Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
For any controlled human infection model (CHIM), a safe, standardized, and biologically relevant challenge inoculum is necessary. For hepatitis C virus (HCV) CHIM, we propose that human-derived high-titer inocula of several viral genotypes with extensive virologic, serologic, and molecular characterizations should be the most appropriate approach. These inocula should first be tested in human volunteers in a step-wise manner to ensure safety, reproducibility, and curability prior to using them for testing the efficacy of candidate vaccines.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Clinical Infectious Diseases |
| Vol/bind | 77 |
| Sider (fra-til) | S257-S261 |
| ISSN | 1058-4838 |
| DOI | |
| Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
Supplement sponsorship. This article appears as part of the supplement “Controlled Human Infection Model for HCV Vaccine Development,” sponsored by Toronto General Research Institute, United States National Institutes of Health, Johns Hopkins University, the Canadian Institutes of Health Research (CIHR), and the Canadian Network on Hepatitis C (CanHepC). CanHepC is funded by a joint initiative of CIHR (HPC-178912) and the Public Health Agency of Canada.
Publisher Copyright:
© 2023 Oxford University Press. All rights reserved.
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