A complete analysis of the T cell epitopes induced by Yellow Fever virus vaccination


Project duration: February 2010 to December 2019 

The purpose of the experiment was to investigate how the body's immune system responds to the yellow fever vaccine. The purpose of any vaccine is to prepare the white blood cells of the immune system so they rapidly and efficiently can recognize and eradicate a particular invading microorganism (in this case, the yellow fever virus) if one should ever become infected.

However, we did not know much about which parts of the yellow fever virus were recognized by the white blood cells.
We have considerable expertise in modeling immune responses and discovering immune targets.Investigating the immune responses following yellow fever vaccination were a great opportunity to test this knowledge in an environment that is safe, yet closely mimics the situation during a real infection.