Hepatitis C virus envelope protein dynamics and the link to hypervariable region 1
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Dokumenter
- Hepatitis C virus envelope protein dynamics and the link to hypervariable region 1
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Conformational dynamics of viral envelope proteins seem to be involved in mediating evasion from neutralizing antibodies (NAbs) by mechanisms that limit exposure of conserved protein motifs. For hepatitis C virus (HCV), molecular studies have only recently begun to unveil how such dynamics of the envelope protein heterodimer, E1/E2, are linked to viral entry and NAb evasion. Here, we review data suggesting that E1/E2 exists in an equilibrium between theoretical ‘open’ (NAb-sensitive) and ‘closed’ (NAb-resistant) conformational states. We describe how this equilibrium is influenced by viral sequence polymorphisms and that it is critically dependent on the N-terminal region of E2, termed hypervariable region 1 (HVR1). Finally, we discuss how it appears that the virus binding site for the HCV entry co-receptor CD81 is less available in ‘closed’ E1/E2 states and that NAb-resistant viruses require a more intricate entry pathway involving also the entry co-receptor, SR-BI.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Current Opinion in Virology |
Vol/bind | 50 |
Sider (fra-til) | 69-75 |
Antal sider | 7 |
ISSN | 1879-6257 |
DOI | |
Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:
This work was supported by a Novo Nordisk Foundation Distinguished lnvestigator - Bioscience and Basic Biomedicine grant (Grant number: NNF19OC0054518 ; JB), a Lundbeck Foundation Experiment grant (Grant number: R324-2019-1375 ; JP) and a Lundbeck Foundation Fellowship grant (Grant number: R335-2019-2052 ; JP).
Publisher Copyright:
© 2021 The Author(s)
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