Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic dermatitis
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Dokumenter
- Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic dermatitis_(accepted_version)
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The skin is our interface with the outside world and consequently it is exposed to a wide range of microbes and allergens. Recent studies have indicated that allergen-specific skin-resident memory T (TRM) cells play a role in allergic contact dermatitis (ACD). However, the composition and dynamics of the epidermal T cell subsets during ACD are not known. Here we show that exposure of the skin to the experimental contact allergen 1-fluoro-2,4-dinitrobenzene (DNFB) results in a displacement of the normally occurring dendritic epidermal T cells (DETC) concomitant with an accumulation of epidermal CD8+CD69+CD103+ TRM cells in mice. By studying knock-out mice, we provide evidence that CD8+ T cells are required for the displacement of the DETC and furthermore, that DETC are not required for recruitment of CD8+ TRM cells to the epidermis following allergen exposure. We demonstrate that the magnitude of the allergic reaction correlates with the number of CD8+ epidermal TRM cells that again correlates with allergen dose and number of allergen exposures. Finally, in an attempt to elucidate why CD8+ epidermal TRM cells persist in the epidermis, we show that CD8+ epidermal TRM cells have a higher proliferative capability and are bioenergetically more stable, displaying a higher spare respiratory capacity than DETC.
Originalsprog | Engelsk |
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Tidsskrift | The Journal of Investigative Dermatology |
Vol/bind | 140 |
Udgave nummer | 4 |
Sider (fra-til) | 806-815.e5 |
ISSN | 0022-202X |
DOI | |
Status | Udgivet - 2020 |
Bibliografisk note
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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