OTULIN deficiency causes auto-inflammatory syndrome
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Rådgivning
Ubiquitin chains assembled via the N-terminal methionine (Met1 or linear ubiquitin), conjugated by the linear ubiquitin chain assembly complex (LUBAC), participate in NF-κΒ-dependent inflammatory signaling and immune responses. A recent report in Cell finds that OTULIN, a deubiquitinase that selectively cleaves Met1-linked ubiquitin chains, is essential for restraining inflammation in vivo.
Originalsprog | Engelsk |
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Tidsskrift | Cell Research |
Vol/bind | 26 |
Udgave nummer | 11 |
Sider (fra-til) | 1176-1177 |
Antal sider | 2 |
ISSN | 1001-0602 |
DOI | |
Status | Udgivet - nov. 2016 |
ID: 280717847