Niels Høiby

Niels Høiby

Professor

  • Bacteriology

    Blegdamsvej 3B, Building: 22.2.21

    2200 København N.

    Mobile: +45 40 46 35 32Fax: +45 35 45 64 12

  1. 2020
  2. E-pub ahead of print

    Antibody response against Pseudomonas aeruginosa and its relationship with immune mediators in the upper and lower airways of cystic fibrosis patients

    Mauch, R. M., Hentschel, J., Aanæs, Kasper, Barucha, A., Nolasco da Silva, M. T., Levy, C. E., Høiby, Niels & Mainz, J. G., 2020, In : Pediatric Pulmonology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Biofilms of mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation

    Kolpen, M., Jensen, Peter Østrup, Qvist, T., Kragh, Kasper Nørskov, Ravnholt, C., Fritz, Blaine Gabriel, Johansen, U. R., Bjarnsholt, Thomas & Høiby, Niels, 2020, In : Antimicrobial Agents and Chemotherapy. 64, 2, e01212.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Further Commentary

    Hengzhuang, W. & Høiby, Niels, 2020, In : Pediatric Pulmonology. 55, 1, 1 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  5. Accepted/In press

    In vivo demonstration of Pseudomonas aeruginosa biofilms as independent pharmacological microcompartments

    Christophersen, L., Schwartz, F. A., Lerche, C. J., Svanekjær, T., Kragh, Kasper Nørskov, Laulund, A. S., Thomsen, Kim, Henneberg, K. Å., Sams, T., Høiby, Niels & Moser, Claus Ernst, 2020, (Accepted/In press) In : Journal of Cystic Fibrosis.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs

    Arndal, E., Johansen, Helle Krogh, Haagensen, J. A. J., Bartell, J. A., Marvig, R. L., Alanin, Mikkel Christian, Aanæs, Kasper, Høiby, Niels, Nielsen, Kim G., Backer, Vibeke & von Buchwald, Christian, 2020, In : The European Respiratory Journal. 55, 1, 1901472.

    Research output: Contribution to journalLetterResearchpeer-review

  7. Accepted/In press

    Pseudomonas aeruginosa antibody response in cystic fibrosis decreases rapidly following lung transplantation

    Schwensen, H. F., Moser, Claus Ernst, Perch, Michael, Pressler, T. & Høiby, Niels, 2020, (Accepted/In press) In : Journal of Cystic Fibrosis.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2019
  9. Published

    P. aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage-ciprofloxacin combination: —monitoring the phage–P. aeruginosa biofilms interactions

    Henriksen, K., Rørbo, N., Rybtke, Morten Levin, Martinet, M. G., Tolker-Nielsen, Tim, Høiby, Niels, Middelboe, Mathias & Ciofu, Oana, 2019, In : Pathogens and Disease. 77, 2, 11 p., ftz011.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Adjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis

    Lerche, C. J., Christophersen, L. J., Goetze, J. P., Nielsen, P. R., Thomsen, K., Enevold, C., Høiby, Niels, Jensen, Peter Østrup, Bundgård, Henning & Moser, Claus Ernst, 2019, In : PLoS ONE. 14, 4, 16 p., e0215333.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Antibiotic therapy as personalized medicine - general considerations and complicating factors

    Moser, Claus Ernst, Lerche, C. J., Thomsen, Kim, Hartvig, T., Schierbeck, J., Jensen, Peter Østrup, Ciofu, Oana & Høiby, Niels, 2019, In : APMIS. 127, 5, p. 361-371

    Research output: Contribution to journalReviewResearchpeer-review

  12. Published

    Antibody response against Mycobacterium avium complex in cystic fibrosis patients measured by a novel IgG ELISA test

    Ravnholt, C., Qvist, T., Kolpen, M., Pressler, T., Skov, M. & Høiby, Niels, 2019, In : Journal of Cystic Fibrosis. 18, 4, p. 516-521

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients

    Molchanova, N., Wang, H., Hansen, Paul Robert, Høiby, Niels, Nielsen, Hanne Mørck & Franzyk, Henrik, 2019, In : Frontiers in Microbiology. 10, 9 p., 275.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Editorial comment

    Moser, Claus Ernst, Song, Z. & Høiby, Niels, 2019, In : APMIS. 127, 5, 1 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  15. Published

    Formation of Pseudomonas aeruginosa inhibition zone during tobramycin disk diffusion is due to transition from planktonic to biofilm mode of growth

    Høiby, Niels, Henneberg, K. Å., Wang, H., Stavnsbjerg, C., Bjarnsholt, Thomas, Ciofu, Oana, Johansen, U. R. & Sams, T., 2019, In : International Journal of Antimicrobial Agents. 53, 5, p. 564-573

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Hyperbaric oxygen treatment increases killing of aggregating Pseudomonas aeruginosa isolates from cystic fibrosis patients

    Møller, S. A., Jensen, Peter Østrup, Høiby, Niels, Ciofu, Oana, Kragh, Kasper Nørskov, Bjarnsholt, Thomas & Kolpen, M., 2019, In : Journal of Cystic Fibrosis. 18, 5, p. 657–664

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air

    Jensen, Peter Østrup, Møller, S. A., Lerche, C. J., Moser, Claus Ernst, Bjarnsholt, Thomas, Ciofu, Oana, Faurholt-jepsen, D., Høiby, Niels & Kolpen, M., 2019, In : Biofilm. 1, 4 p., 100008.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Lack of the Major Multifunctional Catalase KatA in Pseudomonas aeruginosa Accelerates Evolution of Antibiotic Resistance in Ciprofloxacin-Treated Biofilms

    Ahmed, M. N., Porse, A., Abdelsamad, A., Sommer, M., Høiby, Niels & Ciofu, Oana, 2019, In : Antimicrobial Agents and Chemotherapy. 63, 10, 12 p., e00766-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Optimization of colistin dosing regimen for cystic fibrosis patients with chronic Pseudomonas aeruginosa biofilm lung infections

    Hengzhuang, W., Green, K., Pressler, T., Skov, M., Katzenstein, T. L., Wu, X. & Høiby, Niels, 2019, In : Pediatric Pulmonology. 54, 5, p. 575-580

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Secretory IgA-mediated immune response in saliva and early detection of Pseudomonas aeruginosa in the lower airways of pediatric cystic fibrosis patients

    Mauch, R. M., Rossi, C. L., Nolasco da Silva, M. T., Bianchi Aiello, T., Ribeiro, J. D., Ribeiro, A. F., Høiby, Niels & Levy, C. E., 2019, In : Medical microbiology and immunology. 208, 2, p. 205-213 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. 2018
  22. Published

    Evolution of Antibiotic Resistance in Biofilm and Planktonic Pseudomonas aeruginosa Populations Exposed to Subinhibitory Levels of Ciprofloxacin

    Ahmed, M. N. A., Porse, A., Sommer, M., Høiby, Niels & Ciofu, Oana, 1 Aug 2018, In : Antimicrobial Agents and Chemotherapy. 62, 8, 12 p., e00320-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Pseudomonas aeruginosa biofilm hampers murine central wound healing by suppression of vascular epithelial growth factor

    Trøstrup, H., Lerche, C. J., Christophersen, L. J., Thomsen, Kim, Jensen, Peter Østrup, Hougen, H. P., Høiby, Niels & Moser, Claus Ernst, Feb 2018, In : International Wound Journal. 15, 1, p. 123-132

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    A systematic review of studies on the faecal microbiota in anorexia nervosa: future research may need to include microbiota from the small intestine

    Schwensen, H. F., Kan, C., Treasure, J., Høiby, Niels & Sjögren, Magnus, 2018, In : Eating and Weight Disorders. 23, 4, p. 399-418

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Adaptation of Pseudomonas aeruginosa to the chronic phenotype by mutations in the algTmucABD operon in isolates from Brazilian cystic fibrosis patients

    Caçador, N. C., Paulino da Costa Capizzani, C., Monteiro Marin Torres, L. A. G., Galetti, R., Ciofu, Oana, Lúcia da Costa Darini, A. & Høiby, Niels, 2018, In : PLoS ONE. 13, 11, 11 p., e0208013.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published
  27. Published

    IgG avidity to Pseudomonas aeruginosa over the course of chronic lung biofilm infection in cystic fibrosis

    Mauch, R. M., Nørregaard, L. L., Ciofu, Oana, Levy, C. E. & Høiby, Niels, 2018, In : Journal of Cystic Fibrosis. 17, 3, p. 356-359

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis

    Mauch, R. M., Jensen, Peter Østrup, Moser, Claus Ernst, Levy, C. E. & Høiby, Niels, 2018, In : Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 17, 2, p. 143-152

    Research output: Contribution to journalReviewResearchpeer-review

  29. Published

    Modelling of ciprofloxacin killing enhanced by hyperbaric oxygen treatment in Pseudomonas aeruginosa PAO1 biofilms

    Gade, P. A. V., Olsen, T. B., Jensen, Peter Østrup, Kolpen, M., Høiby, Niels, Henneberg, K. Å. & Sams, T., 2018, In : PLoS ONE. 13, 6, 16 p., e0198909.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Next generation microbiology and cystic fibrosis diagnostics: are we there yet?

    Moser, Claus Ernst, Thomsen, T. R. & Høiby, Niels, 2018, In : Current Opinion in Pulmonary Medicine. 24, 6, p. 599-605

    Research output: Contribution to journalReviewResearchpeer-review

  31. Published

    The importance of early diagnosis of Mycobacterium abscessus complex in patients with cystic fibrosis

    Ravnholt, C., Kolpen, M., Skov, M., Moser, C., Katzenstein, T. L., Pressler, T., Høiby, Niels & Qvist, T., 2018, In : APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 126, 12, p. 885-891 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. 2017
  33. Published

    Hyperbaric oxygen sensitizes anoxic Pseudomonas aeruginosa biofilm to ciprofloxacin

    Kolpen, M., Lerche, C. J., Kragh, Kasper Nørskov, Sams, T., Koren, K., Jensen, A. S., Line, L., Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus Ernst, Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, Nov 2017, In : Antimicrobial Agents and Chemotherapy. 61, 11, 9 p., e01024-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Chronic Pseudomonas aeruginosa biofilm infection impairs murine S100A8/A9 and neutrophil effector cytokines—implications for delayed wound closure?

    Trøstrup, H., Lerche, C. J., Christophersen, L. J., Thomsen, Kim, Jensen, Peter Østrup, Hougen, H. P., Høiby, Niels & Moser, Claus Ernst, Oct 2017, In : Pathogens and Disease. 75, 7, 10 p., ftx068.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    O-2 AFFECTS THE ACTIVITY OF AMIKACIN ON MYCOBACTERIUM ABSCESSUS BIOFILM

    Kolpen, M., Ravnholt, C., Qvist, T., Kragh, Kasper Nørskov, Fritz, Blaine Gabriel, Bjarnsholt, Thomas, Høiby, Niels & Jensen, Peter Østrup, Sep 2017, In : Pediatric Pulmonology. 52, S47, p. S359-S360 379.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  36. Published

    Experimental Pseudomonas aeruginosa mediated rhino sinusitis in mink

    Kirkeby, Svend, Hammer, Anne Sofie Vedsted, Høiby, Niels & Salomonsen, C. M., May 2017, In : International Journal of Pediatric Otorhinolaryngology. 96, p. 156-163 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    A short history of microbial biofilms and biofilm infections

    Høiby, Niels, Apr 2017, In : APMIS. 125, 4, p. 272-275 4 p.

    Research output: Contribution to journalReviewResearchpeer-review

  38. Published

    Biofilms and host response - helpful or harmful

    Moser, Claus Ernst, Pedersen, H. T., Lerche, C. J., Kolpen, M., Line, L., Thomsen, Kim, Høiby, Niels & Jensen, Peter Østrup, Apr 2017, In : A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 125, 4, p. 320-338 19 p.

    Research output: Contribution to journalReviewResearchpeer-review

  39. Published

    Chronic urinary tract infections in patients with spinal cord lesions – biofilm infection with need for long-term antibiotic treatment

    Tofte, N., Nielsen, A. C. Y., Trøstrup, H., Andersen, C. B., Von Linstow, M., Hansen, B., Biering-Sørensen, Fin, Høiby, Niels & Moser, Claus Ernst, Apr 2017, In : APMIS. 125, 4, p. 385-391 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  40. Published

    Diagnosis of biofilm infections in cystic fibrosis patients

    Høiby, Niels, Bjarnsholt, Thomas, Moser, Claus Ernst, Jensen, Peter Østrup, Kolpen, M., Qvist, T., Aanæs, Kasper, Pressler, T., Skov, M. & Ciofu, Oana, Apr 2017, In : A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 125, 4, p. 339-343 5 p.

    Research output: Contribution to journalReviewResearchpeer-review

  41. Published

    Individual pharmacokinetic variation leads to underdosing of ciprofloxacin in some cystic fibrosis patients

    Schultz, A. N. Ø., Høiby, Niels, Nielsen, X. C., Pressler, T., Dalhoff, Kim, Duno, M., Buchard, Anders, Johansen, H. K., Wang, H. & Dalbøge, C. S., Mar 2017, In : Pediatric Pulmonology. 52, 3, p. 319-323 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Phenotypic shift in Pseudomonas aeruginosa populations from cystic fibrosis lungs after 2-week antipseudomonal treatment

    Fernandez-Barat, L., Ciofu, Oana, Kragh, Kasper Nørskov, Pressler, T., Johansen, U., Motos, A., Torres, A. & Høiby, Niels, Mar 2017, In : Journal of Cystic Fibrosis. 16, 2, p. 222-229

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Sinus surgery can improve quality of life, lung infections, and lung function in patients with primary ciliary dyskinesia

    Alanin, M. C., Aanæs, Kasper, Høiby, Niels, Pressler, T., Skov, M., Nielsen, Kim G., Johansen, Helle Krogh & von Buchwald, Christian, Mar 2017, In : International Forum of Allergy Rhinology. 7, 3, p. 240-247

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Evaluation of a bovine antibody test for diagnosing Mycobacterium avium complex in patients with cystic fibrosis

    Qvist, T., Pressler, T., Katzenstein, T. L., Høiby, Niels & Collins, M. T., Jan 2017, In : Pediatric Pulmonology. 52, 1, p. 34-40 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Hyperbaric oxygen treatment augments tobramycin efficacy in experimental staphylococcus aureus endocarditis

    Lerche, C. J., Christophersen, L. J., Kolpen, M., Nielsen, P. R., Trøstrup, H., Thomsen, Kim, Hyldegaard, O., Bundgård, Henning, Jensen, Peter Østrup, Høiby, Niels & Moser, Claus Ernst, 2017, In : International Journal of Antimicrobial Agents. 50, 3, p. 406-412

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Immune Modulating Topical S100A8/A9 Inhibits Growth of Pseudomonas aeruginosa and Mitigates Biofilm Infection in Chronic Wounds

    Trøstrup, H., Lerche, C. J., Christophersen, L., Jensen, Peter Østrup, Høiby, Niels & Moser, Claus Ernst, 2017, In : International Journal of Molecular Sciences. 18, 7, 13 p., 1359.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Secretory IgA response against Pseudomonas aeruginosa in the upper airways and the link with chronic lung infection in cystic fibrosis

    Mauch, R. M., Rossi, C. L., Aiello, T. B., Ribeiro, J. D., Ribeiro, A. F., Høiby, Niels & Levy, C. E., 2017, In : Pathogens and Disease. 75, 6, 4 p., ftx069.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Sinus bacteriology in patients with cystic fibrosis or primary ciliary dyskinesia: A systematic review

    Møller, M. E., Alanin, M. C., Grønhøj, C., Aanæs, Kasper, Høiby, Niels & von Buchwald, Christian, 2017, In : American Journal of Rhinology and Allergy. 31, 5, p. 293-298 6 p.

    Research output: Contribution to journalReviewResearchpeer-review

  49. 2016
  50. Published

    The dlt genes play a role in antimicrobial tolerance of Streptococcus mutans biofilms

    Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Givskov, Michael, Høiby, Niels, Twetman, Svante & Tolker-Nielsen, Tim, Sep 2016, In : International Journal of Antimicrobial Agents. 48, 3, p. 298–304

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    S100A8/A9 is an important host defence mediator in neuropathic foot ulcers in patients with type 2 diabetes mellitus

    Trøstrup, H., Holstein, P., Christophersen, L., Jørgensen, B., Karlsmark, Tonny, Høiby, Niels, Moser, Claus Ernst & Ågren, Magnus, 1 Jul 2016, In : Archives of Dermatological Research. 308, 5, p. 347-355 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils

    Thomsen, K., Christophersen, L., Jensen, Peter Østrup, Bjarnsholt, Thomas, Moser, Claus Ernst & Høiby, Niels, Jul 2016, In : Human Vaccines & Immunotherapeutics. 12, 7, p. 1690-1699 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Activation of pulmonary and lymph node dendritic cells during chronic Pseudomonas aeruginosa lung infection in mice

    Damlund, D. S. M., Christophersen, L., Jensen, Peter Østrup, Alhede, M., Høiby, Niels & Moser, Claus Ernst, Jun 2016, In : APMIS - Journal of Pathology, Microbiology and Immunology. 124, 6, p. 500-507 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    The phenotypic evolution of pseudomonas aeruginosa populations changes in the presence of subinhibitory concentrations of ciprofloxacin

    Wassermann, T., Jørgensen, K. M., Ivanyshyn, K., Bjarnsholt, Thomas, Hossein Khademi, S. M., Jelsbak, L., Høiby, Niels & Ciofu, Oana, 1 May 2016, In : Microbiology. 162, 5, p. 865-875 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Diffusion retardation by binding of tobramycin in an alginate biofilm model

    Cao, B., Christophersen, L., Kolpen, M., Jensen, Peter Østrup, Sneppen, Kim, Høiby, Niels, Moser, Claus Ernst & Sams, T., 21 Apr 2016, In : P L o S One. 11, 4, 11 p., e0153616.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    New technology markedly improves hand-hygiene performance among healthcare workers after restroom visits

    Møller-Sørensen, H., Korshin, A., Mogensen, T. & Høiby, Niels, Apr 2016, In : Journal of Hospital Infection. 92, 4, p. 337-339 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

  57. Published

    Anti-Pseudomonas aeruginosa IgY antibodies augment bacterial clearance in a murine pneumonia model

    Thomsen, K., Christophersen, L., Bjarnsholt, Thomas, Jensen, Peter Østrup, Moser, Claus Ernst & Høiby, Niels, Mar 2016, In : Journal of Cystic Fibrosis. 15, 2, p. 171-178 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Increased bactericidal activity of colistin on Pseudomonas aeruginosa biofilms in anaerobic conditions

    Kolpen, M., Appeldorff, C. F., Brandt, S., Mousavi, N., Kragh, Kasper Nørskov, Aydogan, S., Uppal, H. A., Bjarnsholt, Thomas, Ciofu, Oana, Høiby, Niels & Jensen, Peter Østrup, Feb 2016, In : Pathogens and Disease. 74, 1, 7 p., ftv086.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Animal models of chronic wound care: the application of biofilms in clinical research

    Trøstrup, H., Thomsen, K., Calum, Henrik Pierre, Høiby, Niels & Moser, Claus Ernst, 2016, In : Chronic Wound Care Management and Research. 3, p. 123-132 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  60. Published

    Bacterial evolution in PCD and CF patients follows the same mutational steps

    Sommer, L. M., Alanin, M. C., Marvig, R. L., Nielsen, Kim G., Høiby, Niels, von Buchwald, Christian, Molin, S. & Johansen, Helle Krogh, 2016, In : Scientific Reports. 6, 8 p., 28732.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Forøget renal udskillelse af antibiotika kan resultere i underdosering ved sepsis

    Moser, Claus Ernst, Hartvig, T., Schierbeck, J. & Høiby, Niels, 2016, In : Ugeskrift for Laeger. 178, p. 2-6 5 p., V05150426.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Genome sequence of Pseudomonas aeruginosa strain DK1-NH57388A, a stable mucoid cystic fibrosis isolate

    Norman, A., Ciofu, Oana, Amador, C. I., Høiby, Niels & Jelsbak, L., 2016, In : Genome Announcements. 4, 1, e00008-16.

    Research output: Contribution to journalJournal articleResearch

  63. Published

    Kai Adolf Jensen, professor i almindelig patologi

    Høiby, Niels, 2016, In : Bibliotek for Laeger. 208, 4, p. 344-361

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    OligoG CF-5/20 disruption of mucoid Pseudomonas aeruginosa biofilm in a murine lung infection model

    Wang, H., Song, Z., Ciofu, Oana, Onsøyen, E., Rye, P. D. & Høiby, Niels, 2016, In : Antimicrobial Agents and Chemotherapy. 60, 5, p. 2620-2626 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Reinforcement of the bactericidal effect of ciprofloxacin on Pseudomonas aeruginosa biofilm by hyperbaric oxygen treatment

    Kolpen, M., Mousavi, N., Sams, T., Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus Ernst, Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, 2016, In : International Journal of Antimicrobial Agents. 47, 2, p. 163–167 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  66. Published

    Sinus surgery postpones chronic gram-negative lung infection: Cohort study of 106 patients with cystic fibrosis

    Alanin, M. C., Aanæs, Kasper, Høiby, Niels, Pressler, T., Skov, M., Nielsen, K. G., Taylor-Robinson, D., Waldmann, E., Johansen, Helle Krogh & von Buchwald, Christian, 2016, In : Rhinology. 54, 3, p. 206-213 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    The phagocytic fitness of leucopatches may impact the healing of chronic wounds

    Thomsen, K., Trøstrup, H., Christophersen, L., Lundquist, R., Høiby, Niels & Moser, Claus Ernst, 2016, In : Clinical and Experimental Immunology. 184, 3, p. 368-77 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. 2015
  69. Published

    Low efficacy of tobramycin in experimental Staphylococcus aureus endocarditis

    Lerche, C. J., Christophersen, L. J., Trøstrup, H., Thomsen, K., Jensen, Peter Østrup, Hougen, H. P., Bundgaard, H., Høiby, Niels & Moser, C., 1 Dec 2015, In : European Journal of Clinical Microbiology & Infectious Diseases. 34, 12, p. 2349-2357 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. Published

    A longitudinal study of lung bacterial pathogens in patients with primary ciliary dyskinesia

    Alanin, M. C., Nielsen, K. G., von Buchwald, Christian, Skov, M., Aanæs, Kasper, Høiby, Niels & Johansen, Helle Krogh, Dec 2015, In : Clinical Microbiology and Infection. 21, 12, p. 1093.e1–1093.e7 7 p., 1093.e.

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Chronic pulmonary disease with Mycobacterium abscessus complex is a biofilm infection

    Qvist, T., Eickhardt-Dalbøge, S. R., Kragh, Kasper Nørskov, Andersen, C. B., Iversen, M., Høiby, Niels & Bjarnsholt, Thomas, Dec 2015, In : European Respiratory Journal. 46, 6, p. 1823-1826 4 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  72. Published

    The LapG protein plays a role in Pseudomonas aeruginosa biofilm formation by controlling the presence of the CdrA adhesin on the cell surface

    Rybtke, Morten Levin, Berthelsen, J., Yang, L., Høiby, Niels, Givskov, Michael & Tolker-Nielsen, Tim, Dec 2015, In : MicrobiologyOpen. 4, 6, p. 917-930 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    RE-SENSITIZATION OF ANOXIC PSEUDOMONAS AERUGINOSA BIOFILMS WITH RE-OXYGENATION USING HYPERBARIC OXYGEN TREATMENT

    Kolpen, M., Mousavi, N., Sams, T., Kragh, Kasper Nørskov, Bjarnsholt, Thomas, Ciofu, Oana, Høiby, Niels & Jensen, P. O., Oct 2015, In : Pediatric Pulmonology. 50, S41, p. 312-312 1 p., 322.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  74. Published

    Anti-Pseudomonas aeruginosa IgY Antibodies Induce Specific Bacterial Aggregation and Internalization in Human Polymorphonuclear Neutrophils

    Thomsen, K., Christophersen, L., Bjarnsholt, Thomas, Jensen, Peter Østrup, Moser, Claus Ernst & Høiby, Niels, Jul 2015, In : Infection and Immunity. 83, 7, p. 2686-2693 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    Diversity of metabolic profiles of cystic fibrosis Pseudomonas aeruginosa during the early stages of lung infection

    Jorgensen, K. M., Wassermann, T., Johansen, Helle Krogh, Christiansen, L. E., Molin, S., Høiby, Niels & Ciofu, Oana, Jul 2015, In : Microbiology. 161, 7, p. 1447-1462 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Antibiofilm Properties of Acetic Acid

    Bjarnsholt, Thomas, Alhede, M., Jensen, Peter Østrup, Nielsen, Anne Kirstine, Johansen, Helle Krogh, Homøe, Preben, Høiby, Niels, Givskov, Michael & Kirketerp-Moller, K., Jun 2015, In : Advances in Wound Care. 4, 7, p. 363-372 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa infection: a pilot study

    Skov, M., Pressler, T., Lykkesfeldt, Jens, Poulsen, Henrik Enghusen, Jensen, Peter Østrup, Johansen, Helle Krogh, Qvist, T., Kræmer, D., Høiby, Niels & Ciofu, Oana, Mar 2015, In : Journal of Cystic Fibrosis. 14, 2, p. 211-218 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    ESCMID guideline for the diagnosis and treatment of biofilm infections 2014

    Høiby, Niels, Bjarnsholt, Thomas, Moser, C., Bassi, G. L., Coenye, T., Donelli, G., Hall-Stoodley, L., Holá, V., Imbert, C., Kirketerp-Møller, K., Lebeaux, D., Oliver, A., Ullmann, A. J., Williams, C. & ESCMID Study Group for Biofilms (ESGB) and Consulting External Expert Werner Zimmerli, E. S. G. F. B. (. A. C. E. E. W. Z., 14 Jan 2015, In : Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 21, Suppl. 1, p. s1-s25 25 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Simultaneous sinus and lung infections in patients with primary ciliary dyskinesia

    Alanin, M. C., Johansen, Helle Krogh, Aanaes, K., Høiby, Niels, Pressler, T., Skov, M., Nielsen, K. G. & von Buchwald, Christian, Jan 2015, In : Acta Oto-Laryngologica. 135, 1, p. 58-63 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. Published

    Antibiotic penetration and bacterial killing in a Pseudomonas aeruginosa biofilm model

    Cao, B., Christophersen, L., Thomsen, K., Sønderholm, M., Bjarnsholt, Thomas, Jensen, Peter Østrup, Høiby, Niels & Moser, Claus Ernst, 2015, In : The Journal of antimicrobial chemotherapy. 70, 7, p. 2057-2063 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. Published

    Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients

    Ciofu, Oana, Tolker-Nielsen, Tim, Jensen, Peter Østrup, Wang, H. & Høiby, Niels, 2015, In : Advanced Drug Delivery Reviews. 85, p. 7-23 17 p.

    Research output: Contribution to journalReviewResearchpeer-review

  82. Published

    Autofluorescence in samples obtained from chronic biofilm infections – “all that glitters is not gold”

    Eickhardt-Dalbøge, S. R., Kragh, Kasper Nørskov, Schrøder, S., Poulsen, Steen Seier, Sillesen, Henrik, Givskov, Michael, Høiby, Niels, Bjarnsholt, Thomas & Alhede, M., 2015, In : Pathogens and Disease. 73, 4, 4 p., ftv012.

    Research output: Contribution to journalLetterResearchpeer-review

  83. Published

    Denitrification by cystic fibrosis pathogens - Stenotrophomonas maltophilia is dormant in sputum

    Kolpen, M., Kragh, Kasper Nørskov, Bjarnsholt, Thomas, Line, L., Hansen, C. R., Dalbøge, C. S., Hansen, N., Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, 2015, In : International Journal of Medical Microbiology. 305, 1, p. 1-10 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    PSEUDOMONAS AERUGINOSA BIOFILM INFECTION SUPPRESSES LOCAL HOST RESPONSE IN BURN WOUNDS

    Trostrup, H., Lerche, C. J., Christophersen, L., Thomsen, K., Jensen, P. O., Høiby, Niels & Moser, Claus Ernst, 2015, In : Wound Repair and Regeneration. 23, 4, p. A31-A31 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  85. Published

    S100A8/A9 WOUND FLUID LEVELS ARE REDUCED IN NON-HEALING VENOUS LEG ULCERS COMPARED WITH NEUROPATHIC FOOT ULCERS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

    Trostrup, H., Laursen, A. C., Holstein, P., Christophersen, L., Jorgensen, B., Karlsmark, Tonny, Høiby, Niels, Moser, Claus Ernst & Agren, M. S., 2015, In : Wound Repair and Regeneration. 23, 4, p. A31-A31 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  86. Published

    Strategies for combating bacterial biofilm infections

    Wu, H., Moser, Claus Ernst, Wang, H., Høiby, Niels & Song, Z., 2015, In : International Journal of Oral Science. 7, 1, p. 1-7 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  87. 2014
  88. Published

    Urine lipoarabinomannan point-of-care testing in patients affected by pulmonary nontuberculous mycobacteria - experiences from the Danish Cystic Fibrosis cohort study

    Qvist, T., Johansen, I. S., Pressler, T., Høiby, Niels, Andersen, A. B., Katzenstein, T. L. & Bjerrum, S., 4 Dec 2014, In : BMC Infectious Diseases. 14, p. 1-8 8 p., 655.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    A mariner transposon vector adapted for mutagenesis in oral streptococci

    Nilsson, M., Christiansen, N., Høiby, Niels, Twetman, Svante, Givskov, Michael & Tolker-Nielsen, Tim, Jun 2014, In : MicrobiologyOpen. 3, 3, p. 333-40 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    A personal history of research on microbial biofilms and biofilm infections

    Høiby, Niels, Apr 2014, In : Pathogens and Disease. 70, 3, p. 205-211 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  91. Published

    Effects of Radix Ginseng on microbial infections: a narrative review

    Wu, H., Høiby, Niels, Yang, L., Givskov, Michael & Song, Z., Apr 2014, In : Journal of Traditional Chinese Medicine. 34, 2, p. 227-233 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Pharmacokinetic variability of clarithromycin and differences in CYP3A4 activity in patients with cystic fibrosis

    Dalbøge, C. S., Nielsen, X. C., Dalhoff, K., Alffenaar, J. W., Duno, M., Buchard, Anders, Uges, D. R. A., Jensen, A. G., Jürgens, G., Pressler, T., Johansen, H. K. & Høiby, Niels, Mar 2014, In : Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 13, 2, p. 179-85 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    Bacterial biofilm formation and treatment in soft tissue fillers

    Alhede, M., Er, O., Eickhardt, S., Kragh, Kasper Nørskov, Alhede, M., Hultqvist, Louise Dahl, Poulsen, Steen Seier, Givskov, Michael, Christensen, L. H., Høiby, Niels, Tvede, M. & Bjarnsholt, Thomas, 30 Jan 2014, In : Pathogens and Disease. 70, p. 339-346 8 p.

    Research output: Contribution to journalJournal articleResearch

  94. Published

    Staphylococcus aureus alters growth activity, autolysis and antibiotic tolerance in a human host-adapted Pseudomonas aeruginosa lineage

    Michelsen, C. F., Christensen, A. J., Bojer, Martin Saxtorph, Høiby, Niels, Ingmer, Hanne & Jelsbak, L., 2014, In : Journal of Bacteriology. 196, 22, p. 3903-3911 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    Bactericidal effect of colistin on planktonic Pseudomonas aeruginosa is independent of hydroxyl radical formation

    Brochmann, R. P., Toft, A., Ciofu, Oana, Briales, A., Kolpen, M., Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Jensen, Peter Østrup, 2014, In : International Journal of Antimicrobial Agents. 43, 2, p. 140-147 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  96. Published

    Environmental Heterogeneity Drives Within-Host Diversification and Evolution of Pseudomonas aeruginosa

    Markussen, T., Marvig, R. L., Gómez-Lozano, M., Aanæs, K., Burleigh, A. E., Høiby, Niels, Johansen, Helle Krogh, Molin, S. & Jelsbak, L., 2014, In : mBio. 5, 5, p. 1-10 10 p., e01592-14.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin against Pseudomonas aeruginosa biofilms

    Jensen, Peter Østrup, Briales, A., Brochmann, R. P., Wang, H., Kragh, Kasper Nørskov, Kolpen, M., Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Ciofu, Oana, 2014, In : Pathogens and Disease. 70, 3, p. 440-443 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    Nitric oxide production by polymorphonuclear leukocytes in infected cystic fibrosis sputum consumes oxygen

    Kolpen, M., Bjarnsholt, Thomas, Moser, Claus Ernst, Hansen, C. R., Rickelt, L. F., Kühl, Michael, Hempel, C., Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2014, In : Clinical and Experimental Immunology. 177, 1, p. 310–319 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection

    Kolpen, M., Kühl, Michael, Bjarnsholt, Thomas, Moser, Claus Ernst, Hansen, C. R., Liengaard, L., Kharazmi, A., Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2014, In : PLOS ONE. 9, 1, p. e84353 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    PNA-based fluorescence in situ hybridization for identification of bacteria in clinical samples

    Fazli, Mustafa, Bjarnsholt, Thomas, Høiby, Niels, Givskov, Michael & Tolker-Nielsen, Tim, 2014, In : Methods in Molecular Biology. 1211, p. 261-71 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  101. Published

    Pharmacokinetics and pharmacodynamics of antibiotics in biofilm infections of Pseudomonas aeruginosa in vitro and in vivo

    Hengzhuang, W., Høiby, Niels & Ciofu, Oana, 2014, In : Methods in molecular biology (Clifton, N.J.). 1147, p. 239-54 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  102. Published

    Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum

    Line, L., Alhede, M., Kolpen, M., Kühl, Michael, Ciofu, Oana, Bjarnsholt, Thomas, Moser, Claus Ernst, Toyofuku, M., Nomura, N., Høiby, Niels & Jensen, Peter Østrup, 2014, In : Frontiers in Microbiology. 5, 11 p., 554.

    Research output: Contribution to journalJournal articleResearchpeer-review

  103. Published

    Polymorphonuclear leukocytes restrict growth of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients

    Kragh, Kasper Nørskov, Alhede, M., Jensen, Peter Østrup, Moser, Claus Ernst, Scheike, Thomas, Jacobsen, C. S., Poulsen, Steen Seier, Eickhardt-Sørensen, S. R., Trostrup, H., Christoffersen, L., Hougen, H. P., Rickelt, L. F., Kühl, Michael, Høiby, Niels & Bjarnsholt, Thomas, 2014, In : Infection and Immunity. 82, 11, p. 4477-4486 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  104. Published

    Rapid identification of Stenotrophomonas maltophilia by peptide nucleic acid fluorescence in situ hybridization

    Knudsen, N. R., Rasmussen, A. K. I., Fiandaca, M. J., Kragh, Kasper Nørskov, Bjarnsholt, Thomas, Høiby, Niels, Stender, H. & Guardabassi, Luca, 2014, In : New Microbes and New Infections. 2, 3, p. 79-81 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  105. Published

    Shifting paradigms of nontuberculous mycobacteria in cystic fibrosis

    Qvist, T., Pressler, T., Høiby, Niels & Katzenstein, T. L., 2014, In : Respiratory research. 15, p. 1-6 6 p., 41.

    Research output: Contribution to journalComment/debateResearch

  106. Published

    Sinus biofilms in patients with cystic fibrosis: is adjusted eradication therapy needed?

    Aanæs, Kasper, Eickhardt, S., Johansen, Helle Krogh, von Buchwald, Christian, Skov, M., Høiby, Niels & Bjarnsholt, Thomas, 2014, In : European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. p. 1-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  107. 2013
  108. Published

    Applying insights from biofilm biology to drug development - can a new approach be developed?

    Bjarnsholt, Thomas, Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Oct 2013, In : Nature Reviews. Drug Discovery. 12, 10, p. 791-808 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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