Met1-linked Ubiquitination in Immune Signalling
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Methionine 1-linked ubiquitin chains (Met1-Ub), or linear ubiquitin, has emerged as a central post-translational modification in innate immune signalling. Molecular machinery that assembles, senses and, more recently, disassembles Met1-Ub has been identified, and technical advances have enabled identification of physiological substrates for Met1-Ub in response to activation of innate immune receptors. These discoveries have significantly advanced our understanding of how non-degradative ubiquitin modifications control pro-inflammatory responses mediated by nuclear factor κB and mitogen-activated protein kinases. In this review, we will discuss the current data on Met1-Ub function and regulation, and will point to some of the questions that still remain unanswered. This article is protected by copyright. All rights reserved.
Originalsprog | Engelsk |
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Tidsskrift | F E B S Journal |
Vol/bind | 81 |
Udgave nummer | 19 |
Sider (fra-til) | 4337-50 |
Antal sider | 14 |
ISSN | 1742-464X |
DOI | |
Status | Udgivet - okt. 2014 |
ID: 119770895