Inflammation & Immune regulation
Using the adoptive T cell transfer model of colitis we analyse the individual cellular and humoral components of the immune system as well as the interaction between the immune system and the enteric nerve system which initiate, sustain and eventually counter regulate the pathological changes leading to the chronic inflammatory pathology of IBD. In order to elucidate interactions between enteroantigen derived from the enteric microbiota and the adaptive immune system, we are currently characterizing the phenotype and function of B cells and their secreted antibodies with specificity for enteroantigens.
In collaboration with Amplimmune Inc.,USA, the immune regulatory potential of a recently developed B7H4-Ig fusion protein is studied in mouse and man. Potentially this protein might be useful in the treatment of various autoimmune diseases.