16789-16803 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Characterisation of non-P-glycoprotein multidrug-resistant Ehrlich ascites tumour cells selected for resistance to mitoxantrone

      Nielsen, D., Eriksen, J., Maare, C., Litman, Thomas, Kjaersgaard, E., Plesner, T., Friche, E. & Skovsgaard, T., 1 Aug 2000, In: Biochemical Pharmacology. 60, 3, p. 363-70 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Expression of P-glycoprotein and multidrug resistance associated protein in Ehrlich ascites tumor cells after fractionated irradiation

      Nielsen, D., Maare, C., Eriksen, J., Litman, Thomas & Skovsgaard, T., 15 Nov 2001, In: International Journal of Radiation Oncology, Biology, Physics. 51, 4, p. 1050-7 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Characterisation of multidrug-resistant Ehrlich ascites tumour cells selected in vivo for resistance to etoposide

      Nielsen, D., Maare, C., Eriksen, J., Litman, Thomas, Friche, E. & Skovsgaard, T., 1 Aug 2000, In: Biochemical Pharmacology. 60, 3, p. 353-61 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Expression of P-glycoprotein and multidrug resistance associated protein in Ehrlich ascites tumor cells after fractionated irradiation

      Nielsen, D., Maare, C., Eriksen, J., Litman, Thomas & Skovsgaard, T., 2001, In: Int J Radiat Oncol Biol Phys. 51, p. 1050-1057

      Research output: Contribution to journal › Journal article › Research

    36. Published

      Characterisation of non-P-glycoprotein multidrug-resistant Ehrlich ascites tumour cells selected for resistance to mitoxantrone

      Nielsen, D., Eriksen, J., Maare, C., Litman, Thomas, Kjaersgaard, E., Plesner, T., Friche, E. & Skovsgaard, T., 2000, In: Biochem Pharmacol.. 363-370, p. 60

      Research output: Contribution to journal › Journal article › Research

    37. E-pub ahead of print

      Stage-related increase in PIM2 expression in mycosis fungoides

      Nielsen, M. H., Nielsen, Pia Rude, Bzorek, M., Eriksen, J. O., Wehkamp, U., Lindahl, L. M., Woetmann, Anders , Ødum, Niels, Litman, Thomas & Gjerdrum, Lise Mette Rahbek, 2024, (E-pub ahead of print) In: APMIS. 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Diagnostic Two-Gene Classifier in Early-Stage Mycosis Fungoides: A Retrospective Multicenter Study

      Nielsen, Pia Rude, Eriksen, J. O., Lindahl, L. M., Wehkamp, U., Bzorek, M., Andersen, G., Woetmann, Anders , Iversen, L., Ødum, Niels, Litman, Thomas & Gjerdrum, Lise Mette Rahbek, 2021, In: Journal of Investigative Dermatology. 141, 1, p. 213-217.e5

      Research output: Contribution to journal › Letter › Research › peer-review

    39. Published

      Role of B-cells in mycosis fungoides

      Nielsen, Pia Rude, Eriksen, J. O., Sørensen, M. D., Wehkamp, U., Lindahl, L. M., Bzorek, M., Iversen, L., Woetmann, Anders , Ødum, Niels, Litman, Thomas & Gjerdrum, Lise Mette Rahbek, 2021, In: Acta Dermato-Venereologica. 101, 3, adv00413.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. The molecular signature of chronic prurigo

      Ohanyan, T., Litman, Thomas, Hawro, T., Schoepke, N., Koopmann, W., Maurer, M. & Metz, M., 2018, In: Experimental Dermatology. 27, 3, p. E79-E79 P180.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    41. Published

      Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis

      Olesen, C. M., Clausen, M. L., Agner, Tove, Asplund, M., Rasmussen, Linett, Yüksel, Y. T., Andersen, P. S., Litman, Thomas, Hansen, Anders Johannes & Barnes, Christopher James, 2022, In: Acta Dermato-Venereologica. 102, 7 p., adv00817.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells

      Ozvegy, C., Litman, Thomas, Szakács, G., Nagy, Z., Bates, S., Váradi, A. & Sarkadi, B., 6 Jul 2001, In: Biochemical and Biophysical Research Communications. 285, 1, p. 111-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells

      Ozvegy, C., Litman, Thomas, Szakacs, G., Nagy, Z., Bates, S., Varadi, A. & Sarkadi, B., 2001, In: Biochem. Biophys. Res. Commun.. 285, p. 111-117

      Research output: Contribution to journal › Journal article › Research

    44. Published

      Adrenocortical cancer: A molecularly complex disease where surgery matters

      Payabyab, E. C., Balasubramaniam, S., Edgerly, M., Velarde, M., Merino, M. J., Venkatesan, A. M., Leuva, H., Litman, Thomas, Bates, S. E. & Fojo, T., 15 Oct 2016, In: Clinical Cancer Research. 22, 20, p. 4989-5000 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Ablative fractional laser treatment reduces hedgehog pathway gene expression in murine basal cell carcinomas

      Pedersen, K. K., Granborg, J. R., Lerche, Catharina Margrethe, Litman, Thomas, Olesen, U. H. & Hædersdal, Merete, 2024, In: Lasers in Medical Science. 39, 1, 9 p., 55.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Topical Delivery of Hedgehog Inhibitors: Current Status and Perspectives

      Pedersen, K. K., Høyer-Hansen, M. H., Litman, Thomas, Hædersdal, Merete & Olesen, U. H., 2022, In: International Journal of Molecular Sciences. 23, 22, 14191.

      Research output: Contribution to journal › Review › Research › peer-review

    47. Published

      How the RNA isolation method can affect microRNA microarray results

      Podolska, A., Kaczkowski, B., Litman, Thomas, Fredholm, Merete & Cirera, Susanna, 2011, In: Acta Biochimica Polonica. 58, 4, p. 535-540 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Downregulation of taurine uptake in multidrug resistant Ehrlich ascites tumor cells

      Poulsen, K. A., Litman, Thomas, Eriksen, J., Mollerup, J. & Lambert, Ian Henry, Jun 2002, In: Amino Acids. 22, 4, p. 333-50 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Downregulation of taurine uptake in multidrug resistant Ehrlich ascites tumor cells

      Poulsen, K. A., Litman, Thomas, Eriksen, J., Mollerup, J. & Lambert, Ian Henry, 2002, In: Amino Acids. 22, p. 333-350

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)

      Ralfkiaer, U., Hagedorn, P., Bangsgaard, N., Løvendorf, M. B., Ahler, C. B., Svensson, L., Kopp, K. L., Vennegaard, M. T., Lauenborg, B., Zibert, J. R., Krejsgaard, T., Bonefeld, C. M., Søkilde, R., Gjerdrum, L. M., Labuda, T., Mathiesen, A-M., Grønbaek, K., Wasik, M. A., Sokolowska-Wojdylo, M., Queille-Roussel, C. & 9 others, Gniadecki, R., Ralfkiaer, E., Geisler, Carsten, Litman, Thomas, Woetmann, Anders , Glue, C., Røpke, M. A., Skov, Lone & Ødum, Niels, 2011, In: Blood. 118, 22, p. 5891-5900 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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