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Susheel Singh

Susheel Singh

Assistant professor

Member of:

  • GLURP team

Current research

  • Development of multi-stage (asexual and sexual) malaria vaccine candidate.
  • VLP technology as a vaccine delivery system.
  • Apply the VLP-based antigen delivery platform to produce combination malaria vaccine (using promising antigen targets from liver stage, blood stage and transmission blocking stage).
  • Use the VLP-based antigen delivery platform to produce combination vaccine against Japanese Encephalitis Virus (JEV) (using the Envelope protein from major prevalent genotypes and transmission blocking: mosGCTL-7, a C-type lectin protein which plays crucial role in JEV transmission).
  • Parasitic genotyping, production of antigens for immunization in small rodents and serological studies.
  • Developing robust and reliable bioassays for assessing the efficacy of vaccine clinical trials.

Primary fields of research

  • Infectious diseases
  • Vaccine development

Selected publications

  1. Published

    Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity

    Stone, W. J. R., Campo, J. J., Ouédraogo, A. L., Meerstein-Kessel, L., Morlais, I., Da, D., Cohuet, A., Nsango, S., Sutherland, C. J., van de Vegte-Bolmer, M., Siebelink-Stoter, R., van Gemert, G-J., Graumans, W., Lanke, K., Shandling, A. D., Pablo, J. V., Teng, A. A., Jones, S., de Jong, R. M., Fabra-García, A., Bradley, J., Roeffen, W., Lasonder, E., Gremo, G., Schwarzer, E., Janse, C. J., Singh, S. K., Theisen, M., Felgner, P., Marti, M., Drakeley, C., Sauerwein, R., Bousema, T. & Jore, M. M., 8 Feb 2018, In : Nature Communications. 9, 1, 14 p., 558.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Dynamics of anti-MSP3 and Pfs230 antibody responses and multiplicity of infection in asymptomatic children from southern Ghana

    Amoah, L. E., Acquah, F. K., Ayanful-Torgby, R., Oppong, A., Abankwa, J., Obboh, E. K., Singh, S. K. & Theisen, M., 5 Jan 2018, In : Parasites & Vectors. 11, 1, 9 p., 13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Expression, Purification and Characterization of GMZ2'.10C, a Complex Disulphide-Bonded Fusion Protein Vaccine Candidate against the Asexual and Sexual Life-Stages of the Malaria-Causing Plasmodium falciparum Parasite

    Mistarz, U. H., Singh, S. K., Nguyen, T. T. T. N., Roeffen, W., Yang, F., Lissau, C., Madsen, S. M., Vrang, A., Tiendrebeogo, R. W., Kana, I. H., Sauerwein, R. W., Theisen, M. & Rand, K. D., 1 Sep 2017, In : Pharmaceutical Research. 34, 9, p. 1970-1983 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A novel Pfs38 protein complex on the surface of Plasmodium falciparum blood-stage merozoites

    Paul, G., Deshmukh, A., Kaur, I., Rathore, S., Dabral, S., Panda, A., Singh, S. K., Mohmmed, A., Theisen, M. & Malhotra, P., 16 Feb 2017, In : Malaria Journal. 16, 1, 15 p., 79.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Naturally acquired antibodies target the glutamate-rich protein on intact merozoites and predict protection against febrile malaria

    Kana, I. H., Adu, B., Tiendrebeogo, R. W., Singh, S. K., Dodoo, D. & Theisen, M., 15 Feb 2017, In : The Journal of Infectious Diseases. 215, 4, p. 623-630 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Antibody responses to two new Lactococcus lactis-produced recombinant Pfs48/45 and Pfs230 proteins increase with age in malaria patients living in the Central Region of Ghana

    Acquah, F. K., Obboh, E. K., Asare, K., Boampong, J. N., Nuvor, S. V., Singh, S. K., Theisen, M., Williamson, K. C. & Amoah, L. E., 2017, In : Malaria Journal. 16, 11 p., 306.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Construct design, production, and characterization of Plasmodium falciparum 48/45 R0.6C subunit protein produced in Lactococcus lactis as candidate vaccine

    Singh, S. K., Roeffen, W., Mistarz, U. H., Chourasia, B. K., Yang, F., Rand, K. D., Sauerwein, R. W. & Theisen, M., 2017, In : Microbial Cell Factories. 16, 1, 11 p., 97.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published
  9. Published

    Natural antibody responses to Plasmodium falciparum MSP3 and GLURP(R0) antigens are associated with low parasite densities in malaria patients living in the Central Region of Ghana

    Amoah, L. E., Nuvor, S. V., Obboh, E. K., Acquah, F. K., Asare, K., Singh, S. K., Boampong, J. N., Theisen, M. & Williamson, K. C., 2017, In : Parasites and Vectors. 10, 1, 9 p., 395.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Synthetic TLR4 agonists enhance functional antibodies and CD4+ T-cell responses against the Plasmodium falciparum GMZ2.6C multi-stage vaccine antigen

    Baldwin, S. L., Roeffen, W., Singh, S. K., Tiendrebeogo, R. W., Christiansen, M., Beebe, E., Carter, D., Fox, C. B., Howard, R. F., Reed, S. G., Sauerwein, R. & Theisen, M., 27 Apr 2016, In : Vaccine. 34, 19, p. 2207-2215 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Controlled synthesis, bioimaging and toxicity assessments in strong red emitting Mn2+ doped NaYF4:Yb3+/Ho3+ nanophosphors

    Reddy, K. L., Rai, M., Prabhakar, N., Arppe, R., Rai, S. B., Singh, S. K., Rosenholm, J. M. & Krishnan, V., 2016, In : RSC Advances. 6, 59, p. 53698-53704 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    A Plasmodium falciparum 48/45 single epitope R0.6C subunit protein elicits high levels of transmission blocking antibodies

    Singh, S. K., Roeffen, W., Andersen, G., Bousema, T., Christiansen, M., Sauerwein, R. & Theisen, M., 15 Apr 2015, In : Vaccine. 33, 16, p. 1981-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Antibody-dependent cellular inhibition is associated with reduced risk against febrile malaria in a longitudinal cohort study involving Ghanaian children

    Tiendrebeogo, R. W., Adu, B., Singh, S. K., Dziegiel, M. H., Nébié, I., Sirima, S. B., Christiansen, M., Dodoo, D. & Theisen, M., 2015, In : Open forum in Infectious Diseases. 2, 2, 5 p., ofv044.

    Research output: Contribution to journalLetterResearchpeer-review

  14. Published

    A multi-stage malaria vaccine candidate targeting both transmission and asexual parasite life-cycle stages

    Theisen, M., Roeffen, W., Singh, S. K., Andersen, G., Amoah, L., van de Vegte-Bolmer, M., Arens, T., Tiendrebeogo, R. W., Jones, S., Bousema, T., Adu, B., Dziegiel, M. H., Christiansen, M. & Sauerwein, R., 2014, In : Vaccine. 32, 22, p. 2623–2630 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    High-throughput tri-colour flow cytometry technique to assess Plasmodium falciparum parasitaemia in bioassays

    Tiendrebeogo, R. W., Adu, B., Singh, S. K., Dodoo, D., Dziegiel, M. H., Mordmüller, B., Nébié, I., Sirima, S. B., Christiansen, M. & Theisen, M., 2014, In : Malaria Journal. 13, 1, p. 412

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The Malaria Vaccine Candidate GMZ2 Elicits Functional Antibodies in Individuals From Malaria Endemic and Non-Endemic Areas

    Jepsen, M. P. G., Jogdand, P. S., Singh, S. K., Esen, M., Christiansen, M., Issifou, S., Hounkpatin, A. B., Ateba-Ngoa, U., Kremsner, P. G., Dziegiel, M. H., Olesen-Larsen, S., Jepsen, S., Mordmüller, B. & Theisen, M., Aug 2013, In : The Journal of Infectious Diseases. 208, 3, p. 479-88 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Flow cytometric readout based on Mitotracker Red CMXRos staining of live asexual blood stage malarial parasites reliably assesses antibody dependent cellular inhibition

    Jogdand, P. S., Singh, S. K., Christiansen, M., Dziegiel, M. H., Singh, S. & Theisen, M., 2012, In : Malaria Journal. 11, 1, p. 235

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 33608855