Niels Høiby

Niels Høiby

Professor

  • Bacteriology

    Blegdamsvej 3B, Building: 22.2.21

    2200 København N.

    Mobile: +45 40 46 35 32Fax: +45 35 45 64 12

  1. 2020
  2. E-pub ahead of print

    Antibody response against Pseudomonas aeruginosa and its relationship with immune mediators in the upper and lower airways of cystic fibrosis patients

    Mauch, R. M., Hentschel, J., Aanæs, Kasper, Barucha, A., Nolasco da Silva, M. T., Levy, C. E., Høiby, Niels & Mainz, J. G., 2020, In : Pediatric Pulmonology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Biofilms of mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation

    Kolpen, M., Jensen, Peter Østrup, Qvist, T., Kragh, Kasper Nørskov, Ravnholt, C., Fritz, Blaine Gabriel, Johansen, U. R., Bjarnsholt, Thomas & Høiby, Niels, 2020, In : Antimicrobial Agents and Chemotherapy. 64, 2, e01212.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Further Commentary

    Hengzhuang, W. & Høiby, Niels, 2020, In : Pediatric Pulmonology. 55, 1, 1 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  5. Accepted/In press

    In vivo demonstration of Pseudomonas aeruginosa biofilms as independent pharmacological microcompartments

    Christophersen, L., Schwartz, F. A., Lerche, C. J., Svanekjær, T., Kragh, Kasper Nørskov, Laulund, A. S., Thomsen, Kim, Henneberg, K. Å., Sams, T., Høiby, Niels & Moser, Claus Ernst, 2020, (Accepted/In press) In : Journal of Cystic Fibrosis.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs

    Arndal, E., Johansen, Helle Krogh, Haagensen, J. A. J., Bartell, J. A., Marvig, R. L., Alanin, Mikkel Christian, Aanæs, Kasper, Høiby, Niels, Nielsen, Kim G., Backer, Vibeke & von Buchwald, Christian, 2020, In : The European Respiratory Journal. 55, 1, 1901472.

    Research output: Contribution to journalLetterResearchpeer-review

  7. Accepted/In press

    Pseudomonas aeruginosa antibody response in cystic fibrosis decreases rapidly following lung transplantation

    Schwensen, H. F., Moser, Claus Ernst, Perch, Michael, Pressler, T. & Høiby, Niels, 2020, (Accepted/In press) In : Journal of Cystic Fibrosis.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    The evolutionary trajectories of P. aeruginosa in biofilm and planktonic growth modes exposed to ciprofloxacin: beyond selection of antibiotic resistance

    Ahmed, M. N., Abdelsamad, A., Wassermann, T., Porse, A., Becker, J., Sommer, M. O. A., Høiby, Niels & Ciofu, Oana, 2020, In : NPJ biofilms and microbiomes. 6, 1, 10 p., 28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2019
  10. Published

    P. aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage-ciprofloxacin combination: —monitoring the phage–P. aeruginosa biofilms interactions

    Henriksen, K., Rørbo, N., Rybtke, Morten Levin, Martinet, M. G., Tolker-Nielsen, Tim, Høiby, Niels, Middelboe, Mathias & Ciofu, Oana, 2019, In : Pathogens and Disease. 77, 2, 11 p., ftz011.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Adjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis

    Lerche, C. J., Christophersen, L. J., Goetze, J. P., Nielsen, P. R., Thomsen, K., Enevold, C., Høiby, Niels, Jensen, Peter Østrup, Bundgård, Henning & Moser, Claus Ernst, 2019, In : PLoS ONE. 14, 4, 16 p., e0215333.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Antibiotic therapy as personalized medicine - general considerations and complicating factors

    Moser, Claus Ernst, Lerche, C. J., Thomsen, Kim, Hartvig, T., Schierbeck, J., Jensen, Peter Østrup, Ciofu, Oana & Høiby, Niels, 2019, In : APMIS. 127, 5, p. 361-371

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Antibody response against Mycobacterium avium complex in cystic fibrosis patients measured by a novel IgG ELISA test

    Ravnholt, C., Qvist, T., Kolpen, M., Pressler, T., Skov, M. & Høiby, Niels, 2019, In : Journal of Cystic Fibrosis. 18, 4, p. 516-521

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients

    Molchanova, N., Wang, H., Hansen, Paul Robert, Høiby, Niels, Nielsen, Hanne Mørck & Franzyk, Henrik, 2019, In : Frontiers in Microbiology. 10, 9 p., 275.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Editorial comment

    Moser, Claus Ernst, Song, Z. & Høiby, Niels, 2019, In : APMIS. 127, 5, 1 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  16. Published

    Formation of Pseudomonas aeruginosa inhibition zone during tobramycin disk diffusion is due to transition from planktonic to biofilm mode of growth

    Høiby, Niels, Henneberg, K. Å., Wang, H., Stavnsbjerg, C., Bjarnsholt, Thomas, Ciofu, Oana, Johansen, U. R. & Sams, T., 2019, In : International Journal of Antimicrobial Agents. 53, 5, p. 564-573

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Hyperbaric oxygen treatment increases killing of aggregating Pseudomonas aeruginosa isolates from cystic fibrosis patients

    Møller, S. A., Jensen, Peter Østrup, Høiby, Niels, Ciofu, Oana, Kragh, Kasper Nørskov, Bjarnsholt, Thomas & Kolpen, M., 2019, In : Journal of Cystic Fibrosis. 18, 5, p. 657–664

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air

    Jensen, Peter Østrup, Møller, S. A., Lerche, C. J., Moser, Claus Ernst, Bjarnsholt, Thomas, Ciofu, Oana, Faurholt-jepsen, D., Høiby, Niels & Kolpen, M., 2019, In : Biofilm. 1, 4 p., 100008.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Lack of the Major Multifunctional Catalase KatA in Pseudomonas aeruginosa Accelerates Evolution of Antibiotic Resistance in Ciprofloxacin-Treated Biofilms

    Ahmed, M. N., Porse, A., Abdelsamad, A., Sommer, M., Høiby, Niels & Ciofu, Oana, 2019, In : Antimicrobial Agents and Chemotherapy. 63, 10, 12 p., e00766-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Optimization of colistin dosing regimen for cystic fibrosis patients with chronic Pseudomonas aeruginosa biofilm lung infections

    Hengzhuang, W., Green, K., Pressler, T., Skov, M., Katzenstein, T. L., Wu, X. & Høiby, Niels, 2019, In : Pediatric Pulmonology. 54, 5, p. 575-580

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Secretory IgA-mediated immune response in saliva and early detection of Pseudomonas aeruginosa in the lower airways of pediatric cystic fibrosis patients

    Mauch, R. M., Rossi, C. L., Nolasco da Silva, M. T., Bianchi Aiello, T., Ribeiro, J. D., Ribeiro, A. F., Høiby, Niels & Levy, C. E., 2019, In : Medical microbiology and immunology. 208, 2, p. 205-213 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2018
  23. Published

    Evolution of Antibiotic Resistance in Biofilm and Planktonic Pseudomonas aeruginosa Populations Exposed to Subinhibitory Levels of Ciprofloxacin

    Ahmed, M. N. A., Porse, A., Sommer, M., Høiby, Niels & Ciofu, Oana, 1 Aug 2018, In : Antimicrobial Agents and Chemotherapy. 62, 8, 12 p., e00320-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Pseudomonas aeruginosa biofilm hampers murine central wound healing by suppression of vascular epithelial growth factor

    Trøstrup, H., Lerche, C. J., Christophersen, L. J., Thomsen, Kim, Jensen, Peter Østrup, Hougen, H. P., Høiby, Niels & Moser, Claus Ernst, Feb 2018, In : International Wound Journal. 15, 1, p. 123-132

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    A systematic review of studies on the faecal microbiota in anorexia nervosa: future research may need to include microbiota from the small intestine

    Schwensen, H. F., Kan, C., Treasure, J., Høiby, Niels & Sjögren, Magnus, 2018, In : Eating and Weight Disorders. 23, 4, p. 399-418

    Research output: Contribution to journalReviewResearchpeer-review

  26. Published

    Adaptation of Pseudomonas aeruginosa to the chronic phenotype by mutations in the algTmucABD operon in isolates from Brazilian cystic fibrosis patients

    Caçador, N. C., Paulino da Costa Capizzani, C., Monteiro Marin Torres, L. A. G., Galetti, R., Ciofu, Oana, Lúcia da Costa Darini, A. & Høiby, Niels, 2018, In : PLoS ONE. 13, 11, 11 p., e0208013.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published
  28. Published

    IgG avidity to Pseudomonas aeruginosa over the course of chronic lung biofilm infection in cystic fibrosis

    Mauch, R. M., Nørregaard, L. L., Ciofu, Oana, Levy, C. E. & Høiby, Niels, 2018, In : Journal of Cystic Fibrosis. 17, 3, p. 356-359

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis

    Mauch, R. M., Jensen, Peter Østrup, Moser, Claus Ernst, Levy, C. E. & Høiby, Niels, 2018, In : Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 17, 2, p. 143-152

    Research output: Contribution to journalReviewResearchpeer-review

  30. Published

    Modelling of ciprofloxacin killing enhanced by hyperbaric oxygen treatment in Pseudomonas aeruginosa PAO1 biofilms

    Gade, P. A. V., Olsen, T. B., Jensen, Peter Østrup, Kolpen, M., Høiby, Niels, Henneberg, K. Å. & Sams, T., 2018, In : PLoS ONE. 13, 6, 16 p., e0198909.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Next generation microbiology and cystic fibrosis diagnostics: are we there yet?

    Moser, Claus Ernst, Thomsen, T. R. & Høiby, Niels, 2018, In : Current Opinion in Pulmonary Medicine. 24, 6, p. 599-605

    Research output: Contribution to journalReviewResearchpeer-review

  32. Published

    The importance of early diagnosis of Mycobacterium abscessus complex in patients with cystic fibrosis

    Ravnholt, C., Kolpen, M., Skov, M., Moser, C., Katzenstein, T. L., Pressler, T., Høiby, Niels & Qvist, T., 2018, In : APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 126, 12, p. 885-891 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. 2017
  34. Published

    Hyperbaric oxygen sensitizes anoxic Pseudomonas aeruginosa biofilm to ciprofloxacin

    Kolpen, M., Lerche, C. J., Kragh, Kasper Nørskov, Sams, T., Koren, K., Jensen, A. S., Line, L., Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus Ernst, Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, Nov 2017, In : Antimicrobial Agents and Chemotherapy. 61, 11, 9 p., e01024-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Chronic Pseudomonas aeruginosa biofilm infection impairs murine S100A8/A9 and neutrophil effector cytokines—implications for delayed wound closure?

    Trøstrup, H., Lerche, C. J., Christophersen, L. J., Thomsen, Kim, Jensen, Peter Østrup, Hougen, H. P., Høiby, Niels & Moser, Claus Ernst, Oct 2017, In : Pathogens and Disease. 75, 7, 10 p., ftx068.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    O-2 AFFECTS THE ACTIVITY OF AMIKACIN ON MYCOBACTERIUM ABSCESSUS BIOFILM

    Kolpen, M., Ravnholt, C., Qvist, T., Kragh, Kasper Nørskov, Fritz, Blaine Gabriel, Bjarnsholt, Thomas, Høiby, Niels & Jensen, Peter Østrup, Sep 2017, In : Pediatric Pulmonology. 52, S47, p. S359-S360 379.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  37. Published

    Experimental Pseudomonas aeruginosa mediated rhino sinusitis in mink

    Kirkeby, S., Hammer, Anne Sofie Vedsted, Høiby, Niels & Salomonsen, C. M., May 2017, In : International Journal of Pediatric Otorhinolaryngology. 96, p. 156-163 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    A short history of microbial biofilms and biofilm infections

    Høiby, Niels, Apr 2017, In : APMIS. 125, 4, p. 272-275 4 p.

    Research output: Contribution to journalReviewResearchpeer-review

  39. Published

    Biofilms and host response - helpful or harmful

    Moser, Claus Ernst, Pedersen, H. T., Lerche, C. J., Kolpen, M., Line, L., Thomsen, Kim, Høiby, Niels & Jensen, Peter Østrup, Apr 2017, In : A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 125, 4, p. 320-338 19 p.

    Research output: Contribution to journalReviewResearchpeer-review

  40. Published

    Chronic urinary tract infections in patients with spinal cord lesions – biofilm infection with need for long-term antibiotic treatment

    Tofte, N., Nielsen, A. C. Y., Trøstrup, H., Andersen, C. B., Von Linstow, M., Hansen, B., Biering-Sørensen, Fin, Høiby, Niels & Moser, Claus Ernst, Apr 2017, In : APMIS. 125, 4, p. 385-391 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  41. Published

    Diagnosis of biofilm infections in cystic fibrosis patients

    Høiby, Niels, Bjarnsholt, Thomas, Moser, Claus Ernst, Jensen, Peter Østrup, Kolpen, M., Qvist, T., Aanæs, Kasper, Pressler, T., Skov, M. & Ciofu, Oana, Apr 2017, In : A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 125, 4, p. 339-343 5 p.

    Research output: Contribution to journalReviewResearchpeer-review

  42. Published

    Individual pharmacokinetic variation leads to underdosing of ciprofloxacin in some cystic fibrosis patients

    Schultz, A. N. Ø., Høiby, Niels, Nielsen, X. C., Pressler, T., Dalhoff, Kim, Duno, M., Buchard, Anders, Johansen, H. K., Wang, H. & Dalbøge, C. S., Mar 2017, In : Pediatric Pulmonology. 52, 3, p. 319-323 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Phenotypic shift in Pseudomonas aeruginosa populations from cystic fibrosis lungs after 2-week antipseudomonal treatment

    Fernandez-Barat, L., Ciofu, Oana, Kragh, Kasper Nørskov, Pressler, T., Johansen, U., Motos, A., Torres, A. & Høiby, Niels, Mar 2017, In : Journal of Cystic Fibrosis. 16, 2, p. 222-229

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Sinus surgery can improve quality of life, lung infections, and lung function in patients with primary ciliary dyskinesia

    Alanin, M. C., Aanæs, Kasper, Høiby, Niels, Pressler, T., Skov, M., Nielsen, Kim G., Johansen, Helle Krogh & von Buchwald, Christian, Mar 2017, In : International Forum of Allergy Rhinology. 7, 3, p. 240-247

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Evaluation of a bovine antibody test for diagnosing Mycobacterium avium complex in patients with cystic fibrosis

    Qvist, T., Pressler, T., Katzenstein, T. L., Høiby, Niels & Collins, M. T., Jan 2017, In : Pediatric Pulmonology. 52, 1, p. 34-40 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Hyperbaric oxygen treatment augments tobramycin efficacy in experimental staphylococcus aureus endocarditis

    Lerche, C. J., Christophersen, L. J., Kolpen, M., Nielsen, P. R., Trøstrup, H., Thomsen, Kim, Hyldegaard, O., Bundgård, Henning, Jensen, Peter Østrup, Høiby, Niels & Moser, Claus Ernst, 2017, In : International Journal of Antimicrobial Agents. 50, 3, p. 406-412

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Immune Modulating Topical S100A8/A9 Inhibits Growth of Pseudomonas aeruginosa and Mitigates Biofilm Infection in Chronic Wounds

    Trøstrup, H., Lerche, C. J., Christophersen, L., Jensen, Peter Østrup, Høiby, Niels & Moser, Claus Ernst, 2017, In : International Journal of Molecular Sciences. 18, 7, 13 p., 1359.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Secretory IgA response against Pseudomonas aeruginosa in the upper airways and the link with chronic lung infection in cystic fibrosis

    Mauch, R. M., Rossi, C. L., Aiello, T. B., Ribeiro, J. D., Ribeiro, A. F., Høiby, Niels & Levy, C. E., 2017, In : Pathogens and Disease. 75, 6, 4 p., ftx069.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Sinus bacteriology in patients with cystic fibrosis or primary ciliary dyskinesia: A systematic review

    Møller, M. E., Alanin, M. C., Grønhøj, C., Aanæs, Kasper, Høiby, Niels & von Buchwald, Christian, 2017, In : American Journal of Rhinology and Allergy. 31, 5, p. 293-298 6 p.

    Research output: Contribution to journalReviewResearchpeer-review

  50. 2016
  51. Published

    The dlt genes play a role in antimicrobial tolerance of Streptococcus mutans biofilms

    Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Givskov, Michael, Høiby, Niels, Twetman, Svante & Tolker-Nielsen, Tim, Sep 2016, In : International Journal of Antimicrobial Agents. 48, 3, p. 298–304

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    S100A8/A9 is an important host defence mediator in neuropathic foot ulcers in patients with type 2 diabetes mellitus

    Trøstrup, H., Holstein, P., Christophersen, L., Jørgensen, B., Karlsmark, Tonny, Høiby, Niels, Moser, Claus Ernst & Ågren, Magnus, 1 Jul 2016, In : Archives of Dermatological Research. 308, 5, p. 347-355 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils

    Thomsen, K., Christophersen, L., Jensen, Peter Østrup, Bjarnsholt, Thomas, Moser, Claus Ernst & Høiby, Niels, Jul 2016, In : Human Vaccines & Immunotherapeutics. 12, 7, p. 1690-1699 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Activation of pulmonary and lymph node dendritic cells during chronic Pseudomonas aeruginosa lung infection in mice

    Damlund, D. S. M., Christophersen, L., Jensen, Peter Østrup, Alhede, M., Høiby, Niels & Moser, Claus Ernst, Jun 2016, In : APMIS - Journal of Pathology, Microbiology and Immunology. 124, 6, p. 500-507 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    The phenotypic evolution of pseudomonas aeruginosa populations changes in the presence of subinhibitory concentrations of ciprofloxacin

    Wassermann, T., Jørgensen, K. M., Ivanyshyn, K., Bjarnsholt, Thomas, Hossein Khademi, S. M., Jelsbak, L., Høiby, Niels & Ciofu, Oana, 1 May 2016, In : Microbiology. 162, 5, p. 865-875 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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