A vaccine displaying a trimeric influenza-A HA stem protein on capsid-like particles elicits potent and long-lasting protection in mice
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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A vaccine displaying a trimeric influenza-A HA stem protein on capsid-like particles elicits potent and long-lasting protection in mice. / Thrane, Susan; Aves, Kara-Lee; Uddbäck, Ida E M; Janitzek, Christoph M; Han, Julianna; Yang, Yuhe R; Ward, Andrew B; Theander, Thor G; Nielsen, Morten A; Salanti, Ali; Thomsen, Allan R; Christensen, Jan P; Sander, Adam F.
I: Vaccines, Bind 8, Nr. 3, 389, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - A vaccine displaying a trimeric influenza-A HA stem protein on capsid-like particles elicits potent and long-lasting protection in mice
AU - Thrane, Susan
AU - Aves, Kara-Lee
AU - Uddbäck, Ida E M
AU - Janitzek, Christoph M
AU - Han, Julianna
AU - Yang, Yuhe R
AU - Ward, Andrew B
AU - Theander, Thor G
AU - Nielsen, Morten A
AU - Salanti, Ali
AU - Thomsen, Allan R
AU - Christensen, Jan P
AU - Sander, Adam F
PY - 2020
Y1 - 2020
N2 - Due to constant antigenic drift and shift, current influenza-A vaccines need to be redesigned and administered annually. A universal flu vaccine (UFV) that provides long-lasting protection against both seasonal and emerging pandemic influenza strains is thus urgently needed. The hemagglutinin (HA) stem antigen is a promising target for such a vaccine as it contains neutralizing epitopes, known to induce cross-protective IgG responses against a wide variety of influenza subtypes. In this study, we describe the development of a UFV candidate consisting of a HAstem trimer displayed on the surface of rigid capsid-like particles (CLP). Compared to soluble unconjugated HAstem trimer, the CLP-HAstem particles induced a more potent, long-lasting immune response and were able to protect mice against both homologous and heterologous H1N1 influenza challenge, even after a single dose.
AB - Due to constant antigenic drift and shift, current influenza-A vaccines need to be redesigned and administered annually. A universal flu vaccine (UFV) that provides long-lasting protection against both seasonal and emerging pandemic influenza strains is thus urgently needed. The hemagglutinin (HA) stem antigen is a promising target for such a vaccine as it contains neutralizing epitopes, known to induce cross-protective IgG responses against a wide variety of influenza subtypes. In this study, we describe the development of a UFV candidate consisting of a HAstem trimer displayed on the surface of rigid capsid-like particles (CLP). Compared to soluble unconjugated HAstem trimer, the CLP-HAstem particles induced a more potent, long-lasting immune response and were able to protect mice against both homologous and heterologous H1N1 influenza challenge, even after a single dose.
U2 - 10.3390/vaccines8030389
DO - 10.3390/vaccines8030389
M3 - Journal article
C2 - 32679905
VL - 8
JO - Vaccines
JF - Vaccines
SN - 2076-393X
IS - 3
M1 - 389
ER -
ID: 245194291