Clinical and histological characteristics of mycosis fungoides and sézary syndrome: A retrospective, single-centre study of 43 patients from eastern Denmark
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Dokumenter
- Clinical and Histological Characteristics of Mycosis Fungoides and Sézary Syndrome: A Retrospective, Single-centre Study of 43 Patients from Eastern Denmark
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Diagnosis of mycosis fungoides and Sézary syndrome can be very challenging. Clinical and histopathologicadata for patients with mycosis fungoides and Sézary syndrome in Denmark are limited. A retrospective study was performed in Region Zealand, Denmark from 1990 to 2016. A total of 43 patients with mycosis fungoides or Sézary syndrome were identified during the period. At the time of diagnosis the patients’ mean age was 64.3 years and 74.5% had early-stage (≤IIA) disease. The mean time from onset of skin disease to diagnosis was 4.4 years. Surprisingly, 43% progressed to a higher disease stage, and risk of disease progression was higher for stage IB than IA (p = 0.01)All cases displayed some degree of epidermotropism and the infiltrates consisted of pleomorphic lymphocytes with a T-helper (CD4+/CD8–) phenotype. This study describes, for the first time, all aspects of clinical and histopathological findings in patients with mycosis fungoides and Sézary syndrome in a well-characterized Danish cohort.
Originalsprog | Engelsk |
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Tidsskrift | Acta Dermato-Venereologica |
Vol/bind | 99 |
Udgave nummer | 13 |
Sider (fra-til) | 1231-1236 |
Antal sider | 6 |
ISSN | 0001-5555 |
DOI | |
Status | Udgivet - 2019 |
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